Article
Radiology, Nuclear Medicine & Medical Imaging
Alejandro A. Diaz, Pietro Nardelli, Wei Wang, Ruben San Jose Estepar, Andrew Yen, Seth Kligerman, Diego J. Maselli, Wojciech R. Dolliver, Andrew Tsao, Jose L. Orejas, Stefano Aliberti, Timothy R. Aksamit, Kendra A. Young, Gregory L. Kinney, George R. Washko, Edwin K. Silverman, Raul San Jose Estepar
Summary: An artificial intelligence-based CT method was used to assess bronchiectasis, and it was found that the airway-to-artery diameter ratio (AAR) was associated with exacerbations over time.
Article
Radiology, Nuclear Medicine & Medical Imaging
Samuel Y. Ash, Raul San Jose Estepar, Sean B. Fain, Ruth Tal-Singer, Robert A. Stockley, Lars H. Nordenmark, Stephen Rennard, MeiLan K. Han, Debora Merrill, Stephen M. Humphries, Alejandro A. Diaz, Stefanie E. Mason, Farbod N. Rahaghi, Carrie L. Pistenmaa, Frank C. Sciurba, Gonzalo Vegas-Sanchez-Ferrero, David A. Lynch, George R. Washko
Summary: The study found that progression of emphysema on CT scans in smokers is associated with increased all-cause and respiratory mortality rates.
Article
Radiology, Nuclear Medicine & Medical Imaging
Akinori Hata, Takuya Hino, Rachel K. Putman, Masahiro Yanagawa, Tomoyuki Hida, Aravind A. Menon, Osamu Honda, Yoshitake Yamada, Mizuki Nishino, Tetsuro Araki, Vladimir Valtchinov, Masahiro Jinzaki, Hiroshi Honda, Kousei Ishigami, Takeshi Johkoh, Noriyuki Tomiyama, David C. Christiani, David A. Lynch, Raul San Jose Estepar, George R. Washko, Michael H. Cho, Edwin K. Silverman, Gary M. Hunninghake, Hiroto Hatabu
Summary: This study investigated the association of traction bronchiectasis/bronchiolectasis index (TBI) with mortality and clinical outcomes in individuals with interstitial lung abnormalities (ILA) using the COPDGene cohort. The results showed that TBI was associated with poorer clinical outcomes and shorter survival, particularly TBI-2 and 3.
Article
Radiology, Nuclear Medicine & Medical Imaging
Surya P. Bhatt, Sandeep Bodduluri, Arie Nakhmani, Young-Il Kim, Joseph M. Reinhardt, Eric A. Hoffman, Amin Motahari, Carla G. Wilson, Stephen M. Humphries, Elizabeth A. Regan, Dawn L. Demeo
Summary: This study aimed to evaluate the possible reasons for gender differences in COPD. By quantitatively analyzing CT images, it was found that women had smaller airway lumen sizes than men after accounting for height and lung size, which contributed to the differences in clinical outcomes and survival rates between genders in COPD.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hendrik Joost Wisselink, Xiaofei Yang, Mieneke Rook, Marjolein A. Heuvelmans, Wenzhen Jiang, Jianing Zhang, Yihui Du, Marleen Vonder, Monique D. Dorrius, Zhaoxiang Ye, Geertruida H. de Bock, Rozemarijn Vliegenthart
Summary: This study proposes a method to evaluate emphysema by splitting it into more categories and assessing each lobe separately, which adds information to the original Fleischner society classification. Individuals in the same Fleischner category have different emphysema sum scores, and the distribution of emphysema in lobes differs between smokers and non-smokers.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sumedha Singla, Mingming Gong, Craig Riley, Frank Sciurba, Kayhan Batmanghelich
Summary: A deep learning model was developed and evaluated to extract rich information from HRCT of COPD patients, predicting disease severity and outcomes accurately. The model showed strong predictive power for spirometric obstruction, emphysema severity, exacerbation risk, and mortality from CT imaging alone, demonstrating potential applicability in research and clinical practice.
