Article
Medicine, General & Internal
Zhengwei Zhang, Xiaona Bao, Zhifeng Wu, Jie Zhang
Summary: Half-dose or reduced-fluence photodynamic therapy (PDT) with verteporfin is recognized as an effective treatment for chronic central serous chorioretinopathy (CSC). However, a case was reported where choroidal neovascularization (CNV) developed only 3 weeks after such treatment, which had not been reported before. The patient was successfully treated with intravitreal injections of aflibercept after developing CNV.
Article
Ophthalmology
Jingli Guo, Wenyi Tang, Wei Liu, Qing Chang, Gezhi Xu
Summary: This study described the multimodal imaging characteristics of flat irregular pigment epithelial detachment (FIPED) in patients with chronic central serous chorioretinopathy and determined risk factors for vascularized FIPED. Vascularized FIPED was closely associated with Type I choroidal neovascularization and old age was identified as an independent risk factor for vascularized FIPED. Vascularized FIPED was suggested as quiescent choroidal neovascularization, and half-dose photodynamic therapy may be recommended as the first-line therapy in chronic central serous chorioretinopathy complicated with quiescent choroidal neovascularization.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Medicine, General & Internal
Woo Hyuk Lee, Bum Jun Kim, Yong Seop Han
Summary: This study presents a case of bilateral spontaneous large RPE tears in a patient with acute CSC without bullous RD, leading to decreased visual acuity. The findings suggest that large PED and old age may play a role in the development of RPE tears in CSC patients, emphasizing the importance of careful treatment consideration in such cases.
Article
Ophthalmology
Sungsoon Hwang, Hoon Noh, Se Woong Kang, Min Chae Kang, Dongyoung Lee, Sang Jin Kim
Summary: This study investigated the incidence, risk factors, and clinical outcomes of complicated CNV after reduced-fluence PDT for central serous chorioretinopathy. The results showed that around 1% of patients may develop CNV after treatment, but it can be effectively controlled with anti-VEGF injections. Additionally, flat irregular pigment epithelial detachment was found to increase the risk of secondary CNV following PDT.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Yang Meng, Liao Chen, Lu Li, Yishuang Xu, Yu Su, Lu Zhang, Zuohuizi Yi, Changzheng Chen
Summary: This article reports a rare case of a patient with central serous chorioretinopathy whose pigment epithelial detachment (PED) exhibited time-dependent recurrence and resolution. The abnormal diurnal variation of cortisol was considered as the internal factor affecting PED. This finding may provide new insights for the treatment strategy of central serous chorioretinopathy.
Article
Oncology
Jale Mentes, Zafer Oztas, Hamidu Hamisi Gobeka
Summary: This report aimed to determine if pupil-dilating eye drops affected serous pigment epithelial detachment elevation in an eye with central serous chorioretinopathy. The findings showed that dilation of the pupil increased the elevation of pigment epithelial detachment, indicating the potential influence of pupil dilation on central serous chorioretinopathy.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Ophthalmology
Helena M. A. Feenstra, Leo C. Hahn, Thomas J. van Rijssen, Roula Tsonaka, Myrte B. Breukink, Jan E. E. Keunen, Petrus J. H. Peters, Greet Dijkman, Eric H. Souied, Robert E. MacLaren, Giuseppe Querques, Susan M. Downes, Sascha Fauser, Carel B. Hoyng, Elon H. C. van Dijk, Camiel J. F. Boon
Summary: The study compared the effectiveness of half-dose photodynamic therapy and high-density subthreshold micropulse laser treatment on retinal pigment epithelial detachments (PEDs) in chronic central serous chorioretinopathy. It found that half-dose photodynamic therapy was superior in reducing the height of macular PEDs compared to high-density subthreshold micropulse laser treatment. These findings may have implications for the treatment of other diseases with PEDs.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Medicine, General & Internal
Yongyue Su, Xiongze Zhang, Yuhong Gan, Yuying Ji, Feng Wen
Summary: This study found that in chronic central serous chorioretinopathy (CSC), eyes with vascularized FIPED have larger width, greater RPE thickness, and more RPE aggregations in the FIPED area. RPE aggregations in the FIPED area are an independent factor strongly associated with vascularized FIPED.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Masahiro Miura, Shuichi Makita, Yoshiaki Yasuno, Takuya Iwasaki, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi
Summary: The study quantitatively evaluated retinal pigment epithelium changes in patients with age-related macular degeneration using prototype multi-contrast optical coherence tomography. The results showed that multi-contrast OCT is useful for objective evaluation of changes in the retinal pigment epithelium.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Argyrios Chronopoulos, Vinodh Kakkassery, Marc Andre Strobel, Luise Fornoff, Lars-Olof Hattenbach
Summary: The presence and form of pigment epithelial detachment may play a role in the course of central serous chorioretinopathy. While corticosteroid use was not found to be correlated with the onset of the disease in this study, further research is needed to confirm these findings.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
E. Bousquet, J. Provost, H. Torres-Villaros, F. Behar-Cohen
Summary: Central serous chorioretinopathy is a condition characterized by retinal detachments and pigment epithelium detachments/irregularities. It mainly affects middle-aged men, with corticosteroid intake being a major risk factor. While most cases resolve spontaneously, recurrent or chronic forms of the disease can cause significant retinal damage and decreased visual acuity. Laser treatment and photodynamic therapy are common treatment options.
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2023)
Article
Ophthalmology
Mengyang Li, Jinfeng Qu, Zhiqiao Liang, Jiyang Tang, Jie Hu, Yuou Yao, Enzhong Jin, Xiaoxin Li, Mingwei Zhao
Summary: In this study, factors such as long duration of symptoms, larger baseline SRF area, and larger FI-PED base diameter on SD-OCT were identified as important risk factors for incomplete SRF absorption after half-dose vPDT. Further research is needed to develop better treatment strategies for patients with poor response to this therapy.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Jeewoo Yoon, Jinyoung Han, Junseo Ko, Seong Choi, Ji In Park, Joon Seo Hwang, Jeong Mo Han, Kyuhwan Jang, Joonhong Sohn, Kyu Hyung Park, Daniel Duck-Jin Hwang
Summary: This study developed a deep learning system model to distinguish subtypes of central serous chorioretinopathy (CSC) using a convolutional neural network (CNN). The model showed high accuracy in classifying CSC subtypes, indicating the potential usefulness of automated deep learning systems in the classification and management of CSC.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yuying Ji, Yuhong Gan, Yongyue Su, Yining Zhang, Miaoling Li, Lan Mi, Chengguo Zuo, Feng Wen
Summary: This study found that macular pigment optical density (MPOD) decreased within 7 degrees of eccentricity in patients with acute central serous chorioretinopathy (CSC), but there were no changes in serum lutein and zeaxanthin levels. The decrease in MPOD may be due to subretinal fluid. Further investigation is needed to determine the involvement of local oxidative stress in CSC and whether supplementation with lutein and zeaxanthin is beneficial.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yukihiro Aoyama, Ichiro Maruko, Taizo Kawano, Tatsuro Yokoyama, Yuki Ogawa, Ruka Maruko, Tomohiro Iida
Summary: Deep learning can diagnose central serous chorioretinopathy (CSC) with high accuracy from en face images of the choroidal vasculature, using different programs, convolutional layer structures, and small data sets. Heatmap analyses reveal that DL focuses on the area occupied by the choroidal vessels and their uniformity.