Article
Cell & Tissue Engineering
Yusheng Cai, Si Wang, Jing Qu, Juan Carlos Izpisua Belmonte, Guang-Hui Liu
Summary: Stem cell therapies offer promising approaches for treating various diseases by addressing stem cell exhaustion and dysfunction. Recent advances in understanding the mechanisms of stem cell regeneration and rejuvenation strategies utilizing intrinsic and extrinsic factors may pave the way for interventions to delay aging and treat age-associated diseases.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Review
Cell Biology
Mingjia Cheng, Weihao Yuan, Alireza Moshaverinia, Bo Yu
Summary: Advanced age is a shared risk factor for chronic skeletal diseases. The senescence of mesenchymal stem cells (MSCs) exacerbates inflammatory microenvironment and disrupts bone remodeling, contributing to age-related bone diseases. Understanding the molecular and epigenetic mechanisms of MSC senescence, such as oxidative stress and mitochondrial dysfunction, could present rejuvenation strategies for skeletal aging restoration.
Article
Peripheral Vascular Disease
Shota Shimizu, Tomohiro Iba, Hisamichi Naito, Fitriana Nur Rahmawati, Hirotaka Konishi, Weizhen Jia, Fumitaka Muramatsu, Nobuyuki Takakura
Summary: This study found that the number of tissue-resident vascular endothelial stem cells (VESCs) was lower in aged mice and their potential to differentiate into endothelial cells was impaired. The study also discovered that inflammatory signaling was more activated in aged mice, suggesting the possible involvement of age-associated inflammation in the functional decline of VESCs.
Review
Endocrinology & Metabolism
Emma Laporte, Annelies Vennekens, Hugo Vankelecom
Summary: The pituitary gland has the ability to dynamically adapt its cell composition to changing hormonal needs throughout life. Different hormonal cell populations expand during growth and development, and decline in function is associated with aging. The involvement and phenotype of pituitary stem cells in pituitary remodeling events remain largely unknown, presenting unanswered questions in pituitary research.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Korin Sahinyan, Felicia Lazure, Darren M. Blackburn, Vahab D. Soleimani
Summary: This review discusses the factors and effects of declining numbers and regenerative potential of muscle stem cells (MuSCs) during aging, and emphasizes the importance of understanding these changes for developing effective therapies for age-related muscle defects.
Review
Biochemistry & Molecular Biology
Matthias Mietsch, Rabea Hinkel
Summary: With the prevalence of cardiovascular diseases, there is an urgent need for new treatment strategies. While stem cell based approaches have shown promise in improving cardiac functions, recent research has highlighted the potential importance of mitochondria in these treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Multidisciplinary Sciences
David J. J. Glass
Summary: Senescent cells in skeletal muscle promote inflammation and hinder regeneration, potentially causing harmful changes in aged muscle.
Review
Biochemistry & Molecular Biology
Jaba Tkemaladze
Summary: During asymmetric stem cell divisions, daughter cells selectively preserve mother (old) centrioles, which are more susceptible to destruction than other cell structures. This may be the main cause of cell aging.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Cell Biology
Estel Ramos-Marques, Laura Garcia-Mendivil, Maria Perez-Zabalza, Hazel Santander-Badules, Sabarathinam Srinivasan, Juan Carlos Oliveros, Rafael Torres-Perez, Alberto Cebollada, Jose Maria Vallejo-Gil, Pedro Carlos Fresneda-Roldan, Javier Fananas-Mastral, Manuel Vazquez-Sancho, Marta Matamala-Adell, Juan Fernando Sorribas-Berjon, Javier Andre Bellido-Morales, Francisco Javier Mancebon-Sierra, Alexander Sebastian Vaca-Nunez, Carlos Ballester-Cuenca, Manuel Jimenez-Navarro, Jose Manuel Villaescusa, Elisa Garrido-Huescar, Margarita Segovia-Roldan, Aida Olivan-Viguera, Carlos Gomez-Gonzalez, Gorka Muniz, Emiliano Diez, Laura Ordovas, Esther Pueyo
Summary: This study characterized the transcriptome dynamics of aging left ventricle (LV) in humans, demonstrating the higher sensitivity of biological age (BA) over chronological age (CA) in explaining cardiac dysfunction. The study identified BA-related microRNAs and revealed depleted cardiac-specific processes undetected by CA. Furthermore, a microRNA-gene regulatory network related to cardiac processes was described, showing novel insights into human LV biological aging.
