Article
Nanoscience & Nanotechnology
Meng Zhao, Xupeng Yang, Hao Fu, Chuanrong Chen, Yanhua Zhang, Zhihua Wu, Yourong Duan, Ying Sun
Summary: A novel tumor-targeted nanosized ultrasound contrast nanobubble was developed for more efficient molecular targeted therapy against triple-negative breast cancer (TNBC), showing potential in enhancing treatment efficacy and immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Qian An, Shengze Su, Wei Hu, Yanying Wang, Tao Liang, Xianghong Li, Chunya Li
Summary: Combining photothermal therapy (PTT) with photodynamic therapy (PDT) and other therapeutic tools can significantly enhance tumor-killing ability. Copper sulfide nanoparticle (CuS NP) photothermal reagents, when combined with PDT photosensitizers, can effectively construct a PTT/PDT combination therapeutic platform. The CuS@COF nanosheets prepared with a dual-ligand assistant strategy exhibit excellent photothermal conversion performance, high singlet oxygen yield, and high photothermal conversion efficiency.
Article
Chemistry, Physical
Jianxiu Lu, Wenjuan Wang, Ze Xu, Peiying Zhang, Jiake Gu, Zhilong Xu, Juqun Xi, Lei Fan
Summary: An injectable sodium alginate (SA)-based hydrogel embedded with CaCO3/polydopamine nanoparticles (CaCO3/PDA NPs) was developed for the synergistic photothermal/calcium ions interference therapy of melanoma. The fluid was converted into a hydrogel in situ, increasing the retention time of photothermal agents at tumor sites and promoting hyperthermia. The residual CaCO3/PDA NPs continuously released Ca2+ in the acidic tumor microenvironment, leading to mitochondrial Ca2+-overloading and cell death. This pH/NIR-responsive and injectable SA-based hydrogel showed enhanced treatment efficacy of melanoma through the synergism of photothermal therapy and calcium ions interference therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Qinghe Wu, You Zhang, Guoping Jia, Mengfei Hou, Yifei Jiang, Weijun Wei, Ping Liu, Gang Huang, Jianhua Zou, Jingjing Zhang, Wangxi Hai, Min Zhang, Biao Li, Xiaoyuan Chen, Chunfu Zhang
Summary: This study proposes a dual-locked strategy for safe and effective Cerenkov radiation-induced therapy (CRIT), using pH-activatable photosensitizers. The strategy shows promising results in tumor models, highlighting the potential of pH-activatable photosensitizers in cancer therapy.
Article
Chemistry, Applied
Shankun Yao, Yuncong Chen, Hongxia Xu, Fen Qi, Yuming Zhang, Tao Yang, Yanping Wu, Hongbao Fang, Weijiang He, Zijian Guo
Summary: Multimodal imaging-guided phototherapy using a hypoxia-activated near infrared probe has been developed for tumor elimination. The probe can release a fluorescence group under hypoxia, leading to enhanced NIR fluorescence signal. Additionally, the released group can generate singlet oxygen and exhibit photothermal effects. In vivo studies demonstrated selective enhancement of fluorescence and photoacoustic signals in the tumor region. Furthermore, the synergistic effect of photodynamic therapy and photothermal therapy significantly suppressed tumor growth.
Article
Nanoscience & Nanotechnology
Shaojing Zhao, Ke Yang, Lirong Jiang, Jiafu Xiao, Benhua Wang, Lintao Zeng, Xiangzhi Song, Minhuan Lan
Summary: This study developed red fluorescent N,S-doped carbon dots as a potential effective photosensitizer for imaging-guided PDT, with the ability to generate singlet oxygen and accumulate in lysosomes and mitochondria in tumor cells. These carbon dots exhibit excellent biocompatibility, chemostability, and a large Stokes shift, making them promising for cancer therapy.
ACS APPLIED NANO MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Sooho Yeo, Il Yoon, Woo Kyoung Lee
Summary: In this study, a photosensitizer (methyl pheophorbide a, MPa) was synthesized and a biocompatible lipid-based nanocarrier was designed to enhance its bioavailability and pharmacological effects in photodynamic therapy (PDT). The nano-transfersomes loaded with MPa exhibited sustained drug release, pH-responsive drug release, enhanced photodynamic activity, and reduced side effects, making them a promising anti-cancer strategy for PDT.
