Article
Environmental Sciences
P. Senthil Kumar, G. Padmalaya, N. Elavarasan, B. S. Sreeja
Summary: GO-ZnO is a novel nanomaterial that has attracted researchers' attention. Its intriguing physical and electrochemical properties make it widely used in electrochemical sensor applications. Understanding the structural role of GO-ZnO and its modification process is crucial for maximizing its potential.
Article
Biochemical Research Methods
Taylor Battellino, Kosuke Ogata, Victor Spicer, Yasushi Ishihama, Oleg Krokhin
Summary: In this study, the sensitivity of peptide analysis and chromatographic behavior were compared between formic acid and acetic acid in reversed-phase liquid chromatography-tandem mass spectrometry (LC-MS/MS) applications. The results showed that acetic acid resulted in a 2.2-2.5 times increase in MS signal and a slight decrease in retention compared to formic acid. The number of identified peptides was up to 60% higher under acetic acid conditions, depending on the sample type. The retention shift was found to be dependent on peptide net charge and demonstrated the hydrophilicity of acetic acid.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Chemistry, Applied
Minxin Shi, Tianren Lu, Xiancai Li, Yifeng Yang
Summary: In this study, lanthanum ion-imprinted polymer La-IIP-MAA/Fe3O4-GO was prepared using ion-imprinting technology. The material showed good adsorption effects and selectivity for lanthanum ions, and maintained good performance after repeated use five times.
JOURNAL OF RARE EARTHS
(2022)
Article
Engineering, Electrical & Electronic
Sukhbir Singh, Jatinder Kumar Goswamy, Gaurav Sapra, Preetika Sharma
Summary: This work explores the use of graphene sheet as a sensing platform for detecting toxic gases in the environment. The study finds that oxides show better detection capability on the GO platform, while gas molecules containing methyl group chlorides also exhibit some detection ability.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Chemistry, Medicinal
Changxuan Shao, Qiao Jian, Bowen Li, Yongjie Zhu, Weikang Yu, Zhongyu Li, Anshan Shan
Summary: The development of membrane-soluble antimicrobial peptides (AMPs) is urgently needed to address the problem of drug-resistant bacterial infections. However, issues such as poor biocompatibility, salt sensitivity, and proteolytic lability hinder their clinical use. In this study, a series of ultrashort stapled cyclization heptapeptides were created by inserting all-hydrocarbon staples. The most promising peptide, stRRL, demonstrated exceptional antibacterial activity and stability in high-protease and high-salt environments, making it a potential candidate to replace antibiotics for tackling bacterial infections.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Electrical & Electronic
Xinru Li, Zhidong Lin, Liming Liu, Xiaowen Zhang
Summary: NaBi(MoO4)(2) mesoporous material was successfully synthesized using a solvothermal method, and composites doped with Co3O4 and CuO were prepared. The average grain size of the nanoparticles was approximately 31 nm, and they exhibited a mesoporous structure. Co3O4 was uniformly distributed on the surface of NaBi(MoO4)(2) nanoparticles to form heterojunctions. The Co3O4-doped composite showed superior gas-sensitive properties compared to the pure NaBi(MoO4)(2) mesoporous material.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
T. Sonia, D. Balamurugan, B. G. Jeyaprakash
Summary: Zinc Oxide (ZnO) was deposited on glass substrates by spray pyrolysis method at 350°C, showing higher response and selectivity to acetone vapor. The sensor exhibited faster response and recovery towards acetone at the same operating temperature, with good surface compositional stability after continuous exposure for 10 hours.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Chemistry, Physical
Huaqiang Fu, Zhe Wang, Peng Li, Wei Qian, Zixin Zhang, Xin Zhao, Hao Feng, Zhugen Yang, Zongkui Kou, Daping He
Summary: This study successfully improves water permeance and purification performance for efficient wastewater treatment by constructing well-structured three-dimensional water channels in GO/SiO2 composite membranes. The 3D channels achieve a record-high water permeance and demonstrate excellent charge selectivity towards dye molecules in wastewater.
Article
Chemistry, Physical
Huaqiang Fu, Zhe Wang, Peng Li, Wei Qian, Zixin Zhang, Xin Zhao, Hao Feng, Zhugen Yang, Zongkui Kou, Daping He
Summary: This study demonstrates the positive role of well-structured three-dimensional channels in improving water permeance and purification performance for highly efficient wastewater treatment using graphene oxide-based membranes. The regular and negatively-charged three-dimensional channels significantly enhance water permeance and enable effective dye rejection.
