K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair

Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis

(2016) Christine M. Kondratick et al.   PLoS One

Akt-Mediated Phosphorylation of XLF Impairs Non-Homologous End-Joining DNA Repair

(2015) Pengda Liu et al.   MOLECULAR CELL

K29-Selective Ubiquitin Binding Domain Reveals Structural Basis of Specificity and Heterotypic Nature of K29 Polyubiquitin

(2015) Yosua Adi Kristariyanto et al.   MOLECULAR CELL

Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin

(2015) Martin A. Michel et al.   MOLECULAR CELL

Protein neddylation: beyond cullin–RING ligases

(2015) Radoslav I. Enchev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction

(2014) Lixin Wan et al.   DEVELOPMENTAL CELL

DNA repair diseases: what do they tell us about cancer and aging?

(2014) Carlos FM Menck et al.   GENETICS AND MOLECULAR BIOLOGY

Poly(ADP-ribose): An organizer of cellular architecture

(2014) Anthony K.L. Leung   JOURNAL OF CELL BIOLOGY

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

(2014) Pengda Liu et al.   NATURE

Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair

(2014) Yu Zhao et al.   TRENDS IN CELL BIOLOGY

PTEN-Deficient Tumors Depend on AKT2 for Maintenance and Survival

(2014) Y. R. Chin et al.   Cancer Discovery

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

(2013) Siqi Liu et al.   eLife

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Acetylation-Dependent Regulation of Skp2 Function

(2012) Hiroyuki Inuzuka et al.   CELL

NMR analysis of Lys63-linked polyubiquitin recognition by the tandem ubiquitin-interacting motifs of Rap80

(2012) Naotaka Sekiyama et al.   JOURNAL OF BIOMOLECULAR NMR

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

(2012) Yogesh Kulathu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Roles of sequential ubiquitination of PCNA in DNA-damage tolerance

(2011) Weiwei Zhang et al.   FEBS LETTERS

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

(2010) Anja Bremm et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes

(2010) F Al-Ejeh et al.   ONCOGENE

Structural Transformation of the Tandem Ubiquitin-Interacting Motifs in Ataxin-3 and Their Cooperative Interactions with Ubiquitin Chains

(2010) Ai-Xin Song et al.   PLoS One

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80

(2009) Yusuke Sato et al.   EMBO JOURNAL

The ubiquitin landscape at DNA double-strand breaks

(2009) Troy E. Messick et al.   JOURNAL OF CELL BIOLOGY

A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1β

(2009) Ming Xu et al.   MOLECULAR CELL

Structure of the S5a:K48-Linked Diubiquitin Complex and Its Interactions with Rpn13

(2009) Naixia Zhang et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

(2009) Daming Gao et al.   NATURE CELL BIOLOGY

Ubiquitin-binding domains — from structures to functions

(2009) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architecture

(2009) Stephen D. Weeks et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

DeTEKting Ubiquitination of APC/C Substrates

(2008) Arthur L. Haas et al.   CELL

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

Crystallographic Analysis of a Sex-Specific Enhancer Element: Sequence-Dependent DNA Structure, Hydration, and Dynamics

(2008) Narendra Narayana et al.   JOURNAL OF MOLECULAR BIOLOGY