期刊
SCHIZOPHRENIA BULLETIN
卷 44, 期 5, 页码 958-965出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sby096
关键词
cacna1c; animal models; genetics; psychiatry; neurobiology; phenotypes; neurogenesis
类别
资金
- Medical Research Council
- Wellcome Trust Strategic Award [503147]
- MRC [MR/R011397/1] Funding Source: UKRI
Large-scale genome-wide association studies have consistently shown that genetic variation in CACNA1C, a gene that encodes calcium voltage-gated channel subunit alpha1C, increases risk for psychiatric disorders. CACNA1C encodes the Ca(v)1.2 subunit of voltage-gated calcium channels, which themselves have been functionally implicated in a broad spectrum of neuropsychiatric syndromes. Research has concentrated on uncovering the underlying biological mechanisms that could be responsible for this increased risk. This review presents an overview of recent findings regarding Cacna1c variation in animal models, particularly focusing on behavioral phenotypes associated with neurodevelopmental disorders such as cognition, anxiety and depressive phenotypes, and fear conditioning. The impact of reduced gene dosage of Cacna1c on adult hippocampal neurogenesis is also assessed, including new data from a novel Cacna1c(+/-) rat model.
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