Article
Chemistry, Multidisciplinary
Tiantian Feng, Yihui Yuan, Shilei Zhao, Lijuan Feng, Bingjie Yan, Meng Cao, Jiacheng Zhang, Wenyan Sun, Ke Lin, Ning Wang
Summary: The detection of environmental uranyl is a topic of increasing interest. This study presents a detection strategy based on the unique uranyl-triggered photocleavage property, using fluorescent-molecule-labelled protein fragments to achieve high selectivity and a low detection limit of 24 pM for uranyl detection. The method shows high reliability and stability, making it promising for practical applications in diverse environments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Rita Borzsei, Balazs Zoltan Zsido, Monika Balint, Zsuzsanna Helyes, Erika Pinter, Csaba Hetenyi
Summary: This study produced structures of the somatostatin-SSTR4 complex using an unbiased docking approach and elucidated the binding mechanism of SST through explicit water molecular dynamics calculations, identifying key binding modes and residues for future drug design targeting SSTR4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Chenyu Zhang, Xiang Li, Zhenjian Xing, Honglan Zhong, Dianbao Yu, Rui Yu, Xin Deng
Summary: In this study, an anticancer AMP (Mastoparan) and its derivatives were designed and evaluated. Preliminary studies showed that the Mastoparan analogue KM8 exhibited selective antitumor effects but had metabolic instability. By substituting the 9Ala residue in KM8, a long-acting derivative KM8-Aib was generated, which showed higher metabolic stability, potent anticancer activity, and lower toxicity. Therefore, KM8-Aib is suggested as a potential antimalignant agent for further study.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Hanqing Wu, Huiling Chen, Sining Zheng, Hongyu Guo, Fafu Yang
Summary: A new fluorescent sensor TBTPI was reported for the selective and sensitive detection of pesticide starane, showing great potential for agricultural and daily life applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Li Du, Chunli Song, Jingjing Du, Fang Zeng, Yu Zhang, Feng Yin, Zigang Li, Dongyuan Wang
Summary: The anti-cancer peptides show potential as new weapons for cancer therapy with potent toxicity against various cancer cells, but their promise is hindered by non-specific toxicity to normal cells. This study designed a sul-fonium tethered lytic peptide conjugated with a HDAC inhibitor to improve the selectivity towards cancer cells. The peptide showed reduced toxicity to both cancer cells and normal cells, and when conjugated with the HDAC inhibitor, it exhibited increased toxicity to cancer cells. The stabilized peptide HDAC conjugate also showed better serum stability and could induce cancer cell apoptosis, cell cycle arrest, and influence multiple signal pathways.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Anjitha Thadathil, Dipin Thacharakkal, Yahya A. Ismail, Pradeepan Periyat
Summary: Sensitive monitoring of dopamine levels is crucial for healthcare. Nitrogen-doped graphene quantum dots (N-GQDs) synthesized in this study act as efficient electrochemical catalysts for dopamine detection. These sensors exhibit superior selectivity and sensitivity, making them promising for medical diagnostic applications.
Article
Chemistry, Analytical
Weijie Chen, Chen Zhang, Huijuan Chen, Kun Zang, Sheng Hua Liu, Yuan Xie, Ying Tan, Jun Yin
Summary: In this study, a thienoisoindigo fluorophore was utilized to construct near-infrared fluorescent materials with aggregation-induced emission, showing excellent photostability and lysosomal targeting capability for in vivo fluorescence imaging.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Lei Zhao, Tingting Fan, Zhichao Shi, Chao Ding, Cunlong Zhang, Zigao Yuan, Qinsheng Sun, Chunyan Tan, Bizhu Chu, Yuyang Jiang
Summary: The novel series of multitargeted inhibitors showed moderate activity in EGFR-resistant lung cancer cells, providing insights into the molecular mechanisms of both EGFR wild-type and EGFR(T790M) resistance mutation, with low toxicity towards normal cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Bifei Li, Jianhui Li, Wei Gan, Ying Tan, Qunhui Yuan
Summary: This study utilized SHG and TPF spectra to investigate the dynamics of an amphiphilic ion D289 on K562 cells, revealing its adsorption and cross-membrane transport within the cells and organelles. SHG images demonstrated the capability of probing molecular dynamics in organelles in K562 cells, showing the first investigation of cross-membrane transport dynamics on subcellular organelles' surfaces.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yuyao Jin, Nan Du, Yuanfang Huang, Wanxiang Shen, Ying Tan, Yu Zong Chen, Wei-Tao Dou, Xiao-Peng He, Zijian Yang, Naihan Xu, Chunyan Tan
Summary: Emerging liquid biopsy methods, such as the breast cancer liquid biopsy system developed in this study, provide a promising noninvasive approach for detecting and classifying cancer cells based on fluorescence signals collected from cells and exosomes. The integration of a fluorescence sensor array and deep learning tool AggMapNet allows for accurate differentiation between normal and cancerous cells, as well as accurate prediction of breast cancer in plasma-derived exosomes.
