Article
Environmental Sciences
Nolwenn Adam, Marie-Amelie Lachayze, Caroline Parmentier, Helene Hardin-Pouzet, Sakina Mhaouty-Kodja
Summary: This study examined the effects of exposure to DEHP, an organic pollutant, on maternal behavior in mice. The findings suggest that exposure to DEHP can alter maternal behavior, possibly through neuroendocrine pathways involving oxytocin and estrogen.
ENVIRONMENTAL POLLUTION
(2022)
Article
Toxicology
Davidson Peruci Moreira, Yves Moreira Ribeiro, Camila Stephanie Ferreira, Samyra Maria dos Santos Nassif Lacerda, Elizete Rizzo
Summary: This study aimed to investigate the effects of chronic exposure to environmentally relevant ACE concentrations on multiple reproductive parameters in zebrafish. The results showed that ACE impaired the reproductive performance of zebrafish, including a decrease in egg and sperm quantity and quality, as well as an imbalance of sex steroids and prostaglandin E-2 levels. These findings indicate the impact of ACE on the reproductive ability of aquatic species.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nataliya Yaglova, Dibakhan A. Tsomartova, Sergey S. Obernikhin, Valentin V. Yaglov, Svetlana Nazimova, Elina S. Tsomartova, Elizaveta Chereshneva, Marina Y. Ivanova, Tatiana A. Lomanovskaya
Summary: DDT exposure during prenatal and postnatal development results in lower testosterone production and increased estradiol levels in male rats after maturation, while postnatal exposure leads to accelerated growth of gonads and higher testosterone production during puberty. Both types of exposure affect sex steroid hormone production in an age-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yuyang Wang, Hong-Sheng Wang
Summary: The study found that the impact of BPA on the pulsing rate of L. variegatus is likely mediated by an estrogenic mechanism instead of general toxicity. L. variegatus exhibits exceptionally high sensitivity to certain estrogens, making it a possible tool for estrogenic EDC screening.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaohui Liu, Keitaro Suyama, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi
Summary: The study reports the dual action of bisphenol compounds on ER alpha and ER beta receptors, with the bisphenol E analogs exhibiting enhanced agonist/antagonist activities due to an electrostatic halogen bond. Bisphenol C (BPC) is found to be a bifunctional ER alpha-agonist and ER beta-antagonist, with high ER alpha activity and inhibitory activity against ER beta. The intensified receptor interaction of BPC is attributed to the presence of an n-pi-pi-n conjugation system mediated through the >C = CCl2 double bond.
Article
Marine & Freshwater Biology
Shireen H. Jackman, Ellis P. Evans, Haley N. Kuecks-Winger, Lorissa M. Corrie, Jacob J. Imbery, Rachel C. Miliano, Bonnie J. Robert, Vanessa C. Thompson, Anita A. Thambirajah, Mary L. Lesperance, Gregory G. Pyle, Graham van Aggelen, Caren C. Helbing
Summary: Thyroid hormones play an important role in vertebrate development, especially during the metamorphosis of tadpoles into frogs. Comparing transcriptomic profiles, this study found distinct differences between the responses elicited by estrogen and thyroid hormones, as well as tissue-dependent variations in the responses to different thyroid hormones. These findings are significant for understanding the effects of hormone-active agents and the mechanisms of endocrine disrupting chemicals.
AQUATIC TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wagner Antonio Tamagno, Carla Alves, Ana Paula Vanin, Denise Bilibio, Amanda Carolina Cole Varela, Mateus Timbola Mozzato, Leonardo Jose Gil Barcellos
Summary: Endocrine disruptors (EDs) can alter the homeostasis of organisms even at low concentrations through biochemical and physiological pathways. This study evaluated the dietary transfer of 17 alpha-ethinylestradiol (EE2) in adult zebrafish and its effects on behavior and biochemical markers. The results showed that EE2 had detrimental effects on the behavior of fish and could potentially harm the environment and other animals, including humans.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Michael Douglas S. Monteiro, Mercia V. S. Sant'Anna, Jose C. Santos, Jose F. Macedo, Anderson A. C. Alves, Jonatas de Oliveira S. Silva, Iara F. Gimenez, Eliana Midori Sussuchi
Summary: This study reports the development of a modified electrode with reduced graphene oxide for the determination of 17 alpha-ethinylestradiol. The electrode was characterized using various techniques and showed good analytical performance. The method can be used for the identification and quantification of 17 alpha-ethinylestradiol in different matrices.
