期刊
SEMINARS IN CANCER BIOLOGY
卷 50, 期 -, 页码 124-131出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2017.09.009
关键词
Forkhead box 01; Digestive malignancy; Hepatocellular carcinoma; Akt; microRNA
类别
资金
- International Cooperation Program of Shaanxi Province, China [2016KW-004]
- Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University, China [XJTU1AF-CRF-2015-029]
- NIH [R01DK100342, R01DK113144, R01HL132996]
Digestive malignancies are the leading cause of mortality among all neoplasms, contributing to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung cancer and prostate cancer in recent years. The transcription factor Forkhead Box O1 (FOXO1) is a key member of Forkhead Box family, regulating diverse cellular functions during tumor initiation, progression and metastasis. In this review, we focus on recent studies investigating the antineoplastic role of FOXO1 in digestive malignancy. This review aims to serve as a guide for further research and implicate FOXO1 as a potent therapeutic target in digestive malignancy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据