An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation

Molecular Dynamics Simulations Reveal an Interplay between SHAPE Reagent Binding and RNA Flexibility

(2018) Vojtěch Mlýnský et al.   Journal of Physical Chemistry Letters

A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease

(2017) Matthew Brecher et al.   PLoS Pathogens

Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA

(2016) Fardokht A. Abulwerdi et al.   JOURNAL OF MEDICINAL CHEMISTRY

NMR detection of intermolecular interaction sites in the dimeric 5′-leader of the HIV-1 genome

(2016) Sarah C. Keane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic differences between HIV-1 and SIV nucleocapsid proteins and cross-species HIV-1 genomic RNA recognition

(2016) Klara Post et al.   Retrovirology

Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1

(2016) Chris Hellmund et al.   Viruses-Basel

On the Selective Packaging of Genomic RNA by HIV-1

(2016) Mauricio Comas-Garcia et al.   Viruses-Basel

HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors

(2015) Paul Spearman   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro

(2015) Marc Potempa et al.   JOURNAL OF MOLECULAR BIOLOGY

Dimerization of the SP1 Region of HIV-1 Gag Induces a Helical Conformation and Association into Helical Bundles: Implications for Particle Assembly

(2015) Siddhartha A. K. Datta et al.   JOURNAL OF VIROLOGY

Targeted binding of nucleocapsid protein transforms the folding landscape of HIV-1 TAR RNA

(2015) Micah J. McCauley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In virio SHAPE analysis of tRNALys3 annealing to HIV-1 genomic RNA in wild type and protease-deficient virus

(2015) Elias Seif et al.   Retrovirology

Structure of the HIV-1 RNA packaging signal

(2015) S. C. Keane et al.   SCIENCE

The HIV-1 leader RNA is exquisitely sensitive to structural changes

(2015) Nikki van Bel et al.   VIROLOGY

Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays

(2014) Joanna Sztuba-Solinska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting RNA–Protein Interactions within the Human Immunodeficiency Virus Type 1 Lifecycle

(2013) Neil M. Bell et al.   BIOCHEMISTRY

In-gel probing of individual RNA conformers within a mixed population reveals a dimerization structural switch in the HIV-1 leader

(2013) Julia C. Kenyon et al.   NUCLEIC ACIDS RESEARCH

Three-Dimensional RNA Structure of the Major HIV-1 Packaging Signal Region

(2013) James D. Stephenson et al.   STRUCTURE

Comparative Structural Effects of HIV-1 Gag and Nucleocapsid Proteins in Binding to and Unwinding of the Viral RNA Packaging Signal

(2012) Neil M. Bell et al.   BIOCHEMISTRY

HIV-2 Genome Dimerization Is Required for the Correct Processing of Gag: a Second-Site Reversion in Matrix Can Restore Both Processes in Dimerization-Impaired Mutant Viruses

(2012) A. L'Hernault et al.   JOURNAL OF VIROLOGY

HIV Type 1 Gag as a Target for Antiviral Therapy

(2011) Abdul A. Waheed et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Structural Determinants and Mechanism of HIV-1 Genome Packaging

(2011) Kun Lu et al.   JOURNAL OF MOLECULAR BIOLOGY

SHAPE analysis of the FIV Leader RNA reveals a structural switch potentially controlling viral packaging and genome dimerization

(2011) Julia C. Kenyon et al.   NUCLEIC ACIDS RESEARCH

NMR Detection of Structures in the HIV-1 5'-Leader RNA That Regulate Genome Packaging

(2011) K. Lu et al.   SCIENCE

RNAstructure: software for RNA secondary structure prediction and analysis

(2010) Jessica S Reuter et al.   BMC BIOINFORMATICS

Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat

(2010) Catherine S. Adamson et al.   Retrovirology

HIV-1 Gag Processing Intermediates Trans-dominantly Interfere with HIV-1 Infectivity

(2009) Barbara Müller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Strongly Transdominant Mutation in the Human Immunodeficiency Virus Type 1 gag Gene Defines an Achilles Heel in the Virus Life Cycle

(2009) S.-K. Lee et al.   JOURNAL OF VIROLOGY

Detecting HIV-1 integration by repetitive-sampling Alu-gag PCR

(2009) Megan K. Liszewski et al.   METHODS

ShapeFinder: A software system for high-throughput quantitative analysis of nucleic acid reactivity information resolved by capillary electrophoresis

(2008) S. M. Vasa et al.   RNA

High-Throughput SHAPE Analysis Reveals Structures in HIV-1 Genomic RNA Strongly Conserved across Distinct Biological States

(2008) Kevin A Wilkinson et al.   PLOS BIOLOGY