Article
Gastroenterology & Hepatology
Gangarao Davuluri, Nicole Welch, Jinendiran Sekar, Mahesha Gangadhariah, Khaled Alsabbagh Alchirazi, Maradumane L. Mohan, Avinash Kumar, Sashi Kant, Samjhana Thapaliya, McKenzie Stine, Megan R. McMullen, Rebecca L. McCullough, George R. Stark, Laura E. Nagy, Sathyamangla V. Naga Prasad, Srinivasan Dasarathy
Summary: Despite the high clinical significance of sarcopenia in alcohol-associated cirrhosis, the mechanisms of ethanol-induced impaired protein homeostasis are poorly understood. This study identified PP2A as a key mediator in ethanol-induced dysregulation of protein balance, suggesting potential therapeutic approaches targeting the PI3K gamma-PP2A axis.
Article
Cardiac & Cardiovascular Systems
Qun Wei, Hui Ren, Jun Zhang, Wen Yao, Baoxiang Zhao, Junying Miao
Summary: HCP1 inhibited oxLDL-induced VEC injury and promoted the stabilization of atherosclerotic plaque in apoE(-/-) mice, suggesting that it may be a potential therapeutic target for the treatment of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Rachel Aruldas, Laura Buczek Orenstein, Sade Spencer
Summary: Repeated cocaine exposure induces changes in AMPK and pAMPK in different brain regions and cellular compartments, with some differences between acute withdrawal and ongoing cocaine treatment. Pretreatment with metformin, an indirect AMPK activator, enhances acute cocaine-induced locomotor activity but blocks the development of sensitization. These findings provide insights into the dynamics of AMPK activation in subcellular compartments and support the potential use of metformin for the treatment of cocaine use disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Qing-xiang Zhao, Yi-hao Wang, Si-cong Wang, Song Xue, Zhen-xin Cao, Tao Sun
Summary: This study found that PDX can affect autophagy flux via AMPK signaling in LRP patients, showing pro-resolving properties and powerful analgesic effects.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yifei Chen, Fangpu Yu, Yu Zhang, Mengmeng Li, Mingxue Di, Weijia Chen, Xiaolin Liu, Yun Zhang, Mei Zhang
Summary: Tongxinluo (TXL) is a traditional Chinese medication that plays a key role in the formation and progression of atherosclerotic plaques by inhibiting lipid deposition through enhancing autophagy in macrophages. It also reverses the inhibitory effect of class I histone deacetylases on the expression of Beclin-1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Huijie Chen, Yue Zhang, Xue Qi, Xu Shi, Xiaodan Huang, Shi-Wen Xu
Summary: This study described the exacerbating effect of low selenium diet on autophagy in chicken kidney treated with bisphenol A (BPA), and elucidated the involvement of nitric oxide (NO) and AMPK/mTOR signaling pathways. These findings will enhance our understanding of the nephrotoxicity of BPA and the detoxification effect of selenium in chickens.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Janki M. Desai, Aniruddha S. Karve, Gary A. Gudelsky, Mruniya Gawali, William Seibel, Larry Sallans, Biplab DasGupta, Pankaj B. Desai
Summary: This study characterized the pharmacokinetics and metabolism of a potential drug, SBI-0206965, for the treatment of glioblastoma. The results showed that SBI-0206965 has adequate brain permeability but low oral bioavailability, possibly due to rapid hepatic metabolism. These findings will facilitate the further development of SBI-0206965 or other related compounds for the treatment of glioblastoma and other brain tumors.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Urology & Nephrology
Weiwei Shen, Nan Jia, Jinhua Miao, Shuangqin Chen, Shan Zhou, Ping Meng, Xuefeng Zhou, Lan Tang, Lili Zhou
Summary: Penicilliumin B has shown protective effects against cisplatin-induced renal tubular cell apoptosis by enhancing autophagic flux and promoting the activation of multiple autophagy-related proteins. Additionally, Penicilliumin B triggered AMPK phosphorylation, indicating its potential as an AMPK activator for protection against kidney injury.
Article
Chemistry, Applied
Takayoshi Tajima, Hiroaki Hoshii, Yoshinori Kohmura
Summary: This paper describes the research and development of a practical and efficient process for making the AMPK activator ASP4132, which includes efficient telescoping processes and effective removal of byproducts, resulting in a significant yield improvement.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Oncology
Jia Hao, Zhen Yang, Jian Li, Lifeng Han, Yi Zhang, Tao Wang
Summary: This study aimed to discover natural AMPK activators through virtual screenings, resulting in the identification of (-)-catechin and licochalcone A as the most potent compounds for AMPK activation.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Tongtong Shen, Yu Liu, Shuangshuang Dong, Xiaohong Xu, Xinxin Wang, Yong Li, Limin Zhou
Summary: The study shows that Alarin can alleviate myocardial hypertrophy by inhibiting the cAMP/PKA signaling pathway to attenuate autophagy, thus improving cardiac condition.
Article
Biochemistry & Molecular Biology
Yang Chen, Qian Li, Sisi Ren, Ting Chen, Bingtao Zhai, Jiangxue Cheng, Xiaoyan Shi, Liang Song, Yu Fan, Dongyan Guo
Summary: Curcuinin can treat hepatocellular carcinoma (HCC) through the p53 apoptotic pathway and the AMPK/Unc-51-like kinase 1 (ULK1) autophagy pathway, in which the mutual transformation of autophagy and apoptosis may occur through DRAM and p62.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Review
Medical Laboratory Technology
Kai Hou, Shuai Li, Meng Zhang, Xuping Qin
Summary: Caveolin-1 is a significant pathophysiological factor in atherosclerosis, potentially influencing autophagy activation. Understanding the exact mechanisms and roles of caveolin-1 in autophagic flux can lead to novel therapeutic approaches for atherosclerosis.
CLINICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Chunyang Du, Yan Zhu, Yan Yang, Lin Mu, Xue Yan, Ming Wu, Chenming Zhou, Haijiang Wu, Wei Zhang, Yanhui Wu, Guoyu Zhang, Yue Hu, Yunzhuo Ren, Yonghong Shi
Summary: CTRP3 plays a role in lipid metabolism and necroinflammation in renal tubular cells by inhibiting SREBP-1 expression, increasing PPAR-α and ABCA1 expression, and inhibiting NLRP3-mediated inflammation and MLKL-dependent necroinflammation. It also activates the AMPK pathway to provide protection.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Urology & Nephrology
Haijian Ma, Xiaozhen Guo, Shichao Cui, Yongmei Wu, Yangming Zhang, Xiaoyan Shen, Cen Xie, Jingya Li
Summary: This study reveals that AMP-activated protein kinase (AMPK) plays an important protective role in tubular epithelial cells during acute kidney injury. The deficiency of AMPK leads to lipid droplet accumulation and elevated levels of ceramides and free fatty acids in the kidney tubules, resulting in worsened kidney impairment.
KIDNEY INTERNATIONAL
(2022)