Article
Critical Care Medicine
Robert D. Guglielmo, Justin C. Hotz, Patrick A. Ross, Timothy W. Deakers, Jennifer E. L. Diep, Christopher J. L. Newth, Robinder G. Khemani
Summary: HFNC therapy reduces the effort of breathing in children with bronchiolitis, but does not consistently increase end-expiratory lung volume or cause significant changes in tidal volume or transpulmonary pressure. This suggests that PEEP application is not the primary mechanism of action of HFNC in children with bronchiolitis.
Article
Oncology
Jung Sun Kim, Jeongmi Shin, Nam Hee Kim, Sun Young Lee, Shin Hye Yoo, Bhumsuk Keam, Dae Seog Heo
Summary: This study aimed to investigate the usage of high-flow nasal cannula (HFNC) in cancer patients at the end of life. The findings revealed that many patients initiated HFNC therapy during the terminal phase, highlighting the need for goal-directed use of HFNC at the end-of-life stage.
Article
Medicine, General & Internal
Zhong Ni, Yuyan Zhou, Na Tang, He Yu, Zongan Liang
Summary: The performance of HFNC devices from different manufacturers may vary in terms of humidification. The actual temperature and humidity of the delivered gas are affected by the set-flow, set-DP, and device types.
FRONTIERS IN MEDICINE
(2023)
Article
Critical Care Medicine
Douglas Slobod, Elena Spinelli, Stefania Crotti, Alfredo Lissoni, Alessandro Galazzi, Giacomo Grasselli, Tommaso Mauri
Summary: The study found that using an asymmetrical high flow nasal cannula (HFNC) interface can reduce the work of breathing and improve ventilatory efficiency in patients with mild-to-moderate hypoxemic respiratory failure. However, it does not have a significant impact on oxygenation, lung mechanics, or alveolar recruitment.
Article
Critical Care Medicine
Kazuma Nagata, Takeo Horie, Naohiko Chohnabayashi, Torahiko Jinta, Ryosuke Tsugitomi, Akira Shiraki, Fumiaki Tokioka, Toru Kadowaki, Akira Watanabe, Motonari Fukui, Takamasa Kitajima, Susumu Sato, Toru Tsuda, Nobuhito Kishimoto, Hideo Kita, Yoshihiro Mori, Masayuki Nakayama, Kenichi Takahashi, Tomomasa Tsuboi, Makoto Yoshida, Osamu Hataji, Satoshi Fuke, Michiko Kagajo, Hiroki Nishine, Hiroyasu Kobayashi, Hiroyuki Nakamura, Miyuki Okuda, Sayaka Tachibana, Shohei Takata, Hisayuki Osoreda, Kenichi Minami, Takashi Nishimura, Tadashi Ishida, Jiro Terada, Naoko Takeuchi, Yasuo Kohashi, Hiromasa Inoue, Yoko Nakagawa, Takashi Kikuchi, Keisuke Tomii
Summary: The study found that long-term use of high-flow nasal cannula can reduce the number of exacerbations in patients with chronic obstructive pulmonary disease, improving physiological parameters and quality of life.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Pediatrics
Milena S. Nascimento, Cristiane do Prado, Eduardo L. Costa, Glasiele C. Alcala, Leticia C. Correa, Felipe S. Rossi, Marcelo B. P. Amato, Celso M. Rebello
Summary: This study evaluated the effects of high-flow nasal cannula (HFNC) at different flow rates on functional residual capacity (FRC) and pulmonary ventilation distribution. The results showed that the increase in end-expiratory lung volume (EELZ) at the highest flow rates was accompanied by decreased respiratory distress scores and improved oxygenation.
PEDIATRIC PULMONOLOGY
(2022)
Article
Multidisciplinary Sciences
Kunming Cheng, Wanqing Li, Yanqiu Lu, Haiyang Wu, Jianxin Zhou
Summary: The aim of this study was to assess the effect of modified high-flow oxygen therapy on end-expiratory lung volume (EELV) and positive end-expiratory pressure (PEEP) in tracheotomized patients with normal pulmonary, acute hypoxic respiratory failure (AHRF) or chronic obstructive pulmonary disease (COPD). The results showed that as the flow rate increased, the PEEP values in all groups showed an exponential increasing trend, and the EELV also increased accordingly. In addition, the PEEP values of the modified high-flow oxygen therapies were significantly higher than those of the standard high-flow oxygen therapy.