Article
Radiology, Nuclear Medicine & Medical Imaging
David Baraghoshi, Matthew Strand, Stephen M. Humphries, Raul San Jose Estepar, Gonzalo Vegas Sanchez-Ferrero, Jean-Paul Charbonnier, Rudolfs Latisenko, Edwin K. Silverman, James D. Crapo, David A. Lynch
Summary: This study evaluated emphysema progression in current and former smokers with chronic obstructive pulmonary disease (COPD) in the COPDGene cohort and adjusted for differences in CT equipment and scanning protocols. The results showed that patients with pre-existing emphysema who continued smoking had the largest decline in adjusted lung density (ALD) over a 10-year period. Adjusting for CT equipment and protocol factors improved these longitudinal estimates.
Article
Engineering, Biomedical
Yanan Wu, Shouliang Qi, Yu Sun, Shuyue Xia, Yudong Yao, Wei Qian
Summary: The study proposed a method for classifying subtypes of emphysema using a vision transformer model, achieving high accuracy in the lab's own dataset by extracting key information from CT images and utilizing pre-trained models.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kazutoshi Ukai, Rashedur Rahman, Naomi Yagi, Keigo Hayashi, Akihiro Maruo, Hirotsugu Muratsu, Syoji Kobashi
Summary: The study proposed an automated method to detect pelvic fractures on 3D-CT using multiple YOLOv3 models in parallel to detect 2D fracture candidates in different orientations and integrate them to obtain the 3D fracture region. The method showed promising performance in validation phase.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Taeyoung Yun, Hyewon Choi, Hyungjin Kim, Kwon Joong Na, Samina Park, In Kyu Park, Chang Hyun Kang, Jin Mo Goo, Young Tae Kim
Summary: This study evaluated the association between visual emphysema on preoperative CT and respiratory complications and prolonged air leak in smokers undergoing lobectomy. The results showed an association between visual emphysema and PAL and respiratory complications.
EUROPEAN RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Thuy D. Do, Stephan Skornitzke, Uta Merle, Maximilian Kittel, Stefan Hofbaur, Claudius Melzig, Hans-Ulrich Kauczor, Mark O. Wielpuetz, Oliver Weinheimer
Summary: Fully automatic lung quantification based on spectral CT and laboratory parameters can be used for prognostic prediction in COVID-19 pneumonia, and it can predict the need for invasive ventilation in patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yousef Shahin, Samer Alabed, Dheyaa Alkhanfar, Juerg Tschirren, Alex M. K. Rothman, Robin Condliffe, James M. Wild, David G. Kiely, Andrew J. Swift
Summary: This study quantitatively analyzed CT pulmonary angiography to assess the volumes of peel pulmonary vessels and small pulmonary vessels in different subtypes of pulmonary hypertension (PH). The results showed that the volume of small pulmonary vessels is reduced in pulmonary arterial hypertension and PH associated with left heart disease, while the volume of peel vessels is similar to that of the control group. In patients with PH, the volume of small pulmonary vessels is correlated with pulmonary function tests.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea S. Oh, David Baraghoshi, David A. Lynch, Samuel Y. Ash, James D. Crapo, Stephen M. Humphries
Summary: This study evaluated the clinical and imaging significance of using a deep learning algorithm to assess the severity of emphysema in sequential CT scans of cigarette smokers. The results showed significant differences in functional impairment and mortality risk between the emphysema progression group and the nonprogressive group.
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiang Cai, Natthaya Triphuridet, Yeqing Zhu, Nan You, Rowena Yip, David F. Yankelevitz, Claudia Henschke
Summary: Bronchiectasis is prevalent in smokers undergoing low-dose CT screening, and the occurrence of respiratory symptoms and acute events increases with the severity of the Early Lung and Cardiac Action Program Bronchiectasis score.
