☆ 4.0 Review

A Review of Osteoporosis in the Older Adult: An Update

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2018)

期刊

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

卷 44, 期 3, 页码 437-+

出版社

W B SAUNDERS CO-ELSEVIER INC

DOI: 10.1016/j.rdc.2018.03.004

关键词

Osteoporosis; Bisphosphonates; FRAX; Drug holiday; Hip fractures; Elderly; DXA

类别

Rheumatology

向作者/读者索取更多资源

Protocol

Reagent

摘要

Osteoporosis in the elderly population is common. It results in more than 1.5 million fractures per year in the United States. The goal of managing osteoporosis is to prevent fractures. In men, osteoporosis is underrecognized and undertreated. More men than women die every year as a consequence of hip fractures. Bisphosphonates are the first-line treatment of men and women. In the past several years, advances in bone biology have resulted in major therapeutic advances. This article reviews the diagnosis and treatment of osteoporosis.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.0

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Endocrinology & Metabolism

Vertebral Fractures in Ireland: A Sub-analysis of the DXA HIP Project

John J. Carey, Lan Yang, E. Erjiang, Tingyan Wang, Kelly Gorham, Rebecca Egan, Attracta Brennan, Mary Dempsey, Catherine Armstrong, Fiona Heaney, Eva McCabe, Ming Yu

Summary: Osteoporosis is a global health issue, with vertebral fractures being common in older men and women with low bone mineral density, previous fractures, and at high risk of future fractures. Urgent attention is needed to identify those at risk and reduce the burden of vertebral fractures. Ireland has high hip fracture rates but limited data on vertebral fractures, indicating the need for further research in this area.

CALCIFIED TISSUE INTERNATIONAL (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Patterns of Osteoporosis Medications Selection After Drug Holiday or Continued Therapy: A Real-World Experience

Michael Morkos, Paul Mahrous, Alessandra Casagrande, Muriel Tania Go, Hasan Husni, Mirette Hanna, Mishita Goel, Sara Bedrose, Dingfeng Li, Sanford Baim

Summary: This study aimed to investigate physicians' preferences and sequential treatment patterns of osteoporosis therapy. The study found that alendronate was the most common initial treatment, and denosumab was the most common second course of treatment prescribed.

ENDOCRINE PRACTICE (2022)

添加到收藏夹

Article Endocrinology & Metabolism

High prevalence and undertreatment of osteoporosis in elderly patients undergoing total hip arthroplasty

M. M. Delsmann, A. Strahl, M. Muhlenfeld, N. M. Jandl, F. T. Beil, C. Ries, T. Rolvien

Summary: The study found a high prevalence of low bone mineral density in elderly patients with end-stage osteoarthritis scheduled for total hip arthroplasty. Routine DXA measurements should be considered in these patients to prevent undiagnosed and untreated osteoporosis, which could impact the success of osseointegration and other clinical outcomes.

OSTEOPOROSIS INTERNATIONAL (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Bone Radiomics Score Derived From DXA Hip Images Enhances Hip Fracture Prediction in Older Women

Namki Hong, Heajeong Park, Chang Oh Kim, Hyeon Chang Kim, Jin-Young Choi, Hwiyoung Kim, Yumie Rhee

Summary: Dual-energy X-ray absorptiometry (DXA)-based bone radiomics scores from hip images may improve hip fracture prediction in older women. The study showed that an increase in bone radiomics score was associated with an elevated risk of incident hip fracture.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Predictive Value of DXA Appendicular Lean Mass for Incident Fractures, Falls, and Mortality, Independent of Prior Falls, FRAX, and BMD: Findings from the Women's Health Initiative (WHI)

Nicholas C. Harvey, John A. Kanis, Enwu Liu, Cyrus Cooper, Mattias Lorentzon, Jennifer W. Bea, Laura Carbone, Elizabeth M. Cespedes Feliciano, Deepika R. Laddu, Peter F. Schnatz, Aladdin H. Shadyab, Marcia L. Stefanick, Jean Wactawski-Wende, Carolyn J. Crandall, Helena Johansson, Eugene McCloskey

Summary: In the WHI study, associations between baseline appendicular lean mass (ALM) and incident fractures, falls, and mortality in older postmenopausal women were investigated. Higher ALM/height(2) was associated with lower risk of MOF but higher risk of death. These associations were independent of prior falls but attenuated by other factors such as FRAX probability and FN BMD T-score.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Performance of FRAX in Men With Prostate Cancer: A Registry-Based Cohort Study

Carrie Ye, Suzanne N. Morin, Lisa M. Lix, Eugene V. McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie

Summary: The study assessed the performance of the Fracture Risk Assessment Tool (FRAX) in predicting incident fractures in men with prostate cancer. The results showed that FRAX reliably predicts fractures in this population.

