Article
Immunology
Alison D. Petro, Joseph Dougherty, Bryant R. England, Harlan Sayles, Michael J. Duryee, Carlos D. Hunter, Joel M. Kremer, Dimitrios A. Pappas, William H. Robinson, Jeffrey R. Curtis, Geoffrey M. Thiele, Ted R. Mikuls
Summary: In rheumatoid arthritis patients, the number of positive autoantibodies is dose-dependently associated with treatment response to biologics, with anti-CCP antibody positivity having the strongest impact.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Susanne N. Wijesinghe, Mark A. Lindsay, Simon W. Jones
Summary: Research on osteoarthritis and rheumatoid arthritis has shown that oligonucleotide therapies may be a potential method to treat these diseases by modulating cellular pathways to alter joint pathology and prevent disease progression.
Article
Rheumatology
Muznay N. Khawaja, Eaman Alhassan, Jawad Bilal, Shraddha Jatwani, Bella Mehta, Varun Bhalla, Daniel J. Morgan, Bernadette C. Siaton, Marc C. Hochberg
Summary: Medical overuse can increase healthcare costs and potentially harm patients. Studies in musculoskeletal disease and rheumatology have identified cases of overtesting and overtreatment, such as unnecessary tests and excessive prescriptions. Efforts to reduce medical overuse include initiatives like the Choosing Wisely Campaign.
CLINICAL RHEUMATOLOGY
(2021)
Article
Engineering, Biomedical
Juan Wen, Huimin Li, Huan Dai, Shu Hua, Xing Long, Huang Li, Saso Ivanovski, Chun Xu
Summary: This review systematically summarizes nanoparticle-based therapies for the management of osteoarthritis (OA) and rheumatoid arthritis (RA). The interaction between nanoparticles and joint tissues, including articular fluids and cells, is explored. Current nanoparticles designed for OA/RA treatment are analyzed, and challenges and future clinical translation of nanoparticle-based therapies are discussed.
MATERIALS TODAY BIO
(2023)
Article
Multidisciplinary Sciences
Sung-Eun Choi, Haimuzi Xu, Ji-Hyoun Kang, Dong-Jin Park, Sun-Seog Kweon, Young-Hoon Lee, Hye-Yeon Kim, Jung-Kil Lee, Min-Ho Shin, Shin-Seok Lee
Summary: RHR is positively associated with the radiographic severity of knee joints but not hand joints in patients with musculoskeletal diseases like osteoarthritis. Adjusted for various factors, RHR shows positive correlations with total, osteophyte, JSN, and tibial attrition scores in knee joints and JSN and subchondral cyst scores in hand joints.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Sylvain Mathieu, C. Lambert, Francoise Fayet, Marion Couderc, Marine Beauger, Sandrine Malochet, Marie-Eva Pickering, Anne Tournadre, Martin Soubrier
Summary: Patients with rheumatoid arthritis (RA) and hand osteoarthritis (HOA) both have an increased cardiovascular risk, but the causes are still debated. This study compared the CV risk factors and risk scores between HOA and RA patients and found that RA patients had significantly higher risk scores than HOA patients. The difference in risk scores became non-significant when RA patients had low disease activity.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Orthopedics
Shawn C. Roll, Samantha H. Yo
Summary: This article proposes an expanded perspective on ergonomic approaches in hand therapy and explores published literature to identify potential benefits of applying ergonomic approaches for individuals with upper extremity arthritis. A systematic search and screening process was conducted to identify relevant articles, and the results showed positive outcomes for interventions employing ergonomics. The authors suggest that hand therapists can extend the scope of interventions by considering the use of emerging technologies and telehealth.