Article
Oncology
Xiangyi Zan, Zhaofeng Chen, Qinghong Guo, Yuping Wang, Zhiyi Zhang, Rui Ji, Ya Zheng, Jinhua Zhang, Zhengqi Wu, Min Li, Xiang Wang, Yuwei Ye, Xiaohua Li, Feng An, Chuanggui Xu, Linzhi Lu, Ping Fan, Jun Zhang, Quanlin Guan, Qiang Li, Min Liu, Qian Ren, Xiaobin Hu, Hong Lu, Yuling Wang, Hongling Zhang, Yue Zhao, Xi Gou, Xiaochuang Shu, Jun Wang, Zenan Hu, Rong Liu, Hao Yuan, Jiankang Liu, Liang Qiao, Yongning Zhou
Summary: Based on a study of the general population in China, it was found that TFFs were significantly associated with gastric cancer and premalignant lesions (PMLs). Serum TFFs can improve the screening of high-risk populations for gastric cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Rheumatology
Jonneke S. Kuperus, Job F. Waalwijk, Elizabeth A. Regan, Irene E. van der Horst-Bruinsma, F. Cumhur Oner, Pim A. de Jong, Jorrit-Jan Verlaan
Article
Clinical Neurology
Jonathan T. Heinzman, Karin F. Hoth, Michael H. Cho, Phuwanat Sakornsakolpat, Elizabeth A. Regan, Barry J. Make, Gregory L. Kinney, Frederick S. Wamboldt, Kristen E. Holm, Nicholas Bormann, Julian Robles, Victor Kim, Anand S. Iyer, Edwin K. Silverman, James D. Crapo, Shizhong Han, James B. Potash, Gen Shinozaki
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Article
Orthopedics
Richard Meehan, Chris Wilson, Eric Hoffman, Lynne Altimier, Maryanne Kaessner, Elizabeth A. Regan
JOURNAL OF ORTHOPAEDIC RESEARCH
(2019)
Article
Cardiac & Cardiovascular Systems
Jean-Paul Charbonnier, Esther Pompe, Camille Moore, Stephen Humphries, Bram van Ginneken, Barry Make, Elizabeth Regan, James D. Crapo, Eva M. van Rikxoort, David A. Lynch
RESPIRATORY MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Elizabeth A. Regan, Craig P. Hersh, Peter J. Castaldi, Dawn L. DeMeo, Edwin K. Silverman, James D. Crapo, Russell P. Bowler
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2019)
Article
Psychiatry
Anand S. Iyer, Kristen E. Holm, Surya P. Bhatt, Victor Kim, Gregory L. Kinney, Frederick S. Wamboldt, Michael R. Jacobs, Elizabeth A. Regan, Hilary F. Armstrong, Katherine E. Lowe, Carlos H. Martinez, Mark T. Dransfield, Marilyn G. Foreman, Gen Shinozaki, Nicola A. Hanania, Robert A. Wise, Barry J. Make, Karin F. Hoth
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2019)
Article
Critical Care Medicine
Victor Kim, Huaqing Zhao, Elizabeth Regan, MeiLan K. Han, Barry Make, James D. Crapo, Paul W. Jones, Jeffrey L. Curtis, Edwin K. Silverman, Gerard J. Criner, Barry J. Make, Elizabeth A. Regan, Terri Beaty, Ferdouse Begum, Robert Busch, Peter J. Castaldi, Michael Cho, Dawn L. DeMeo, Adel R. Boueiz, Marilyn G. Foreman, Eitan Halper-Stromberg, Nadia N. Hansel, Megan E. Hardin, Lystra P. Hayden, Craig P. Hersh, Jacqueline Hetmanski, Brian D. Hobbs, John E. Hokanson, Nan Laird, Christoph Lange, Sharon M. Lutz, Merry-Lynn McDonald, Margaret M. Parker, Dandi Qiao, Stephanie Santorico, Emily S. Wan, Sungho Won, Jean-Paul Charbonnier, Harvey O. Coxson, Eric A. Hoffman, Stephen Humphries, Francine L. Jacobson, Philip F. Judy, Ella A. Kazerooni, Alex Kluiber, David A. Lynch, John D. Newell, James C. Ross, Raul San Jose Estepar, Jered Sieren, Berend C. Stoel, Juerg Tschirren, Edwin Van Beek, Brain van Ginneken, Eva van Rikxoort, George Washko, Carla G. Wilson, Robert Jensen, Douglas Everett, Jim Crooks, Camille Moore, Matt Strand, John Hughes, Gregory Kinney, Katherine Pratte, Kendra A. Young, Carlos H. Martinez, Perry G. Pernicano, Nicola Hanania, Philip Alapat, Mustafa Atik, Venkata Bandi, Aladin Boriek, Kalpatha Guntupalli, Elizabeth Guy, Arun Nachiappan, Amit Parulekar, Craig Hersh, Graham Barr, John Austin, Belinda D'Souza, Gregory D. N. Pearson, Anna Rozenshtein, Byron Thomashow, Neil