Article
Medicine, General & Internal
Deborah Schrag, Qian Shi, Martin R. Weiser, Marc J. Gollub, Leonard B. Saltz, Benjamin L. Musher, Joel Goldberg, Tareq Al Baghdadi, Karyn A. Goodman, Robert R. McWilliams, Jeffrey M. Farma, Thomas J. George, Hagen F. Kennecke, Ardaman Shergill, Michael Montemurro, Garth D. Nelson, Brian Colgrove, Vallerie Gordon, Alan P. Venook, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Amylou C. Dueck, Ethan Basch, George J. Chang, Harvey J. Mamon
Summary: Preoperative FOLFOX chemotherapy is as effective as preoperative chemoradiotherapy for locally advanced rectal cancer eligible for sphincter-sparing surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaofeng Jiang, Hengyu Zhao, Oliver Lester Saldanha, Sven Nebelung, Christiane Kuhl, Iakovos Amygdalos, Sven Arke Lang, Xiaojian Wu, Xiaochun Meng, Daniel Truhn, Jakob Nikolas Kather, Jia Ke
Summary: A deep learning model based on preoperative MRI scans was developed and validated to predict survival in patients with rectal cancer.
Article
Medicine, General & Internal
Re- Chin, Ebunoluwa E. Otegbeye, Kylie H. Kang, Su-Hsin Chang, Scott McHenry, Amit Roy, William C. Chapman, Lauren E. Henke, Shahed N. Badiyan, Katrina Pedersen, Benjamin R. Tan, Sean C. Glasgow, Matthew G. Mutch, Pamela P. Samson, Hyun Kim
Summary: This study compared the cost-effectiveness of SCRT-TNT and LCCRT in the treatment of patients with locally advanced rectal cancer. The results showed that SCRT-TNT had lower costs and improved quality-adjusted life years (QALYs) compared to conventional LCCRT.
Article
Cardiac & Cardiovascular Systems
Lei Xu, Xian-kai Chen, Hou-nai Xie, Zhen Wang, Jian-jun Qin, Yin Li
Summary: The optimal treatment strategy for resectable cervical esophageal cancer varies according to disease stage. Surgery alone improves long-term survival for patients with localized disease, while surgery-based multimodal therapy increases survival rate for patients with regional disease.
ANNALS OF THORACIC SURGERY
(2022)
Article
Multidisciplinary Sciences
Amal Rayan, Ahmed Soliman
Summary: The study aims to provide more detailed prognostic models for early prediction of local recurrences and local recurrence free survival in patients with locally advanced rectal carcinomas treated with neoadjuvant chemoradiation. Different radiologic and pathologic features were used to determine the important effects on 3-year RFS. The addition of biologic factors to staging of rectal cancer can provide precise stratification and association with local recurrences in patients received preoperative CRT.
Article
Surgery
R. E. Clifford, D. Harji, L. Poynter, R. Jackson, R. Adams, N. S. Fearnhead, D. Vimalachandran
Summary: The high mortality rate in rectal cancer patients with COVID-19 has prompted the adoption of alternative treatment strategies. The ReCaP study aims to study these variations and associated outcomes.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Xu Guan, Ran Wei, Runkun Yang, Zhao Lu, Enrui Liu, Zhixun Zhao, Haipeng Chen, Ming Yang, Zheng Liu, Zheng Jiang, Xishan Wang
Summary: Radiotherapy for rectal cancer is associated with an increased risk of developing cancer of the uterine corpus and ovarian cancer, leading to lower survival rates. Special attention should be given to reducing the occurrence of radiotherapy-associated SGMNs and improving prognosis.
Review
Surgery
Sameh Hany Emile, Hossam Elfeki, Mostafa Shalaby, Ahmad Sakr, Nam Kyu Kim
Summary: Based on the meta-analysis, it was found that lateral pelvic lymph node dissection combined with total mesorectal excision was associated with longer operation time and higher complication rate compared to total mesorectal excision alone. However, both approaches showed similar outcomes in terms of local recurrence, distant metastasis, overall and disease-free survival.
