Review
Biochemistry & Molecular Biology
Sandra Winning, Joachim Fandrey
Summary: Oxygen deprivation is a common feature at inflamed sites, and immune cells adapt to this condition by activating HIF. HIF plays a significant role in regulating the inflammatory phenotype of immune cells, including migration, phagocytosis, and induction of inflammatory cytokines. However, further research is needed to understand the specific roles of HIF-1 and HIF-2 in different cell types.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Immunology
Jianya Peng, Hannah G. G. Federman, Christina M. Hernandez, Mark C. C. Siracusa
Summary: Parasitic helminth infections are a global health issue, causing significant morbidity and economic hardships. Host protective responses to helminths involve the initiation of type 2 inflammation and the involvement of various immune cells. Recent studies have also highlighted the importance of neuro-immune interactions in regulating anti-helminth immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Xiaodong Zhang, Xiaokai Chen, Yanli Zhao
Summary: Artificial nanosystems have the ability to modulate immune responses and can be used in vaccine development and treatment of bacterial infections and diseases. This review discusses the recent advances of nanosystems in vaccine development and immune activation, as well as the application of immune-suppressive nanosystems.
ACS APPLIED NANO MATERIALS
(2022)
Article
Immunology
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Summary: This study provides insight into epigenetic profiles and transcription factor networks associated with transcriptional signatures of tolerized and trained microglia in vivo, leading to a better understanding of innate immune memory of microglia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Pharmacology & Pharmacy
Ali Attiq, Sheryar Afzal
Summary: Unresolved inflammation caused by persistent inflammatory stimulus and regulatory perturbation increases the risk of tumor development and plays a key role in tumorigenesis. In some cancers, inflammatory processes create a favorable environment for neoplastic transformation, while in others, oncogenic changes lead to an inflammatory microenvironment that promotes tumor development. The complex network of stromal and immune cells in the tumor microenvironment contributes to cancer-promoting inflammation and smoldering inflammation in various tumor types. Understanding the molecular mechanisms and pathways connecting inflammation and tumor development is crucial for developing targeted cancer therapies.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Mingyue Gao, Dawei Cui, Jue Xie
Summary: As an essential regulator of the immune system, adiponectin plays a crucial role in regulating the function of innate and adaptive immune cells in the development of obesity and its related diseases. It also has positive effects on systemic metabolism by regulating associated downstream signalling pathways. This review highlights the biological function of adiponectin in regulating innate and adaptive immunity and its key role in various metabolic diseases, providing a potential direction for adiponectin-based therapeutic interventions.
DIABETES OBESITY & METABOLISM
(2023)
Review
Immunology
Daniel Sijmons, Andrew J. Guy, Anna K. Walduck, Paul A. Ramsland
Summary: This review discusses the importance of Helicobacter pylori infection and its impact on the host immune system, including mechanisms such as modulation of cell function, secretion of immune signaling molecules, and interference with immune cell differentiation. H. pylori also utilizes its unique lipopolysaccharide structure to mimic the host and interacts with the host through outer membrane proteins.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Elsa Anes, David Pires, Manoj Mandal, Jose Miguel Azevedo-Pereira
Summary: This review highlights the spatial localization of cathepsins and their implications in immune activation and resolution pathways during infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Ronan Talty, Kelly Olino
Summary: Both cancer cells and immune cells rely on specific metabolic programs for survival and function, with immune cells having the capability to either enhance or suppress the antitumor immune response based on metabolic changes. The shared microenvironment within tumors affects the metabolism of immune cells and can impact the efficacy of immunotherapies, highlighting the importance of understanding the interplay between metabolism, immune response, and cancer progression.
Review
Immunology
Wen Cao, Dongsheng Fan
Summary: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease characterized by motor neuron loss. Dysregulated peripheral immunity, particularly the role of neutrophils, has been implicated in ALS pathogenesis. Understanding the functions of neutrophils in ALS and their potential as therapeutic targets could provide insights into slowing disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Erica M. Orsini, Apostolos Perelas, Brian D. Southern, Lisa M. Grove, Mitchell A. Olman, Rachel G. Scheraga
Summary: Innate immune cells are able to sense and respond to their physical environment through mechanical signals transmitted via mechanosensitive ion channels and cell adhesion molecules, which then activate intracellular signaling pathways to regulate gene expression and cellular function. Understanding how immune cells interpret mechanical information may provide potential targets for treating human diseases. Areas of future studies include autoimmune, allergic, infectious, and malignant conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Michael S. McGrath, Rongzhen Zhang, Paige M. Bracci, Ari Azhir, Bruce D. Forrest
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes voluntary muscle function loss and often leads to death within 2-5 years. Respiratory vital capacity (VC) measurements can predict survival, and a study has found a potential therapeutic approach for controlling VC loss in ALS patients by regulating the innate immune system. Patients with high levels of plasma CRP showed a slower decline in VC compared to placebo, while those with low CRP showed no response. This study provides the first evidence linking biomarker-confirmed regulation of the innate immune system with a potential treatment for VC loss in ALS patients.
Review
Biochemistry & Molecular Biology
Haina Zhang, Yeling Wang, Hongbo Men, Wenqian Zhou, Shanshan Zhou, Quan Liu, Lu Cai
Summary: CARD9 is a crucial adaptor protein involved in the pathogenesis of cardiovascular diseases, including inflammation, apoptosis, and autophagy. By regulating signaling pathways and cytokine production, CARD9 plays a significant role in the development of CVDs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Apple Cortez Vollmers, Sergio Covarrubias, Daisy Kuang, Aaron Shulkin, Justin Iwuagwu, Sol Katzman, Ran Song, Kasthuribai Viswanathan, Christopher Vollmers, Edward Wakeland, Susan Carpenter
Summary: Recent studies have identified a previously unknown function for the lncRNA GAPLINC, which acts as a negative regulator of inflammation in the context of innate immunity, macrophages, and LPS-induced endotoxic shock. Transcriptome analysis in human and mouse macrophages showed that GAPLINC is highly expressed following macrophage differentiation, but rapidly down-regulated upon inflammatory activation. Depletion of GAPLINC leads to enhanced expression of inflammatory genes, while overexpression suppresses this response, ultimately modulating endotoxic shock and multiorgan failure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)