MacIntyre, H. Page McAdams, Lacey Washington, Charlene McEvoy, Joseph Tashjian, Robert Wise, Robert Brown, Karen Horton, Allison Lambert, Nirupaina Putcha, Richard Casaburi, Alessandra Adaini, Matthew Budoff, Hans Fischer, Janos Porszasz, Harry Rossiter, William Stringer, Amir Sharafkhaneh, Charlie Lan, Christine Wendt, Brian Bell, Eugene Berkowitz, Eric L. Flenaugh, Gloria Westney, Russell Bowler, Richard Rosiello, David Pace, Gerard Criner, David Ciccolella, Francis Cordova, Chandra Dass, Gilbert D'Alonzo, Parag Desai, Michael Jacobs, Steven Kelsen, A. James Mamary, Nathaniel Marchetti, Aditi Satti, Kartik Shenoy, Robert M. Steiner, Maria Elena Vega-Sanchez, Mark Dransfield, William Bailey, Surya Bhatt, Anand Iyer, Hrudaya Nath, Gabriela Oates, Sushil Sonavane, J. Michael Wells, Joe Ramsdell, Paul Friedman, Xavier Soler, Andrew Yen, Alejandro P. Comellas, John Newell, Brad Thompson, Ella Kazerooni, Joanne Billings, Abbie Begnaud, Tadashi Allen, Frank Sciurba, Jessica Bon, Divay Chandra, Carl Fuhrman, Joel Weissfeld, Antonio Anzueto, Sandra Adams, Diego Maselli-Caceres, Mario E. Ruiz
Article
Rheumatology
Sytse F. Oudkerk, Firdaus A. A. Mohamed Hoesein, F. Cumhur Oner, Jorrit-Jan Verlaan, Pim A. de Jong, Jonneke S. Kuperus, Michael Cho, Merry-Lynn McDonald, David A. Lynch, Edwin K. Silverman, James D. Crapo, Barry J. Make, Katherine E. Lowe, Elizabeth A. Regan
JOURNAL OF RHEUMATOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonneke S. Kuperus, Sytse F. Oudkerk, Wouter Foppen, Firdaus A. Mohamed Hoesein, Willem Paul Gielis, Job Waalwijk, Elizabeth A. Regan, David A. Lynch, F. Cumhur Oner, Pim A. de Jong, Jorrit-Jan Verlaan
Letter
Respiratory System
David C. LaFon, Surya P. Bhatt, Wassim W. Labaki, Farbod N. Rahaghi, Matthew Moll, Russ P. Bowler, Elizabeth A. Regan, Barry J. Make, James D. Crapo, Raul San Jose Estepar, Alejandro A. Diaz, Edwin K. Silverman, MeiLan K. Han, Brian Hobbs, Michael H. Cho, George R. Washko, Mark T. Dransfield, J. Michael Wells
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea S. Oh, Matthew Strand, Katherine Pratte, Elizabeth A. Regan, Stephen Humphries, James D. Crapo, David A. Lynch
Article
Orthopedics
Sarah E. Lindsay, Hunter G. Lindsay, Julia Kallet, Michael R. Weaver, Douglas Curran-Everett, James D. Crapo, Elizabeth A. Regan
Summary: Biofilm-associated infections in orthopedic surgery are challenging to diagnose and difficult to treat with conventional antibiotic therapy. A study using a redox-active metalloporphyrin MnTE-2-PyP showed promising results in reducing bacterial counts and biofilm structure in a mouse model of infected fractures. This compound scavenges reactive oxygen species and modulates the redox environment, enhancing the effectiveness of antibiotic treatment for biofilm-associated infections.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Surya P. Bhatt, Sandeep Bodduluri, Arie Nakhmani, Young-Il Kim, Joseph M. Reinhardt, Eric A. Hoffman, Amin Motahari, Carla G. Wilson, Stephen M. Humphries, Elizabeth A. Regan, Dawn L. Demeo
Summary: This study aimed to evaluate the possible reasons for gender differences in COPD. By quantitatively analyzing CT images, it was found that women had smaller airway lumen sizes than men after accounting for height and lung size, which contributed to the differences in clinical outcomes and survival rates between genders in COPD.
Article
Respiratory System
Rachel N. Criner, Wassim W. Labaki, Elizabeth A. Regan, Jessica M. Bon, Xavier Soler, Surya P. Bhatt, Susan Murray, John E. Hokanson, Edwin K. Silverman, James D. Crapo, Jeffrey L. Curtis, Fernando J. Martinez, Barry J. Make, MeiLan K. Han, Carlos H. Martinez
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2019)