Review
Chemistry, Physical
Elisabetta Loffredo
Summary: This article discusses the modern and sustainable approach of utilizing biowaste for environmental protection, including waste conversion to bioenergy and the application of materials such as biochar for adsorbing environmental estrogens. These materials are attracting attention due to their low cost, improving performance, and contribution to addressing other emergencies.
Article
Environmental Sciences
Elizabeth Goya-Jorge, Mazia Amber, Rafael Gozalbes, Lisa Connolly, Stephen J. Barigye
Summary: This study used computational and in vitro methods to model estrogenicity and prioritize ESR agonist compounds using QSAR models. Mechanistic interpretations of molecular descriptors and validation through in vitro experiments demonstrated the value of QSARs in predicting and prioritizing agonist compounds.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Lisa C. Ohman, Robin F. Krimm
Summary: Taste buds are specialized collections of taste-transducing cells that detect subsets of chemical stimuli in the oral cavity. Due to the continuous turnover of these cells, the taste-bud environment is complex and dynamic, requiring detailed analyses of cell types, locations, and relationships between them.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Pathology
Brendan L. Rooney, Brian P. Rooney, Vinona Muralidaran, Weisheng Wang, Priscilla A. Furth
Summary: This study developed a readily accessible program for digital assessment of mammary gland whole mount density across a range of mammary gland morphologies. The study found that mammographic density is associated with increased breast cancer risk.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Cell Biology
Ellen Cristina Rivas Leonel, Thalles Fernando Rocha Ruiz, Carolina Marques Bedolo, Silvana Gisele Pegorin Campos, Sebastiao Roberto Taboga
Summary: The study evaluated inflammatory responses of the mammary gland and prostate to BPA and estradiol exposure, finding an increase in phospho-STAT3 positive cells and macrophages in the prostate of animals exposed to BPA, while the mammary gland did not show differences in inflammatory markers. The findings suggest that exposure to endocrine disruptors during the perinatal period leads to different inflammatory responses in reproductive organs, with the prostate being more susceptible to inflammatory mechanisms.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Chemistry, Applied
Karma C. Fussell, Maricel Marin-Kuan, Emma Debon, Bastien Gentili, Delphine Morin-Rivron, Laure Poquet, Patrick Serrant, Flavia Badoud, Thomas Bessaire, Nicolas Christinat, Marion Ernest, Alexandre Felix, Helia Latado, Gina Montoya Parra, Gabriele Scholz, Thomas Stroheker, Benoit Schilter
Summary: The study found that there are differences in activity levels when using different methods in effect-based assays of food products, indicating that the current food testing data may not be suitable for consumer advice or food decision-making yet.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2021)
Review
Toxicology
Christopher J. Borgert
Summary: Styrene is not considered an endocrine disruptor based on a rigorous evaluation of its potential to disrupt EATS pathways. The responses to styrene were inconsistent with patterns expected for chemicals and hormones known to disrupt endocrine function. Further endocrine screening for styrene would not provide useful information and would be unjustified from an animal welfare perspective.
CRITICAL REVIEWS IN TOXICOLOGY
(2023)
Review
Endocrinology & Metabolism
Frederick S. Vom Saal, Laura N. Vandenberg
Summary: Studies have shown adverse effects of low doses of BPA on animals, but regulatory agencies continue to assert that BPA exposures are safe.
Article
Environmental Sciences
Jing Zhang, Zhenyang Yu, Jiaying Shen, Laura N. Vandenberg, Daqiang Yin
Summary: The study shows that exposure to erythromycin can affect lipid metabolism, body weight, and circadian rhythm in Drosophila melanogaster, with differences observed between generations depending on sex, rhythm, and exposure generation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Endocrinology & Metabolism
Joshua P. Mogus, Charlotte D. LaPlante, Ruby Bansal, Klara Matouskova, Benjamin R. Schneider, Elizabeth Daniele, Shannon J. Silva, Mary J. Hagen, Karen A. Dunphy, D. Joseph Jerry, Sallie S. Schneider, Laura N. Vandenberg
Summary: The study found that propylparaben may interfere with the protective effects of parity on the mouse mammary gland, leading to long-term alterations in mammary gland structure. Further research is needed to determine if propylparaben exposure negates the protective effects of pregnancy on mammary cancer development.