JOURNAL OF HAND THERAPY
(2022)
Article
Rheumatology
D. A. M. Thuy Trang, Koichi Okamura, Takahito Suto, Hideo Sakane, Yukio Yonemoto, Takahito Nakajima, Yoshito Tsushima, Hirotaka Chikuda
Summary: The study evaluated aortic wall inflammation in rheumatoid arthritis patients receiving biological treatment, finding that after 6 months of therapy, patients in remission or with low disease activity still had increased inflammatory activity at the aortic wall.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Medicine, General & Internal
Ewa Zelnio, Mihra Taljanovic, Malgorzata Manczak, Iwona Sudol-Szopinska
Summary: The hand and wrist are frequently involved in rheumatic diseases, and this study aimed to identify the distinguishing radiographic characteristics of psoriatic arthritis (PsA), seropositive rheumatoid arthritis (RA), and seronegative RA, especially in the early stages. The analysis of radiographic hand findings on 180 seropositive RA patients, 154 PsA patients, and 36 seronegative RA patients revealed that symmetric distribution of lesions was more suggestive of seropositive or seronegative RA, while lesions affecting PIP joints, wrist, or styloid process of the radius were more common in patients with seropositive RA. PsA was more likely to be suggested by DIP joints' involvement and proliferative bone changes. Furthermore, there were differences in the types of bone lesions and their distribution between seropositive RA, seronegative RA, and PsA, with ulnar styloid involvement more commonly seen in seronegative RA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kemal Ureten, Hadi Hakan Maras
Summary: In this study, a computer-aided diagnosis method using the YOLO algorithm and pre-trained VGG-16 network was developed to assist in interpreting hand radiographs in rheumatoid arthritis and osteoarthritis. The results showed high accuracy and sensitivity for the classification of different arthritis.
JOURNAL OF DIGITAL IMAGING
(2022)
Article
Rheumatology
Mingyue Cheng, Yan Zhao, Yazhou Cui, Chaofang Zhong, Yuguo Zha, Shufeng Li, Guangxiang Cao, Mian Li, Lei Zhang, Kang Ning, Jinxiang Han
Summary: This study investigated the role of microbial dysbiosis and metabolic disorders in different stages of rheumatoid arthritis (RA). The findings suggest that microbial dysbiosis and metabolic disorders exhibit distinct patterns and play stage-specific roles in RA. This provides new insights for prognosis and therapy of RA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Jacqueline Uson, Sebastian Cruz Rodriguez-Garcia, Raul Castellanos-Moreira, Terence W. O'Neill, Michael Doherty, Mikael Boesen, Hemant Pandit, Ingrid Moller Parera, Valentina Vardanyan, Lene Terslev, Willm Uwe Kampen, Maria-Antonietta D'agostino, Francis Berenbaum, Elena Nikiphorou, Irene A. Pitsillidou, Jenny de la Torre-Aboki, Loreto Carmona, Esperanza Naredo
Summary: The study established evidence and expert opinion-based recommendations to guide health professionals using intra-articular therapies in adult patients with peripheral arthropathies. The recommendations focus on practical aspects to guide health professionals before, during, and after IAT in adult patients, covering a wide range of considerations that should be taken into account in practice.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Yanqiu Zhu, Jiatian Li, Yuqing Zhang, Weiya Zhang, Michael Doherty, Zidan Yang, Yang Cui, Chao Zeng, Guanghua Lei, Tuo Yang, Jie Wei
Summary: In this population-based study, we found an association between hyperuricaemia and a higher prevalence of hand osteoarthritis.
Review
Biochemistry & Molecular Biology
Iona J. MacDonald, Chien-Chung Huang, Shan-Chi Liu, Yen-You Lin, Chih-Hsin Tang
Summary: The CCN family of matricellular proteins play essential roles in processes like angiogenesis, wound healing, and inflammation, particularly in the inflammatory pathologies of rheumatoid arthritis and osteoarthritis. Several proteins within the CCN family are thought to be potential therapeutic targets for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Theoharris Frangos, Wolfgang Maret
Summary: Zinc and cadmium play crucial roles in osteoarthritis and rheumatoid arthritis, affecting the immune system, inflammation, and metabolism. The mutations in proteins involved in zinc homeostasis and cadmium exposure through inhalation may contribute to joint destruction.
Article
Rheumatology
Delphine S. Courvoisier, Katarina Chatzidionysiou, Denis Mongin, Kim Lauper, Xavier Mariette, Jacques Morel, Jacques-Eric Gottenberg, Sytske Anne Bergstra, Manuel Pombo Suarez, Catalin Codreanu, Tore K. Kvien, Maria Jose Santos, Karel Pavelka, Merete L. Hetland, Johan Askling, Carl Turesson, Satoshi Kubo, Yoshiya Tanaka, Florenzo Iannone, Denis Choquette, Dan C. Nordstrom, Ziga Rotar, Galina Lukina, Cem Gabay, Ronald Van Vollenhoven, Axel Finckh
Summary: This study compared the impact of seropositivity on drug discontinuation and effectiveness of bDMARDs in patients with RA in a real-world setting. The findings suggest that seropositivity is associated with increased effectiveness of non-TNFi bDMARDs, especially RTX and ABA, but not TNFis.