Article
Medicine, General & Internal
Dong Liu, Teng-yu Jin, Wei Li, Li Chen, Dong Xing
Summary: The study aimed to investigate the effect of high-flow nasal cannula (HFNC) and Oxygen Nebuliser mask (ONM) on patients recovering from inhalation anesthesia. A retrospective analysis was performed on 128 patients and the results showed that compared with ONM, HFNC can shorten postoperative recovery time, reduce the incidence of agitation, and improve lung function and oxygenation state during recovery from anesthesia.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Computer Science, Interdisciplinary Applications
Lin Yang, Zhe Li, Meng Dai, Feng Fu, Knut Moeller, Yuan Gao, Zhanqi Zhao
Summary: This study aimed to predict HFNC outcomes using machine learning models based on electrical impedance tomography. After data balancing, the xgboost method showed better performance and can be considered as the ideal machine learning method for early prediction of HFNC outcomes.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Annamaria Venanzi, Paola Di Filippo, Chiara Santagata, Sabrina Di Pillo, Francesco Chiarelli, Marina Attanasi
Summary: High-flow nasal cannula (HFNC) therapy has gained interest as a valid alternative to nasal continuous positive airway pressure (nCPAP) in children with respiratory failure. Despite its wide use in clinical practice, there is a lack of guidelines to standardize the use of HFNC. This review aims to summarize the current knowledge about HFNC in children and propose a clinical practices algorithm for respiratory failure.
Article
Medicine, General & Internal
Sidharta Kusuma Manggala, Dita Aditianingsih, Eddy Harijanto
Summary: This pilot study aimed to compare the effectiveness of HFNC and conventional oxygen therapy in adult patients undergoing upper-abdominal surgery. Results showed no significant differences in clinical parameters, EIT, and ultrasound measurements between the two groups, but a significant difference in mean arterial PO2 was observed. More data is needed to draw a conclusive result.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
M. C. Jermy, C. J. T. Spence, R. Kirton, J. F. O'Donnell, N. Kabaliuk, S. Gaw, H. Hockey, Y. Jiang, Z. Zulkhairi Abidin, R. L. Dougherty, P. Rowe, A. S. Mahaliyana, A. Gibbs, S. A. Roberts
Summary: The study found that during quiet breathing, nasal high flow therapy at 60 LPM may release oral/nasal fluid particles, but in smaller quantities compared to unsupported vigorous breathing. Vigorous breathing releases significantly more oral/nasal fluid than quiet breathing, regardless of whether nasal high flow therapy is used or not.
Article
Medicine, General & Internal
Zhe Li, Zhiyun Zhang, Qian Xia, Danling Xu, Shaojie Qin, Meng Dai, Feng Fu, Yuan Gao, Zhanqi Zhao
Summary: The study aimed to predict HFNC failure based on various EIT-derived parameters but found no significant differences in ventilation distributions between the success and failure groups. Further studies are needed to predict outcomes of HFNC therapy.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Pieter Veenstra, Nic J. G. M. Veeger, Ralph J. H. Koppers, Marieke L. Duiverman, Wouter H. van Geffen
Summary: This retrospective study analyzed COPD patients treated with HFNC in a regular ward and found that sputum stasis was the most common reason for initiating HFNC treatment. Cardiac and vascular co-morbidities were associated with a smaller chance of treatment success, while in-hospital NIV treatment was associated with a higher chance of HFNC failure.
