期刊
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
卷 19, 期 1, 页码 324-335出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14686996.2018.1451717
关键词
Gas formation; magnesium alloys; biodegradable metals; clinical studies; 30 Bio-inspired and biomedical materials; 106 Metallic materials; 211 Scaffold; Tissue engineering; Drug delivery
资金
- CNUH-BRI (Biomedical Research Institute of Chonbuk National University Hospital) [CNUH-BRI-2012-02-005]
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [2014R1A4A1005309, 2015R1D1A1A01057144]
- National Research Foundation of Korea [2015R1D1A1A01057144] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Magnesium alloys are biodegradable metals receiving increasing attention, but the clinical applications of these materials are delayed by concerns over the rapid corrosion rate and gas formation. Unlike corrosion, which weakens mechanical properties, the gas formation issue has received little attention. Therefore, we evaluated the gas formation and biological effects for Mg implants through preclinical (immersed in Earle's balanced salt solution and in vivo) and clinical studies. The immersion test examined the gas volume and composition. The in vivo study also examined gas volume and histological analysis. The clinical study examined the gas volume and safety after Mg screw metatarsal fixation. Gas was mainly composed of H-2, CO and CO2. Maximum volumes of gas formed after 5days for in vivo and 7days in clinical study. Within the clinical examination, two superficial wound complications healed with local wound care. Osteolytic lesions in the surrounding metaphysis of the Mg screw insertion developed in all cases and union occurred at 3months. Mg implants released gas with variable volumes and composition (H-2, CO, and CO2), with no long-term toxic effects on the surrounding tissue. The implants enabled bone healing, although complications of wound breakdown and osteolytic lesions developed.
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