Article
Chemistry, Multidisciplinary
Solmaz Abdolrahimzadeh, Serena Fragiotta, Chiara Ciacimino, Mariachiara Di Pippo, Gianluca Scuderi
Summary: The study found that eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD) have higher choroidal vascularity index (CVI), particularly in terms of increased luminal area, suggesting a potential role of choroidal vasculature in the pathological process of AOFVD disease.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Ioana Damian, George-Adrian Muntean, Larisa-Bianca Galea-Holhos, Simona-Delia Nicoara
Summary: This study characterized the evolution of acquired vitelliform lesions (AVLs) in patients with age-related macular degeneration (AMD) using optical coherence tomography (OCT) technology and ImageJ software. The results showed increased thickness of the retinal pigment epithelium (RPE) in the central quadrant and decreased thickness of the outer nuclear layer (ONL) in the vitelliform group compared to the control group. The impact of AVLs on the retina was associated with the presence of a continuous external limiting membrane (ELM) and ellipsoid zone (EZ).
Article
Multidisciplinary Sciences
Naoki Soga, Shin Tanaka, Maiko Inoue, Tatsuya Inoue, Atsushi Hayashi, Eugene de Juan Jr, Kazuaki Kadonosono
Summary: This study compared macular vessel density in CRAO eyes treated with retinal arterial cannulation and standard treatment. The cannulation group showed significant improvement in macular vessel density after 7 days, while the standard treatment group did not show significant improvement. After one month, the cannulation group had significantly improved visual acuity compared to the initial visit after the onset.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Eva Feodora Romahn, Tun Wiltgen, Matthias Bussas, Lilian Aly, Rebecca Wicklein, Christina Noll, Achim Berthele, Vera Dehmelt, Christian Mardin, Claus Zimmer, Thomas Korn, Bernhard Hemmer, Jan S. Kirschke, Mark Muehlau, Benjamin Knier
Summary: Optical coherence tomography angiography can assess retinal vessel structures in patients with multiple sclerosis. The thinning and loss of retinal vessels are associated with brain atrophy and disability in multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Ophthalmology
Or Shmueli, Rivkah Lender, Yahel Shwartz, Itay Chowers, Liran Tiosano
Summary: This study aimed to understand the pathogenesis of adult-onset foveomacular vitelliform dystrophy (AFVD) by assessing its pseudohypopyon stage (PHS). Results showed that the PHS in AFVD is often characterized by lateral liquefaction, unlike the altitudinal pattern seen in BVMD. Age, lesion size, or pathogenesis pathways may underlie the different PHS patterns in AFVD and BVMD.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Kai Hu, Shuai Jiang, Yuan Zhang, Xuanya Li, Xieping Gao
Summary: In this article, a joint segmentation framework is proposed for simultaneous extraction of FAZ and RV from OCTA images. Experimental results show that the proposed method outperforms state-of-the-art methods in FAZ and RV segmentations, and has fewer FLOPs and parameters. Furthermore, the method demonstrates good robustness and scalability.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Review
Biochemistry & Molecular Biology
Ana Boned-Murillo, Henar Albertos-Arranz, Maria Dolores Diaz-Barreda, Elvira Orduna-Hospital, Ana Sanchez-Cano, Antonio Ferreras, Nicolas Cuenca, Isabel Pinilla
Summary: Optical coherence tomography angiography (OCTA) is an essential tool for the diagnosis and control of diabetic patients, allowing visualization and analysis of the retinal and choroidal microvasculature, and the detection of diabetic retinopathy and other related diseases.
Article
Multidisciplinary Sciences
Anna Lee, Kyung Rim Sung, Joong Won Shin
Summary: This study found that in advanced stages of POAG eyes, vascular density loss is better than structural loss in detecting disease progression. Loss of circumpapillary and macular vessel density may help in detecting disease progression in the advanced stages of POAG.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Yan Wang, Lei Liu, Cong Li, Yuan Yang, Xue He, Meijun Jiang, Dongming Quan, Yun Ren, Hanpeng Zhao, Jianrong Jiang, Zhenchao Du, Yu Kuang, Honghua Yu, Fujun Jia, Xiaohong Yang
Summary: The study found that choroidal vessel density was lower in patients with major depressive disorder compared to healthy controls, indicating an association between decreased choroidal vessel density and MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Multidisciplinary Sciences
Woo-Hyuk Lee, Yong-Jin Na, Hyung-Bin Lim, Jae-Yun Sung, Jung-Yeul Kim, Min-Woo Lee
Summary: This study aimed to investigate the changes in the inner retinal layer and microvasculature in healthy eyes with age. The results showed that the ganglion cell-inner plexiform layer (GC-IPL) thickness and macular vessel density (VD) started to decrease in the age group above 50 years, while the GC-IPL/VD ratio significantly increased in the 60s age group. Furthermore, the GC-IPL/VD ratio was positively associated with age in subjects aged 50 years and above, indicating a more pronounced decline in VD over time compared to GC-IPL thickness.