Article
Medicine, General & Internal
Amy H. Attaway, Jihane Faress, Frank Jacono, Srinivasan Dasarathy
Summary: The study revealed that increasing oxygen fraction without adjusting flow rate may exacerbate hypercapnia in COPD patients. Therefore, careful titration of oxygen therapy is essential, especially in COPD patients with baseline hypercapnia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Gustavo A. Plotnikow, Dario Villalba, Emiliano Gogniat, Corina Quiroga, Eliana Perez Calvo, Jose Luis Scapellato
Article
Critical Care Medicine
Pablo O. Rodriguez, Norberto Tiribelli, Sebastian Fredes, Emiliano Gogniat, Gustavo Plotnikow, Ignacio Fernandez Ceballos, Romina Pratto, Alejandro Raimondi, Maria Guaymas, Santiago Ilutovich, Eduardo San Roman, Matias Madorno, Patricio Maskin, Laurent Brochard, Mariano Setten
Summary: The study found that approximately 50% of ARDS patients receiving assist-control ventilation exhibited reverse triggering on the first day of mechanical ventilation, but the majority of events were not associated with breath stacking. Reverse triggering may be associated with low tidal volume and opiate doses.
Article
Respiratory System
Tai Pham, Antonio Pesenti, Giacomo Bellani, Gordon Rubenfeld, Eddy Fan, Guillermo Bugedo, Jose Angel Lorente, Antero do Vale Fernandes, Frank Van Haren, Alejandro Bruhn, Fernando Rios, Andres Esteban, Luciano Gattinoni, Anders Larsson, Daniel F. McAuley, Marco Ranieri, B. Taylor Thompson, Hermann Wrigge, Laurent J. Brochard, John G. Laffey
Summary: For patients with acute hypoxaemic respiratory failure requiring mechanical ventilation, the global hospital mortality rate is 38.6%. Survival depends on the degree of lung involvement rather than meeting ARDS criteria.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Critical Care Medicine
Elisa Estenssoro, Cecilia Loudet, Fernando G. Rios, Vanina S. Kanoore Edul, Gustavo Plotnikow, Macarena Andrian, Ignacio Romero, Marco Bezzi, Carla Groer, Cristina Orlandi, Paolo N. Rubatto Birri, Maria F. Valenti, Eleonora Cunto, Maria G. Saenz, Norberto Tiribelli, Vanina Aphalo, Rosa Reina
Summary: The study investigated invasively ventilated COVID-19 patients in Argentina, where lung-protective ventilation was widely used but mortality remained high. Predictors of mortality in this study were largely consistent with findings from high-income countries.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Critical Care Medicine
Mauro Andreu, Matias Bertozzi, Marco Bezzi, Silvina Borello, Daniela Castro, Victoria Di Giorgio, Mariana Aguirre
Summary: This study aimed to compare the positive-pressure and traditional orotracheal extubation techniques in critically ill adult patients, and determine their effects on major postextubation complications within 60 minutes. The results showed no statistically significant differences between the two techniques. The findings support the literature that positive-pressure extubation is a safe procedure, and both techniques can be used during extubation in critically ill adult patients.
Article
Public, Environmental & Occupational Health
Luigi Pisani, Anna Geke Algera, Ary Serpa Neto, Luciano Azevedo, Tai Pham, Frederique Paulus, Marcelo Gama de Abreu, Paolo Pelosi, Arjen M. Dondorp, Giacomo Bellani, John G. Laffey, Marcus J. Schultz
Summary: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in middle income countries (MICs) than in high-income countries (HICs), with a strong association with country-level economic status.
LANCET GLOBAL HEALTH
(2022)
Article
Critical Care Medicine
Manoj Maddali, Matthew Churpek, Tai Pham, Emanuele Rezoagli, Hanjing Zhuo, Wendi Zhao, June He, Kevin L. Delucchi, Chunxue Wang, Nancy Wickersham, J. Brennan McNeil, Alejandra Jauregui, Serena Ke, Kathryn Vessel, Antonio Gomez, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Aartik Sarma, Aleksandra Leligdowicz, Kathleen D. Liu, Michael A. Matthay, Lorraine B. Ware, John G. Laffey, Giacomo Bellani, Carolyn S. Calfee, Pratik Sinha
Summary: Clinical classifier models based on machine learning can accurately assign ARDS subphenotypes, providing valuable prognostic information for patients and potentially guiding personalized treatment strategies in clinical practice.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Critical Care Medicine
Adrian Gallardo, Adrian P. Devoli, German E. M. Bustillo Arevalo, Santiago N. Saavedra, Roque S. Moracci, Romina A. Pratto, Gustavo A. Plotnikow, Jose L. Leone, Carolina M. Travetto
Summary: This study evaluated the impact of high-flow nasal cannula (HFNC) compared to standard oxygen therapy on patients with acute hypoxemic respiratory failure (AHRF) caused by COVID-19. The results showed that HFNC therapy was not an independent predictor of endotracheal intubation frequency after adjusting for confounders.