JOURNAL OF BONE AND MINERAL RESEARCH (2023)

添加到收藏夹

Article Medicine, General & Internal

Clinical Significance of Discordance between Hip and Spine Bone Mineral Density in Korean Elderly Patients with Hip Fractures

Se-Won Lee, Younghyun Yoon, Junhyuk Kwon, Jun-Young Heu, Jihyo Hwang

Summary: The clinical significance of BMD discordance between the hip and spine for hip fractures was evaluated in this study. The results showed that the rates of BMD discordance and low hip discordance were significantly higher in the hip fracture group than in the non-fracture group, indicating a higher risk of hip fractures.

JOURNAL OF CLINICAL MEDICINE (2023)

添加到收藏夹

Article Endocrinology & Metabolism

3D Finite Element Models Reconstructed From 2D Dual-Energy X-Ray Absorptiometry (DXA) Images Improve Hip Fracture Prediction Compared to Areal BMD in Osteoporotic Fractures in Men (MrOS) Sweden Cohort

Lorenzo Grassi, Sami P. P. Vaananen, Lars Jehpsson, Osten Ljunggren, Bjorn E. Rosengren, Magnus K. K. Karlsson, Hanna Isaksson

Summary: This study evaluated the ability of a method to predict incident hip fractures based on the reconstruction of 3D hip anatomy from a 2D DXA image and subject-specific FE-based prediction of proximal femoral strength. The results showed that FE-predicted proximal femoral strength was a better predictor of hip fractures than aBMD, suggesting potential for improving fracture risk predictions in a clinically feasible manner.

JOURNAL OF BONE AND MINERAL RESEARCH (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Functional Analyses of Four CYP1A1 Missense Mutations Present in Patients with Atypical Femoral Fractures

Nerea Ugartondo, Nuria Martinez-Gil, Monica Esteve, Natalia Garcia-Giralt, Neus Roca-Ayats, Diana Ovejero, Xavier Nogues, Adolfo Diez-Perez, Raquel Rabionet, Daniel Grinberg, Susanna Balcells

Summary: Osteoporosis, a common metabolic bone disorder, is often treated with nitrogen-containing bisphosphonates. Prolonged use of bisphosphonates may lead to rare atypical femoral fractures, possibly due to rare mutations in the CYP1A1 gene.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Medicine, General & Internal

Duration of Bisphosphonate Drug Holidays in Osteoporosis Patients: A Narrative Review of the Evidence and Considerations for Decision-Making

Kaleen N. Hayes, Elizabeth M. Winter, Suzanne M. Cadarette, Andrea M. Burden

Summary: Bisphosphonates are the primary treatment for osteoporosis, and a drug holiday of two to three years is recommended for most patients after long-term use to reduce the risk of adverse events. Duration of bisphosphonate effects during the drug holiday and individual patient factors should be considered when determining the appropriate time to stop therapy.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Review Medicine, General & Internal

Bilateral Atypical Femoral Fractures after Bisphosphonate Treatment for Osteoporosis: A Literature Review

SeokJoon Hwang, Minsu Seo, Dongin Lim, Min Suk Choi, Jin-Woo Park, Kiyeun Nam

Summary: This literature review investigated the characteristics and management of bisphosphonate-associated bilateral atypical femoral fractures (AFFs). A comprehensive analysis of 43 patients with bilateral AFFs revealed that 67% had prodromal symptoms, 49% occurred simultaneously, and 51% occurred sequentially. X-ray was used for initial diagnosis, with 53% having complete fractures. Surgical treatment was performed for all patients, except for those with incomplete fractures who received either surgical or medical treatments. Teriparatide was the most commonly used medication after bisphosphonate discontinuation.