Article
Ophthalmology
Irene Vazquez-Dominguez, Catherina H. Z. Li, Zeinab Fadaie, Lonneke Haer-Wigman, Frans P. M. Cremers, Alejandro Garanto, Carel B. Hoyng, Susanne Roosing
Summary: A study identified a complex allele in the IMPG2 gene in two unrelated individuals with vitelliform macular dystrophy, which causes splicing defects and potentially leads to the disease through a haploinsufficiency mechanism. The findings highlight the importance of using different models to functionally assess splicing defects.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Hua Zhong, Qingqing Dong, Qing Cun, Guangyu He, Yijin Tao, Keyao Song, Yunqing Lu, Qin Zhu, Xi Chen, Qin Chen
Summary: This study identified a positive correlation between peripapillary vessel density (pVD) and visual field mean sensitivity (VFMS) in healthy myopic eyes. This correlation was particularly strong in highly myopic eyes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Anna Lee, Joong Won Shin, Jin Yeoung Lee, Min Su Baek, Michael S. Kook
Summary: The purpose of this study was to investigate the relationship between optic disc hemorrhage (ODH) and the loss of parapapillary choroidal vessel density (pCVD) in open-angle glaucoma (OAG). It was found that OAG eyes with ODH had a greater severity of regional pCVD loss at the corresponding locations compared to OAG eyes without ODH.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Yuhui Ma, Huaying Hao, Jianyang Xie, Huazhu Fu, Jiong Zhang, Jianlong Yang, Zhen Wang, Jiang Liu, Yalin Zheng, Yitian Zhao
Summary: In this study, a new dataset ROSE for retinal vessel OCTA images was constructed, and a novel vessel segmentation network OCTA-Net was proposed with superior performance. Experimental results demonstrated potential advantages in studying neurodegenerative diseases through fractal dimension analysis.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Computer Science, Interdisciplinary Applications
Xiao Tan, Xinjian Chen, Qingquan Meng, Fei Shi, Dehui Xiang, Zhongyue Chen, Lingjiao Pan, Weifang Zhu
Summary: In this study, a new end-to-end transformer-based network called OCT2Former was proposed to accurately segment retinal vessels in OCTA images. The experimental results demonstrated that the proposed OCT2Former achieved competitive performance on retinal OCTA vessel segmentation tasks.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Ophthalmology
Riccardo Sacconi, Enrico Borrelli, Siva Balasubramanian, Giovanna Vella, Marco Battista, Kiran Kumar Vupparaboina, Jay Chhablani, Francesco Bandello, Giuseppe Querques
Summary: This study aimed to investigate the choroidal vascularity index (CVI) in patients with leptochoroid. The results showed that the choroidal vascular and stromal components in eyes with leptochoroid secondary to reticular pseudodrusen (RPD) and high-myopia exhibited different changes. The impairment of the vascular area in RPD eyes might contribute to the lower development of RPD in patients with high myopia.
Article
Ophthalmology
Alessandro Arrigo, Maurizio Battaglia Parodi, Emanuela Aragona, Adelaide Pina, Francesca Calcagno, Francesco Bandello, Robert E. MacLaren
Summary: The diagnostic role of the external limiting membrane (ELM) in choroideremia (CHM) was explored in this study. It was found that ELM thickness and reflectivity were correlated with outer retinal atrophy progression and choriocapillaris status. Therefore, ELM can be considered as a useful imaging biomarker in CHM.
Article
Ophthalmology
Matias Iglicki, Marina Khoury, Javier Ignacio Melamud, Lucas Donato, Adiel Barak, Diego Jose Quispe, Dinah Zur, Anat Loewenstein
Summary: This study compares the effects of subretinal and intravitreal injections in the treatment of diabetic retinopathy, and finds that subretinal injections result in better improvement in visual acuity and central subfoveal thickness, with fewer anti-VEGF injections needed during follow-up.
Editorial Material
Ophthalmology
Ashish Sharma, Mineo Kondo, Chiharu Iwahashi, Nikulaa Parachuri, Nilesh Kumar, Francesco Bandello, Anat Loewenstein, Baruch D. Kuppermann
Article
Ophthalmology
Marina Montemagni, Alessandro Arrigo, Maurizio Battaglia Parodi, Lorenzo Bianco, Alessio Antropoli, Angela Malegori, Francesco Bandello, Fausto Tranfa, Ciro Costagliola
Summary: This study aimed to describe the OCTA characteristics of a patient with Bietti crystalline dystrophy (BCD). The results showed a significant reduction in vessel density in the atrophic areas of the retina, while the apparently preserved retina exhibited normal vessel density. Additionally, the area of atrophy in the retinal pigment epithelium (RPE) was larger than the area of atrophy in the choriocapillaris (CC).