Article
Oncology
Zhen Jia, Fang Fang, Yangsen Cao, Xiaofei Zhu, Xiaoyu Yang, Xueling Guo, Huojun Zhang
Summary: This study evaluated the efficacy and toxicity of SBRT as a replacement strategy for conventionally fractionated radiation therapy in stage III NSCLC patients. The results showed that SBRT combined with chemotherapy produced favorable treatment outcomes with acceptable toxicity. Further studies are warranted.
RADIATION ONCOLOGY
(2023)
Review
Oncology
Dilmurodjon Eshmuminov, Botirjon Aminjonov, Russell F. Palm, Giuseppe Malleo, Ryan K. Schmocker, Raef Abdallah, Changhoon Yoo, Walid L. Shaib, Marcel Andre Schneider, Elena Rangelova, Yoo Jin Choi, Hongbeom Kim, J. Bart Rose, Sameer Patel, Gregory C. Wilson, Sarah Maloney, Lea Timmermann, Klaus Sahora, Fabian Rossler, Victor Lopez-Lopez, Emanuel Boyer, Laura Maggino, Thomas Malinka, Jeong Youp Park, Matthew H. G. Katz, Laura Prakash, Syed A. Ahmad, Scott Helton, Jin-Young Jang, Sarah E. Hoffe, Roberto Salvia, Julien Taieb, Jin He, Pierre-Alain Clavien, Ulrike Held, Kuno Lehmann
Summary: Pancreatic cancer often presents as locally advanced or borderline resectable. It is currently unclear which chemotherapy is preferred for patients in these categories. This study found that initial treatment with FOLFIRINOX appears to provide a survival benefit for patients that are ultimately unresectable, compared to gemcitabine-based chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Sean Nassoiy, Wade Christopher, Rebecca Marcus, Jennifer Keller, Jessica Weiss, Shu-Ching Chang, Leland Foshag, Richard Essner, Trevan Fischer, Melanie Goldfarb
Summary: The study found that NACRT had better treatment effects for older LARC patients aged 80 and above, increasing the likelihood of achieving R0 resection and improving overall survival.
Review
Oncology
Huiwen Lu, Yimeng Sun, Zirui Zhu, Junqiao Yao, Huimian Xu, Rui Huang, Baojun Huang
Summary: This study found that adjuvant chemoradiotherapy offers significant survival benefits to advanced gastric cancer patients compared with chemotherapy alone, with similar nausea/vomiting side effects but an increased risk of neutropenia. It is strongly recommended for patients without preoperative treatment or with positive surgical margins to undergo chemoradiotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Hidde Swartjes, Jan M. van Rees, Felice N. van Erning, Marcel Verheij, Cornelis Verhoef, Johannes H. W. de Wilt, Pauline A. J. Vissers, Tijmen Koeter
Summary: This study provides a nationwide overview of locally recurrent rectal cancer (LRRC) after total mesorectal excision (TME) in the Netherlands. The study found a low incidence rate of LRRC and no significant differences in treatment and overall survival between patients treated with and without neoadjuvant treatment.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Meng Yuan, Yongxing Bao, Zeliang Ma, Yu Men, Yang Wang, Zhouguang Hui
Summary: This study conducted a network meta-analysis on different treatments for resectable esophageal cancer, finding that neoadjuvant chemoradiotherapy followed by surgery significantly improved overall survival and is the optimal treatment for patients. Future research should focus on optimizing neoadjuvant chemoradiotherapy regimens.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Wei-Wei Xiao, Min Li, Zhi-Wei Guo, Rong Zhang, Shao-Yan Xi, Xiang-Guo Zhang, Yong Li, De-Qing Wu, Yu-Feng Ren, Xiao-Lin Pang, Xiang-Bo Wan, Kun Li, Chun-Lian Zhou, Xiang-Ming Zhai, Zhi-Kun Liang, Qiao-Xuan Wang, Zhi-Fan Zeng, Hui-Zhong Zhang, Xue-Xi Yang, Ying-Song Wu, Ming Li, Yuan-Hong Gao
Summary: The PGS-LARC model is a reliable predictive tool for pCR in LARC patients, showing superior predictive performance compared to clinical factors. For patients with clinical complete response (cCR), the positive prediction value is 94.7%.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)