期刊
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
卷 16, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s12958-018-0358-6
关键词
Seminal plasma; Exosomes; Prostasomes; Epididymosomes; Cytokines; Female reproductive tract; Male infertility; Proteomics; Assisted reproductive technologies
资金
- American Center for Reproductive Medicine, Cleveland Clinic, Ohio, USA
- Council of Scientific and Industrial Research [09/1036/0005/2016 EMR-I]
- Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD/109284/2015]
- Fulbright Program [E0585639]
Background: The 'omics' approach for a noninvasive diagnosis of male reproductive system disorders has gained momentum during the last decade, particularly from a screening and prognosis point of view. Due to the rapid development in assisted reproductive technologies (ART) over the years, the major focus of proteomic studies has been around the ejaculated spermatozoa. Although seminal plasma is not a requirement for ART, the question arose whether the role of seminal plasma is merely to transport spermatozoa. Main body: Seminal plasma (SP) contains a large diversity of proteins that are essential not only for sperm transport, but also for sperm protection and maturation. Most of the proteins bind to sperm surface through exosomes (epididymosomes and prostasomes), modulating sperm function, interaction with the female reproductive tract and finally fertilization. This review focuses on the state-of-art discoveries regarding SP proteome and its role in fertilization. Conclusion: Tissue-specific proteins in the SP have emerged as fundamental contributors for protein biomarker discovery. This is important for a noninvasive diagnosis of male infertility and development of new therapeutic approaches. Moreover, ART success rates may be improved by taking into account the critical role of seminal proteome in fertilization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据