Article
Rheumatology
Johanna M. Maassen, Sytske Anne Bergstra, Arvind Chopra, Nimmisha Govind, Elizabeth A. Murphy, David Vega-Morales, Tom W. J. Huizinga, Cornelia F. Allaart
Summary: This study found that RA patients onset above 65 years old include more men and seronegative arthritis, and were initially treated slightly differently than younger patients. However, there were no clinically relevant differences in timing of a next treatment step or response to treatment between different age groups.
Article
Rheumatology
Mrinalini Dey, Sizheng S. Zhao, Robert J. Moots, Sytske Anne Bergstra, Robert B. Landewe, Nicola J. Goodson
Summary: This study aimed to explore the association between increased BMI and the response to conventional synthetic DMARDs in patients with rheumatoid arthritis (RA). The study found that in patients with established RA, obese individuals were less likely to achieve a good treatment response and were more likely to be treated with combination therapy. Additionally, overweight and obese patients were exposed to higher doses of MTX medication.
Article
Rheumatology
Sascha L. Heckert, Sytske Anne Bergstra, Xanthe M. E. Matthijssen, Yvonne P. M. Goekoop-Ruiterman, Faouzia Fodili, Saskia Ten Wolde, Cornelia F. Allaart, Tom W. J. Huizinga
Summary: In patients with rheumatoid arthritis, baseline joint swelling was significantly associated with swelling in the same joint during follow-up, and it was found to better predict local joint swelling compared to baseline swelling in other joints. This suggests that local factors play a role in the recurrence of joint swelling over time.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Lotte A. van de Stadt, Feline P. B. Kroon, Frits R. Rosendaal, Desiree van der Heijde, Monique Reijnierse, Naghmeh Riyazi, Ragnhild de Slegte, Jende van Zeben, Cornelia F. Allaart, Margreet Kloppenburg, Marion C. Kortekaas
Summary: The agreement between real-time and static ultrasonography was studied in inflammatory hand OA, finding good agreement at joint level and moderate to excellent agreement at patient level. Real-time ultrasonography showed responsiveness to prednisone therapy, while static ultrasonography did not. Therefore, real-time dynamic scoring should remain the standard in clinical trials.
Article
Rheumatology
Lara J. Maxwell, Dorcas E. Beaton, Maarten Boers, Maria Antonietta D'Agostino, Philip G. Conaghan, Shawna Grosskleg, Beverley J. Shea, Clifton O. Bingham, Annelies Boonen, Robin Christensen, Ernest Choy, Andrea S. Doria, Catherine L. Hill, Catherine Hofstetter, Feline Pb Kroon, Ying Ying Leung, Sarah Mackie, Alexa Meara, Zahi Touma, Peter Tugwell, George A. Wells
Summary: This article presents the methods of OMERACT Filter 2.2 for assessing and selecting instruments in core outcome sets, focusing on rigorous evaluation of measurement properties and transparent reporting. By improving documentation and processes, OMERACT aims to enhance the transparency and accuracy in assessing instruments.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Rheumatology
Feline P. B. Kroon, Desiree van der Heijde, Lara J. Maxwell, Dorcas E. Beaton, Abishek Abishek, Francis Berenbaum, Francisco J. Blanco, Philip G. Conaghan, Krysia Dziedzic, Catherine L. Hill, Ida K. Haugen, Mariko Ishimori, Valentin Ritschl, Tanja A. Stamm, Ruth Wittoek, Margreet Kloppenburg
Summary: The study aimed to select appropriate instruments to measure physical function as a core outcome domain in hand osteoarthritis studies. The Michigan Hand Outcomes Questionnaire (MHQ) passed the assessment for domain match and feasibility, while AUSCAN had limitations in feasibility but good domain match. Both MHQ and AUSCAN fulfilled OMERACT standards for reliability and validity.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Letter
Hematology