Article
Environmental Sciences
Rebecca F. Goldberg, Laura N. Vandenberg
Summary: The research identified 28 unique tactics used for manufacturing doubt across five different industries and organizations, with five tactics used by all. The intended audience and logical fallacies play a role in the effectiveness of these strategies.
ENVIRONMENTAL HEALTH
(2021)
Review
Pharmacology & Pharmacy
Akhgar Ghassabian, Laura Vandenberg, Kurunthachalam Kannan, Leonardo Trasande
Summary: This article discusses the unique vulnerability of children to endocrine-disrupting chemicals (EDCs) and the programming effects of EDCs on neuronal, metabolic, immune, endocrine, reproductive, and renal systems. By dispelling myths and providing a list of actions to reduce exposure and harm, it aims to address the health effects of EDCs on child health.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Review
Environmental Sciences
Klara Matouskova, Laura N. Vandenberg
Summary: This study aims to develop a set of ethical principles to guide decision-making in environmental health and apply these principles to the specific chemical oxybenzone. We propose six ethical principles, including sustainability, beneficence, non-maleficence, justice, community, and precautionary substitution. The case of oxybenzone demonstrates the complexity and importance of decision-making to address the limits of the biosphere's regenerative rates. Both ethical and practical considerations should be taken into account in decisions regarding the widespread use of synthetic compounds.
ENVIRONMENTAL HEALTH
(2022)
Review
Endocrinology & Metabolism
Laura N. Vandenberg, Katherine E. Pelch
Summary: Background: Endocrine disrupting chemicals (EDCs) are found in various consumer goods and pose risks to human health. This review focuses on the evaluation of EDCs in risk assessments, with a particular emphasis on Bisphenol A (BPA). The use of systematic review methodologies is proposed to improve the assessment process and ensure transparent decision-making.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Article
Reproductive Biology
Alina M. Hamilton, Linnea T. Olsson, Bentley R. Midkiff, Elena Morozova, Yanrong Su, Sandra Z. Haslam, Laura N. Vandenberg, Sallie S. Schneider, Julia Santucci-Pereira, D. Joseph Jerry, Melissa A. Troester, Richard C. Schwartz
Summary: This study evaluated mammary gland density in mice and rats using digital methods and found that they can detect changes in density caused by hormonal stimuli, dietary fat, and exposure to environmental chemicals. This digital analysis provides a highly reproducible means of comparing histological density across different experiments, systems, and laboratories.
REPRODUCTIVE TOXICOLOGY
(2022)
Review
Endocrinology & Metabolism
Fadil M. Hannan, Taha Elajnaf, Laura N. Vandenberg, Stephen H. Kennedy, Rajesh V. Thakker
Summary: Lactation is crucial for the health of both infants and mothers, and is regulated by reproductive and metabolic hormones. The development of mammary glands and synthesis of milk are closely related to hormonal functions, which are stimulated by infant suckling. After weaning, there is a large-scale cell loss in the glands leading to involution. The hormonal composition of human milk also has effects on infant health and development. Additionally, endocrine and metabolic diseases, labor interventions, and exposure to endocrine-disrupting chemicals can cause lactation insufficiency.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Klara Matouskova, Gillian K. Szabo, Jessica Daum, Suzanne E. Fenton, Sofie Christiansen, Ana M. Soto, Jennifer E. Kay, Bethsaida Cardona, Laura N. Vandenberg
Summary: Research suggests that exposure to hormonally active chemicals during sensitive windows of development can impact mammary gland development, function, and disease risk. Stronger links between environmental pollutants and breast health disruptions continue to be found in human populations. This article provides technical guidance on collecting and evaluating the mammary gland in mice and rats, including methods for sample collection and analysis. The authors argue that the mammary gland should be considered in chemical safety assessments and recommend improved measures for evaluating mammary gland outcomes.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Environmental Sciences