Article
Critical Care Medicine
Gustavo A. Plotnikow, Dario S. Villalba, Eliana Perez Calvo, Corina Quiroga, Emiliano Navarro
Summary: The performance of heated humidifiers in delivering absolute humidity during high-flow oxygen therapy depends on the combination of devices, circuits, and programmed flow rates. Some heated humidifiers achieve high absolute humidity values in the invasive mode. However, some devices exhibit inadequate humidification capabilities.
Article
Critical Care Medicine
Elisa Estenssoro, Cecilia Loudet, Arnaldo Dubin, Vanina S. Kanoore Edul, Gustavo Plotnikow, Macarena Andrian, Ignacio Romero, Judith Sagardia, Marco Bezzi, Veronica Mandich, Carla Groer, Sebastian Torres, Cristina Orlandi, Paolo N. Rubatto Birri, Maria F. Valenti, Eleonora Cunto, Maria G. Saenz, Norberto Tiribelli, Vanina Aphalo, Lisandro Bettini, Fernando G. Rios, Rosa Reina
Summary: The study aimed to identify determinants of oxygenation in COVID-19 ARDS patients and analyze their characteristics according to Berlin definition categories. The results showed that factors such as obesity, preexistent respiratory disease, D-dimer levels, ventilatory ratio, and PEEP levels were associated with changes in oxygenation levels.
JOURNAL OF CRITICAL CARE
(2022)
Article
Medicine, General & Internal
Gabriel Musso, Cecilia Gonzalez, Maria Celeste Gomez, Gabriel Appendino, Lucio Clemente, Analia Abarca, Luciano Friscione, Gustavo A. Plotnikow, Florencia Montagner, Ornela Abbondanzieri, Lucas Id Betan, Faustino Braconi, Azul Bianco, Paloma Guerrero, Yamila Garrido, Hernan Carranza, Luciano Berloni, Carlos Lovesio, Martin Manago
Summary: This study described the characteristics and ventilatory variables of COVID-19 patients, comparing differences between the two waves in Argentina. Independent predictors of ICU mortality included age, Delta P, and the second wave.
MEDICINA-BUENOS AIRES
(2022)
Article
Medicine, General & Internal
Elisa Estenssoro, Gustavo Plotnikow, Cecilia Loudet, Fernando G. Rios, Vanina S. Kanoore Edul, Macarena Andrian, Ignacio Romero, Judith Sagardia, Marco Bezzi, Veronica Mandich, Carla Groer, Sebastian Torres, Cristina Orlandi, Paolo Nahuel Rubatto Birri, Maria Florencia Valenti, Eleonora Cunto, Maria Gabriela Saenz, Norberto Tiribelli, Vanina Aphalo, Lisandro Bettini, Rosa Reina, Arnaldo Dubin
Summary: During the SARS-CoV-2 pandemic, the Argentine Society of Intensive Care (SATI) conducted a study to characterize the aspects of intensive care units (ICUs), finding an increase in critical care beds, staff, and availability of essential supplies and ventilators. More than half of COVID-19 patients required mechanical ventilation.
MEDICINA-BUENOS AIRES
(2022)
Letter
Critical Care Medicine
D. Gilgado, E. Perez Calvo, J. Perez, J. Dorado, G. Cardoso, C. Quiroga, J. Scapellato, G. Plotnikow, M. Accoce
MEDICINA INTENSIVA
(2021)
Article
Critical Care Medicine
Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tai Pham, John G. Laffey, Giacomo Bellani
Summary: The study revealed a significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors.
Article
Critical Care Medicine
Fabiana Madotto, Emanuele Rezoagli, Tai Pham, Marcello Schmidt, Bairbre McNicholas, Alessandro Protti, Rakshit Panwar, Giacomo Bellani, Eddy Fan, Frank van Haren, Laurent Brochard, John G. Laffey