JOURNAL OF CLINICAL MEDICINE (2023)

添加到收藏夹

Article Environmental Sciences

Bisphosphonate Use and Hospitalization for Hip Fractures in Women: An Observational Population-Based Study in France

Bastien Bourrion, Cecile Souty, Lucie Fournier, Ana-Maria Vilcu, Thierry Blanchon, Pierre-Yves Boelle, Thomas Hanslik, Mathilde Francois

Summary: The study found that in real life, the use of bisphosphonates does not appear to reduce hospitalization rates for hip fractures, possibly due to it being prescribed for primary prevention and for a duration too short to be effective.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Frailty and osteoporosis in patients with hip fractures under the age of 60-a prospective cohort of 218 individuals

Sebastian Strom Ronnquist, Bjarke Viberg, Morten Tange Kristensen, Henrik Palm, Jens-Erik Beck Jensen, Carsten Fladmose Madsen, Kristina E. Akesson, Soren Overgaard, Cecilia Rogmark

Summary: Research on younger patients with hip fractures is limited. This study provides valuable knowledge about patient and injury characteristics, and explores the role of DXA in assessing bone mineral density at the time of fracture. Risk factors for osteoporosis and fractures were found to be abundant among young patients, with a much higher prevalence of osteoporosis compared to the general population.

OSTEOPOROSIS INTERNATIONAL (2022)

添加到收藏夹

Article Critical Care Medicine

Patients' first-year adherence to different anti-osteoporotic therapy after hip fractures

Seung-Ju Kim, Yun Jae Cho, Dong-Woo Lee

Summary: This study found low adherence to osteoporosis treatments in elderly patients following hip fracture, with 6-month subcutaneous denosumab injection being the preferred choice and exhibiting significantly lower discontinuation rates.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2021)

添加到收藏夹

Review Critical Care Medicine

Atypical periprosthetic femoral fractures of the hip: A PRISMA compliant systematic review

Annalisa De Cicco, Giuseppe Toro, Francesco Oliva, Umberto Tarantino, Alfredo Schiavone Panni, Nicola Maffulli

Summary: The study analyzed 17 patients with APFF, finding that all cases occurred in females with an average age of 75.9 years. Conservative management was effective for incomplete fractures, while complete fractures required open reduction and internal fixation. The study suggests that APFF shares many clinical and imaging characteristics with AFF.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2021)

添加到收藏夹

暂无数据

Article Rheumatology

J. Claude Bennett, MD: Scholar, Physician, and Leader

S. Louis Bridges, Steffen Gay

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

H. Ralph Schumacher

Joshua F. Baker, Daniel G. Baker

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

Hal Holman of Stanford

William Neal Roberts Jr, Edward R. Lew, Matthew H. Liang

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

Nathan Zvaifler

Daniel A. Albert

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

Gerald P Rodnan

Virginia D. Steen, Thomas A. Medsger

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

Eric Bywaters and Barbara Ansell Founders of Modern Pediatric Rheumatology

Patricia Woo, Ross E. Petty

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

John R. Ward, MD: Pioneer- Clinical Trials in Rheumatology

H. James Williams, Grant W. Cannon, Daniel O. Clegg

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Biographical-Item Rheumatology

Edmund Lawrence Dubois (1923-1985)

Daniel J. Wallace

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

Daniel J McCarty, MD: A Giant of Rheumatology

Ann K. Rosenthal, Mary E. Csuka, Paul Halverson

Summary: Dr. McCarty is a giant in the field of rheumatology. His clinical and scientific discoveries have had a major impact and benefited many patients. He has been an exceptional mentor and role model, influencing our clinical practice styles, the importance we place on clinical observation, and our approach to scientific questions.

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

Naomi Rothfield, MD, MACR A Giant Gift in a Small Package

Arthur Weinstein

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

The Giants of Rheumatology at Johns Hopkins

Marc C. Hochberg

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

E Carwile LeRoy, MD

Richard M. Silver

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

Walter Bauer, Marian Wilkins Ropes, and the Massachusetts General Hospital

Anthony M. Reginato, Michelle A. Petri, Jonathan Kay

Summary: Bauer and Ropes were influential figures in the field of rheumatology, making significant contributions through clinical observation and laboratory research. They were also exceptional mentors and leaders in the field.

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

Charles L Christian Model Physician Scientist and Mentor

Mary K. Crow, Josef S. Smolen

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

Article Rheumatology

Lessons from Carl M. Pearson 1919-1981

James S. Louie

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2024)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.