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Food and feed safety of DAS-444epmty set6-6 herbicide-tolerant soybean

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REGULATORY TOXICOLOGY AND PHARMACOLOGY
卷 94, 期 -, 页码 70-74

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ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yrtph.2018.01.016

关键词

DAs-444epmty set6-6; Soybean; AAD-12; Safety; Food; Feed; Risk

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DAS-444empty set6-6 soybean was genetically engineered (GE) to withstand applications of three different herbicides. Tolerance to glufosinate and glyphosate is achieved through expression of the phosphinothricin acetyltransferase (PAT) and double-mutated maize 5-enolpyruvyl shikimate-3-phosphate synthase (2mEPSPS) enzymes, respectively. These proteins are expressed in currently commercialized crops and represent no novel risk. Tolerance to 2,4-dichlorophenoxyacetic acid (2,4-D) is achieved through expression of the aryloxyalkanoate dioxygenase 12 (AAD-12) enzyme, which is novel in crops. The safety of the AAD-12 protein and DAS-444empty set6-6 event was assessed for food and feed safety based on the weight of evidence and found to be as safe as non-GE soybean.

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