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Silvia Maestroni, Arianna Belvedere, Ilaria Vigano, Cesare Meoni, Federico Di Matteo, Daniela Gabellini, Francesco Bandello, Luisa Pierro, Gianpaolo Zerbini
Summary: There is currently no effective medical treatment for diabetic retinopathy due to limited understanding of its pathogenesis. This study suggests that the early stages of diabetic retinopathy and glaucoma may share a similar neurodegenerative process, indicating potential common mechanisms. These findings are important for further research on the treatment and pathogenesis of diabetic retinopathy.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Editorial Material
Ophthalmology
Ashish Sharma, Nilesh Kumar, Nikulaa Parachuri, Francesco Bandello, Baruch D. Kuppermann
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Maria Vittoria Cicinelli, Elisabetta L. T. De Felice, Lamberto La Franca, Alessandro Rabiolo, Alessandro Marchese, Maurizio Battaglia Parodi, Ugo Introini, Francesco Bandello
Summary: The purpose of this study was to investigate the factors associated with maximum visual improvement and the risk factors of vision loss and recurrent episodes in myopic macular neovascularization undergoing anti-vascular endothelial growth factor therapy. The results showed that patients with worse baseline visual acuity had a higher chance of achieving peak vision, while peak vision loss was mainly due to recurrent episodes. Therefore, patients at risk for recurrence should be closely monitored to prevent vision loss.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Alessio Antropoli, Alessandro Arrigo, Lorenzo Bianco, Elena Cavallari, Alessandro Berni, Filippo Casoni, Giacomo Consalez, Francesco Bandello, Ottavio Cremona, Maurizio Battaglia Parodi
Summary: The study aims to describe a continuous hyperreflective band called hyperreflective ganglion cell layer band (HGB) detected in patients with retinitis pigmentosa (RP). Retrospective analysis of OCT images showed that HGB was present in 25.3% of RP patients and associated with poorer visual function.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Editorial Material
Ophthalmology
Ashish Sharma, Anat Loewenstein, Nikulaa Parachuri, Nilesh Kumar, Alok Rasal, Francesco Bandello, Baruch D. Kuppermann
Article
Ophthalmology
Maria Vittoria Cicinelli, Claudia Gerosolima, Pierluigi Scandale, Sarah Touhami, Dominika Pohlmann, Audrey Giocanti, Amir Rosenblatt, Anat Loewenstein, Francesco Bandello, Elisabetta Miserocchi
Summary: This study aimed to investigate the clinical and SD-OCT biomarkers associated with pre- and post-injection visual acuity and the regression of macular edema (MO) following dexamethasone (DEX) implant injection in non-infectious uveitic (NIU) patients. The results showed that the integrity of the inner and outer retina was correlated with better visual response to DEX. Long-standing or recurrent MO was associated with reduced likelihood of both visual and anatomical response. Timely treatment is necessary to maximize the outcomes of MO in NIU patients.
Article
Ophthalmology
Lorenzo Bianco, Alessandro Arrigo, Alessio Antropoli, Maria Pia Manitto, Elisabetta Martina, Emanuela Aragona, Francesco Bandello, Maurizio Battaglia Parodi
Summary: This study investigated the correlation between genotypes and phenotypes in ABCA4-associated retinopathy. The results showed significant differences in disease severity among different genotypes. These findings are important for prognostication of patients and the design of future clinical trials.
JAMA OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Lorenzo Bianco, Alessandro Arrigo, Alessandro Marchese, Alessio Antropoli, Emanuela Aragona, Lamberto La Franca, Luca Mauro, Adelaide Pina, Rashid Hassan Farah, Giulia Basile, Francesco Bandello, Maurizio Battaglia Parodi
Summary: The purpose of this study was to analyze fixation location and stability in patients with best vitelliform macular dystrophy (BVMD) and investigate their association with best-corrected visual acuity (BCVA). The results showed that most eyes affected by BVMD maintained a central stable fixation, and both fixation eccentricity and stability were strongly correlated with visual acuity.
OPHTHALMOLOGY SCIENCE
(2023)
Article
Ophthalmology
Lorenzo Bianco, Alessandro Arrigo, Alessio Antropoli, Maria Pia Manitto, Elisabetta Martina, Emanuela Aragona, Francesco Bandello, Maurizio Battaglia Parodi
Summary: This study reveals significant correlations between genotypes and phenotypes in ABCA4-associated retinopathy, providing valuable insights for prognosis and guiding the design of future clinical trials.
JAMA OPHTHALMOLOGY
(2023)