期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 40, 期 4, 页码 331-341出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-018-0685-x
关键词
ILC; NK cells; NCR; Checkpoints
资金
- European Research Council advanced grant (TILC.)
- Agence Nationale de la Recherche
- Equipe Labellisee ''La Ligue,'' Ligue Nationale contre le Cancer
Innate lymphoid cells (ILCs) are innate immune cells located in lymphoid and non-lymphoid tissues. They are particularly abundant at mucosal and barrier surfaces. Three major ILC subsets are present in humans and mice: group 1 ILCs (comprising natural killer (NK) cells and ILC1s), ILC2s, and ILC3s. ILCs are involved in the maintenance of homeostasis and the regulation of immunity. This review focuses on the extensive array of activating and inhibitory receptors expressed by ILCs for communication with other cell types and their environment in health and disease.
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