Tracey J. Woodruff, Swati D. G. Rayasam, Daniel A. Axelrad, Patricia D. Koman, Nicholas Chartres, Deborah H. Bennett, Linda S. Birnbaum, Phil Brown, Courtney C. Carignan, Courtney Cooper, Carl F. Cranor, Miriam L. Diamond, Shari Franjevic, Eve C. Gartner, Dale Hattis, Russ Hauser, Wendy Heiger-Bernays, Rashmi Joglekar, Juleen Lam, Jonathan I. Levy, Patrick M. MacRoy, Maricel V. Maffini, Emily C. Marquez, Rachel Morello-Frosch, Keeve E. Nachman, Greylin H. Nielsen, Catherine Oksas, Dimitri Panagopoulos Abrahamsson, Heather B. Patisaul, Sharyle Patton, Joshua F. Robinson, Kathryn M. Rodgers, Mark S. Rossi, Ruthann A. Rudel, Jennifer B. Sass, Sheela Sathyanarayana, Ted Schettler, Rachel M. Shaffer, Bhavna Shamasunder, Peggy M. Shepard, Kristin Shrader-Frechette, Gina M. Solomon, Wilma A. Subra, Laura N. Vandenberg, Julia R. Varshavsky, Roberta F. White, Ken Zarker, Lauren Zeise
Summary: The manufacture and production of industrial chemicals continues to increase, leading to widespread population exposures and resultant health impacts. Low-wealth communities and communities of color often bear disproportionate burdens of exposure and impact. Multiple authoritative bodies and scientific consensus groups have called for actions to prevent harmful exposures via improved policy approaches. We developed consensus recommendations for health-protective, scientific approaches to reduce harmful chemical exposures, which can be applied to current US policies governing industrial chemicals and environmental pollutants.
ENVIRONMENTAL HEALTH
(2023)
Review
Environmental Sciences
Laura N. Vandenberg, Swati D. G. Rayasam, Daniel A. Axelrad, Deborah H. Bennett, Phil Brown, Courtney C. Carignan, Nicholas Chartres, Miriam L. Diamond, Rashmi Joglekar, Bhavna Shamasunder, Kristin Shrader-Frechette, Wilma A. Subra, Ken Zarker, Tracey J. Woodruff
Summary: Understanding and quantifying human exposures to environmental chemicals is crucial for public health protection. Inadequate exposure assessments conducted by polluting industries or regulatory agencies have led to the disregard of exposure concerns raised by communities and the underestimation of risks, allowing pollutants to go unregulated. Researchers, risk assessors, and policy makers need to address the issues affecting exposure assessments and utilize exposure data to make informed decisions for health protection.
ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Gabriela Vieyra, Susan E. Hankinson, Youssef Oulhote, Laura Vandenberg, Lesley Tinker, JoAnn Mason, Aladdin H. Shadyab, Robert Wallace, Chrisa Arcan, J. C. Chen, Katherine W. Reeves
Summary: This study evaluated the associations between dietary patterns and urinary phthalate biomarkers. It found that postmenopausal women with higher alignment to DASH and aMed dietary patterns had lower concentrations of certain phthalate biomarkers in their urine, while an inflammatory diet pattern was associated with higher phthalate biomarker concentrations.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Jennifer E. Kay, Bethsaida Cardona, Ruthann A. Rudel, Laura N. Vandenberg, Ana M. Soto, Sofie Christiansen, Linda S. Birnbaum, Suzanne E. Fenton
Summary: Population studies have shown worrying trends in breast development, breastfeeding difficulties, and increased breast cancer rates in young women. Chemical exposures have been linked to these outcomes, with endocrine-disrupting chemicals often disrupting hormonal regulation. Current toxicological approaches are inadequate in detecting these effects, hindering our ability to identify harmful exposures to the breast and prevent them.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2022)
Review
Endocrinology & Metabolism
Laura N. Vandenberg
Summary: Experts have concluded that EDCs have significant impacts on the health of humans and wildlife, calling for immediate action to protect current and future generations from harm.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2021)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