Article
Chemistry, Multidisciplinary
Bao-Cheng Wang, Tingting Fan, Fen-Ya Xiong, Peng Chen, Kai-Xin Fang, Ying Tan, Liang-Qiu Lu, Wen-Jing Xiao
Summary: This study reports a Cu-catalyzed asymmetric cyclization reaction for the efficient synthesis of chiral 3-aminoindolines with high yield and enantioselectivity. The resulting products can undergo a radical-mediated sulfonyl migration to generate chiral 3-aminoindolines with alkenyl sulfonyl groups. Bioactivity evaluations demonstrate that these chiral 3-aminoindolines show notable antitumor activities and the chirality of the compounds plays a significant role in their antitumor activity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Hui Chen, Zhiyuan Zhuang, Yan Chen, Cheng Qiu, Ying Qin, Chunyan Tan, Ying Tan, Yuyang Jiang
Summary: A new platform based on branched rolling circle amplification and CRISPR-Cas12a was developed for the detection of multiple circulating non-coding RNAs as biomarkers for early-stage colorectal cancer diagnosis. The method showed high detection sensitivity and consistent results with the conventional RT-qPCR method. This one-pot, isothermal, and specific BRCACas platform holds promise as a rapid, adaptable, and practical diagnostic/prognostic cancer screening method.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Medicinal
Tianyi Wang, Ying Tan, Yu Zong Chen, Chunyan Tan
Summary: Infrared (IR) spectroscopy is a powerful tool for analyzing functional groups in organic compounds. This paper presents a new deep learning method for transforming IR spectral features into intuitive image-like feature maps and predicting major functional groups. The method successfully identifies 21 major functional groups for each molecule without expert guidance and feature selection, and it also shows potential for automated analysis in various fields.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Nanoscience & Nanotechnology
Weijie Chen, Huijuan Chen, Yurou Huang, Ying Tan, Chunyan Tan, Yuan Xie, Jun Yin
Summary: Organic fluorescent dyes with aggregation-induced emission (AIE) property have extensive applications in imaging, labeling, and adjusting microprocesses in aggregated environments. Thienoisoindigo derivatives with AIE characteristics, such as TII-TPE, have been developed and demonstrated high photostability and efficient photothermal conversion efficiency. These derivatives can be used as functional AIE structures by installing AIE blocks or other rotatable groups. The nanoparticles prepared from thienoisoindigo and tetraphenylethene (TII-TPE) and thienoisoindigo and triphenylamine (TII-TPA) showed significant inhibitory effects on tumor growth in a tumor mouse model after four treatment cycles.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Weijie Chen, Huijuan Chen, Yurou Huang, Ying Tan, Chunyan Tan, Yuan Xie, Jun Yin
Summary: Organic fluorescent dyes with aggregation-induced emission (AIE) property have a wide range of applications in imaging, labeling, and microprocesses in aggregated environments. In this study, a thienoisoindigo derivative with AIE characteristics was developed and nanoparticles were prepared, showing significant inhibition of tumor growth.
ACS APPLIED BIO MATERIALS
(2022)
Article
Food Science & Technology
Xin Yu Zhao, Nan Du, Yuanfang Huang, Yishun Shen, Ying Tan, Chunyan Tan
Summary: An array of three fluorescent sensors has been developed for the discrimination of powdered infant formulas by species, country of origin, and brand, showing comparable or superior speed and efficacy to existing methods without the need for sample pre/post-treatment.
ACS FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Junyue Chen, Tian Jin, Jingfeng Li, Xinyan Zhang, Feng Liu, Chunyan Tan, Ying Tan
Summary: A biosensor based on cationic polymers and nuclease-assisted cyclic amplification has been developed for the high sensitivity and specificity detection of multiple DNA and microRNA in a one-pot reaction. The biosensor utilizes a novel polymer quencher and DNA probes modified with multiple fluorophores to achieve specific and accurate detection even for single-base mismatches. This system shows promising potential for clinical diagnostics by distinguishing miRNA expression in various cell lines with reliable performance in real biological samples.
ACS APPLIED BIO MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Jiatong Li, Nan Du, Ying Tan, Hsien-Yi Hsu, Chunyan Tan, Yuyang Jiang
Summary: Metal coordination-driven composite systems with excellent stability and pH-responsive ability show potential for specific drug delivery in physiological conditions. pH-responsive nanoparticles, PPEIDA-Cu-DOX CPNs, constructed in this study exhibit high drug loading, efficient drug release monitoring, and lower toxicity to normal cells, demonstrating feasibility for cancer treatment.
ACS APPLIED BIO MATERIALS
(2021)
Article
Computer Science, Artificial Intelligence
Wan Xiang Shen, Xian Zeng, Feng Zhu, Ya Li Wang, Chu Qin, Ying Tan, Yu Yang Jiang, Yu Zong Chen
Summary: The study demonstrates that combining human knowledge-based molecular representations with convolutional neural networks can enhance deep learning of pharmaceutical properties. By extensively learning molecular descriptors and fingerprint features, the MolMap method was developed and MolMapNet models were constructed, which outperformed other models on various benchmark datasets and a novel dataset.
NATURE MACHINE INTELLIGENCE
(2021)
