期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 86, 期 -, 页码 24-35出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2018.02.014
关键词
Plasmacytoid dendritic cells; Innate sensing; Adaptive immunity; Type I Interferon; Human diseases
Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both T cell activation or tolerance. In this review, we described pDC functions during immune responses and their implication in the clearance or pathogenicity of human diseases during infection, autoimmunity, allergy and cancer. We discuss recent advances in the field of pDC biology and their implication for future studies. (C) 2018 Elsevier Ltd. All rights reserved.
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