Article
Nanoscience & Nanotechnology
Xiaolu Chen, Ping Song, Wanzhen Li, Jun Wang, Ting Gui, Weiwei Zhang, Fei Ge, Longbao Zhu
Summary: Photodynamic therapy (PDT) is an efficient strategy for tumor treatment, but insufficient oxygen and hydrogen peroxide (H2O2) in the tumor microenvironment limit its effectiveness. This study designed a pH-responsive H2O2 and O-2 self-supplying hybrid nanoparticle, which could release oxygen (O-2) to alleviate hypoxia and enhance PDT in the acidic tumor microenvironment. The nanocomposite effectively delivered chemotherapeutic drug doxorubicin (DOX) and photosensitizer 5,10,15,20-tetrakis(4-aminophenyl) porphyrin (TAPP) to the tumor site and demonstrated efficient inhibition of tumor growth both in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Koushik Bhattacharya, Subhayan Das, Moumita Kundu, Sudarshan Singh, Uddhab Kalita, Mahitosh Mandal, Nikhil K. Singha
Summary: This study demonstrates the synthesis of a block copolymer containing water-soluble photosensitizer and anticancer drug. When anchored on gold nanoparticles, the hybrid system exhibits triggered drug release and reactive oxygen species generation, showing promising cytotoxic effects on breast cancer cells.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Analytical
Xiao Liu, Xiangyang Gong, Jie Yuan, Xiaopeng Fan, Xingxing Zhang, Tianbing Ren, Sheng Yang, Ronghua Yang, Lin Yuan, Xiao-Bing Zhang
Summary: A new dual-stimulus responsive near-infrared reversible ATP-pH probe has been developed for fluorescence and photoacoustic ratiometric imaging of tumors, effectively reducing cumulative response after intravenous injection and suitable for in vivo imaging.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Yi Feng, Xiaoxue Xie, Hanxi Zhang, Qingqing Su, Geng Yang, Xiaodan Wei, Ningxi Li, Tingting Li, Xiang Qin, Shun Li, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Guixue Wang, Hong Yang, Yiyao Liu
Summary: This study developed a tumor microenvironment-responsive nanocarrier for on-demand release of therapeutic agents and a photosensitizer, achieving enhanced tumor penetration and uptake through enzyme and redox reactions. By blocking immune checkpoints and enhancing antitumor immune responses, the platform significantly improves therapeutic outcomes.
Article
Engineering, Biomedical
Man Shu, Junjie Tang, Lili Chen, Qiang Zeng, Chao Li, Shuting Xiao, Zhaozhong Jiang, Jie Liu
Summary: A novel combined chemo/photodynamic therapy has been developed using pH/ROS/MMP-2 triple-responsive drug nanocarriers for efficient treatment of solid tumors. The nanoparticles can effectively accumulate in tumors, release drugs in response to intracellular pH and ROS levels, and amplify ROS generation with external laser irradiation to achieve extraordinary therapeutic efficacy. The treatment showed substantial tumor shrinkage and eradication with low toxicity in major organs, indicating great potential for tumor therapy.
Article
Biotechnology & Applied Microbiology
Jialin Fu, Choe Peng Leo, Pau Loke Show
Summary: This review compares the synthesis routes and applications of pH-responsive CaCO3-based drug delivery systems, non-drug delivery systems, imaging techniques, sensors, and templates. Various methods have been developed to build pH-responsive solutions using biocompatible calcium carbonate (CaCO3). The review identifies the novelty, limitations, and potential applications of each synthesis and application. The use of CaCO3 in drug delivery systems shows great potential for cancer treatment, with impregnation and encapsulation being widely used. In addition, CaCO3 has been utilized in ultrasound imaging, sensors, and sacrificial templates, showcasing its versatility.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Jie Xing, Qiuyu Gong, Ruifen Zou, Junlie Yao, Lingchao Xiang, Aiguo Wu
Summary: Despite the rapid development of fluorescence detection modalities for disease diagnosis, there is still immense pressure for novel fluorescent molecules and probes to transform before their clinic application. Remarkably, fluorescent probes based on traditional fluorescent dyes are expected to expedite this transformation process. In this study, methylene blue is utilized to intricately design the GSH responsive probe MB-SS-CPT. The synthesized MB-SS-CPT provides significant optical advantages for GSH detection in vitro, cell fluorescence imaging, in vivo imaging, and antitumor therapy.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Hao Hu, Hua Wang, Yuchong Yang, Jiang-Fei Xu, Xi Zhang
Summary: In this study, a cationic porphyrin derivative TMPyP was developed that could be used for specific bacteria-responsive antimicrobial treatment through adaptable photodynamic/photothermal therapy processes. The results showed that TMPyP exhibited strong antimicrobial activity (>99%) through photothermal therapy in hypoxic environments where facultative anaerobes with a strong reducing ability, such as E. coli and S. typhimurium, could reduce TMPyP to phlorin. In aerobic environments with aerobic bacteria, TMPyP functioned as a typical photosensitizer that effectively killed bacteria (>99.9%) through photodynamic therapy. The biocompatibility of TMPyP was significantly improved by forming a host-guest complex with cucurbit[7]uril. This bacteria-responsive porphyrin demonstrates specificity and adaptability in antimicrobial treatment and holds potential in non-invasive treatments of bacterial infections.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
