期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 80, 期 -, 页码 29-34出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.11.007
关键词
PML nuclear bodies; Sumoylation; P53; Oxidative stress; NRF2
资金
- Institut National du Cancer
- Association pour la Recherche contre le Cancer
- European Research Council [268729-STEMAPL]
- INCA
- French National Research Agency (ANR) Investissements d'Avenir program [ANR-11-PHUC-002, ANR-10-IHUB-0002, ANR-13-JSV2-0005-01]
PML Nuclear bodies (PML NBs) are spherical domains associated with a broad range of activities upon stress responses such as apoptosis, senescence DNA repair, epigenetic control, as well as control of oncogenesis. These bodies are considered as privileged sites for post-translational modifications, where sumoylation plays a key role. Here we summarize recent in vitro and in vivo findings on the link between PML NBs and ROS, in particular PML contributions to oxidative stress response. We discuss how it may regulate switch from cell protection against stress to cell arrest/cell death. (C) 2017 Elsevier Ltd. All rights reserved.
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