Inge H. Y. Luu, Feline P. B. Kroon, Jacqueline Buijs, Jasenko Krdzalic, Martijn D. de Kruif, Math P. G. Leers, Guy J. M. Mostard, Remy J. H. Martens, Remy L. M. Mostard, Daan J. L. van Twist
THROMBOSIS RESEARCH
(2021)
Review
Rheumatology
Feline P. B. Kroon, Aurelie Najm, Alessia Alunno, Jan W. Schoones, Robert B. M. Landewe, Pedro M. Machado, Victoria Navarro-Compan
Summary: This systematic literature review on patients with rheumatic and musculoskeletal diseases (RMDs) examined the risk and prognosis of SARS-CoV-2 infection as well as the vaccination against SARS-CoV-2. Most studies indicated that individuals with RMDs do not have a higher risk of contracting SARS-CoV-2 or experiencing worse COVID-19 outcomes compared to those without RMDs. Disease activity and medication use may influence the prognosis of COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Robert B. M. Landewe, Feline P. B. Kroon, Alessia Alunno, Aurelie Najm, Johannes W. J. Bijlsma, Gerd-Ruediger R. Burmester, Roberto Caporali, Bernard Combe, Richard Conway, Jeffrey R. Curtis, Ori Elkayam, Laure Gossec, Marloes W. Heijstek, Lukas Haupt, Annamaria Iagnocco, John D. Isaacs, Istvan Abel Juhasz, Suzi Makri, Xavier Mariette, Iain B. McInnes, Puja Mehta, Ulf Mueller-Ladner, Hendrik Schulze-Koops, Josef S. Smolen, Dieter Wiek, Kevin L. Winthrop, Victoria Navarro-Compan, Pedro M. Machado
Summary: This article presents the first provisional recommendations on the management of RMDs in the context of SARS-CoV-2 by EULAR, followed by updates and studies on vaccination and additional doses.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Anesthesiology
Coen van der Meulen, Lotte A. van de Stadt, Feline P. B. Kroon, Marion C. Kortekaas, Annelies E. R. C. H. Boonen, Stefan Bohringer, Marieke Niesters, Monique Reijnierse, Frits R. Rosendaal, Naghmeh Riyazi, Mirian Starmans-Kool, Franktien Turkstra, Jende van Zeben, Cornelia F. Allaart, Margreet Kloppenburg
Summary: In this study, 16% of inflammatory hand OA patients experienced neuropathic-like pain, which was more common in females, associated with more comorbidities, and led to lower quality of life. Neuropathic-like pain symptoms persisted despite prednisolone treatment and did not affect the efficacy of prednisolone treatment.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Rheumatology
Lotte A. van de Stadt, Feline P. B. Kroon, Christian F. Thudium, Anne C. Bay-Jensen, Margreet Kloppenburg
Summary: This study found that higher levels of C1M and hsCRP were associated with erosive hand OA, but these biomarkers were not influenced by treatment with prednisolone. The current biomarkers were not able to predict the response to prednisolone in hand OA.
Review
Rheumatology
Coen van der Meulen, Lotte A. van de Stadt, Aniek Claassen, Feline P. B. Kroon, Marco J. P. F. Ritt, Frits R. Rosendaal, Sietse E. S. Terpstra, Anne J. H. Vochteloo, Margreet Kloppenburg
Summary: Surgical denervation has been proposed as a treatment for pain in hand osteoarthritis (OA). This review aimed to summarise the available evidence and propose a research agenda. The available evidence suggests that surgical denervation may be effective for pain in hand OA, but higher-quality research is needed for conclusive results.
Review
Rheumatology
Anna Dossing, Sabrina Mai Nielsen, Feline P. B. Kroon, Ida Maria Balsby, Simon Tarp, Margreet Kloppenburg, Lisa Stamp, Ida K. Haugen, Roy D. Altman, Marius Henriksen, Mikael Boesen, Henning Bliddal, Soren Berg, Robin Christensen
Summary: Oral NSAIDs and glucocorticoids are effective pharmacological interventions for hand osteoarthritis, while intra-articular therapies and topical NSAIDs are not superior to placebo.
Meeting Abstract
Rheumatology
C. F. Allaart, Sytske Anne Bergstra, Tom Huizinga, Joy van der Pol
ARTHRITIS & RHEUMATOLOGY
(2022)