Review
Endocrinology & Metabolism
Lingjun Rong, Lixia Zhang, Zaigang Yang, Lijun Xu
Summary: Bone-related diseases are a major health burden, and stem cell therapy has emerged as an effective strategy for tissue repair. However, the identity and definition of skeletal stem cells remain controversial. Recent progress in purifying skeletal stem cells and understanding their role in bone development and repair, as well as the impact of aging, has been made through advances in technology.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Huihui He, Yuan Yuan, Yunhong Wu, Jingyi Lu, Xiaofu Yang, Kejie Lu, An Liu, Zelin Cao, Miao Sun, Mengfei Yu, Huiming Wang
Summary: The integration of metal-organic frameworks exoskeletons with bone marrow stem cells (BMSCs) improves cell survival and enhances cardiac repair. The partially coated cells are able to withstand detrimental environmental conditions and promote cell adhesion. The interaction between exoskeletons and cell surface receptors leads to altered gene expression and enhanced biological functions.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Shengqiang Li, Zhen Lei, Xiaomei Yang, Meng Zhao, Yonghao Hou, Di Wang, Shuhai Tang, Jingxin Li, Jingui Yu
Summary: The study found that propofol can protect the myocardium from I/R injury by inhibiting ferroptosis and the AKT/p53 signaling pathway. This research provides a theoretical basis for understanding the prevention and treatment of myocardial ischemia/reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Anne Marie Josephson, Kevin Leclerc, Lindsey H. Remark, Emma Muinos Lopez, Philipp Leucht
Summary: The decline in regenerative potential of aging tissues is attributed to changes in tissue-specific stem cells and their niches, particularly in bone where aged skeletal stem/progenitor cell dysfunction is related to inflamm-aging. By using a mouse model of parabiosis, it was demonstrated that exposure to inflammatory secretome can lead to a phenotype similar to aging in skeletal stem cells.
Article
Biology
Diptiman Chanda, Mohammad Rehan, Samuel R. Smith, Kevin G. Dsouza, Yong Wang, Karen Bernard, Deepali Kurundkar, Vinayak Memula, Kyoko Kojima, James A. Mobley, Gloria A. Benavides, Victor Darley-Usmar, Young-iL Kim, Jaroslaw W. Zmijewski, Jessy S. Deshane, Stijn De Langhe, Victor J. Thannickal
Summary: This study revealed the impact of cellular aging on the ability of L-MSC and AEC2s cells to form three-dimensional organoids, and found that reducing Nox4 activity may reverse critical effects of cellular aging.
Review
Cell Biology
Vineeta Sharma, Sanat Kumar Dash, Kavitha Govarthanan, Rekha Gahtori, Nidhi Negi, Mahmood Barani, Richa Tomar, Sudip Chakraborty, Santosh Mathapati, Dillip Kumar Bishi, Poonam Negi, Kamal Dua, Sachin Kumar Singh, Rohit Gundamaraju, Abhijit Dey, Janne Ruokolainen, Vijay Kumar Thakur, Kavindra Kumar Kesari, Niraj Kumar Jha, Piyush Kumar Gupta, Shreesh Ojha
Summary: Myocardium Infarction (MI) is a leading cause of death worldwide, with pharmacological interventions not being the forefront in improving outcomes. Stem cell-based tissue engineering approaches have shown promise in regenerating the infarcted myocardium. Research using microfluidic devices has provided insights into the pathophysiology of MI, aiding in the differentiation of stem cells and engineering of scaffolds mimicking native cardiac conditions. Delivery of stem cell-loaded engineered scaffolds to the infarction site remains a challenge for future clinical translation.
