Article
Infectious Diseases
Alexandra T. Geanacopoulos, Susan C. Lipsett, Alexander W. Hirsch, Michael C. Monuteaux, Mark Neuman
Summary: Among children undergoing pneumonia evaluation in the pediatric emergency department, the presence of viral features alone on chest radiograph is not associated with increased antibiotic use. Children with viral features and radiographic pneumonia are less likely to receive antibiotics compared to those with radiographic pneumonia alone.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Veterinary Sciences
Jonathan D. Dear, William Vernau, Eric G. Johnson, Sean E. Hulsebosch, Lynelle R. Johnson
Summary: This study examined cats with aspiration pneumonia and bronchopneumonia, finding that cats with AP were less likely to present with cough, more likely to be hypothermic, and had a shorter duration of signs compared to cats with BP or IAD. Radiographically, cats with AP were more likely to exhibit an alveolar pattern and higher total score than cats with BP or IAD.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Qinyi Zhang, Jianhua Shu, Chen Chen, Zhaohang Teng, Zongyun Gu, Fangfang Li, Junling Kan
Summary: Pneumonia is a common and serious infectious disease, especially with the outbreak of COVID-19. Early detection and treatment of pneumonia are crucial. However, the complex features of pneumonia images hinder the accuracy of classification models. It is difficult to achieve high classification accuracy by directly optimizing current network models.
FRONTIERS IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fang Wang, Xiaoming Li, Ru Wen, Hu Luo, Dong Liu, Shuai Qi, Yang Jing, Peng Wang, Gang Deng, Cong Huang, Tingting Du, Limei Wang, Hongqin Liang, Jian Wang, Chen Liu
Summary: This study developed a deep learning algorithm called Pneumonia-Plus, based on CT images, to accurately classify bacterial, fungal, and viral pneumonia. The algorithm's performance was compared to that of three radiologists using a nonoverlapping dataset of 173 patients, and it showed significant improvement in diagnosing bacterial and viral pneumonia compared to the radiologists.
EUROPEAN RADIOLOGY
(2023)
Review
Virology
Ying Zheng, Ling Wang, Suqin Ben
Summary: This paper conducted a meta-analysis on the chest CT manifestations of COVID-19 pneumonia patients, finding significant differences in CT images between common patients and severe patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giorgio Maria Masci, Antonella Izzo, Giacomo Bonito, Livia Marchitelli, Elisa Guiducci, Simone Ciaglia, Sonia Lucchese, Laura Corso, Alessandra Valenti, Lucia Malzone, Patrizia Pasculli, Maria Rosa Ciardi, Giuseppe La Torre, Gioacchino Galardo, Francesco Alessandri, Francesco Vullo, Lucia Manganaro, Franco Iafrate, Carlo Catalano, Paolo Ricci
Summary: The impact of vaccination on SARS-CoV-2 infection and COVID-19 pneumonia was evaluated by assessing lung disease severity using the CT severity score. Vaccinated patients had significantly lower CT scores compared to unvaccinated patients, and unvaccinated patients had worse clinical outcomes. Vaccination status had the strongest association with the severity of COVID-19, more than age, gender, and number of doses administered.
Article
Oncology
Aiben Huang, Yang Xu, Xuelei Zang, Chongchong Wu, Jie Gao, Xiaoli Sun, Mei Xie, Xidong Ma, Hui Deng, Jialin Song, Fangping Ren, Li Pang, Jin Qian, Zhaofeng Yu, Shiyu Wan, Yuanyuan Chen, Lei Pan, Guanglei Zhuang, Sanhong Liu, Xinying Xue
Summary: Immunotherapy is increasingly used in treating NSCLC, but it can lead to a rare and life-threatening event known as CIP. This study found differences in radiological patterns and prognosis between early- and late-onset CIP cases, with early-onset cases having higher CTCAE grades and poorer prognosis compared to late-onset cases. Identifying these differences can help clinicians diagnose and treat CIP more effectively.
Article
Virology
Ghazanfar Latif, Hamdy Morsy, Asmaa Hassan, Jaafar Alghazo
Summary: COVID-19 pandemic continues to infect millions, and testing individuals for the disease is a time-consuming process. The currently developed vaccines do not prevent infection, but rather reduce symptom severity. Therefore, there is an urgent need for an automated system to detect and diagnose COVID-19, as well as future health conditions.
Article
Medicine, General & Internal
Ruichao Niu, Shuming Ye, Yongfeng Li, Hua Ma, Xiaoting Xie, Shilian Hu, Xiaoming Huang, Yangshu Ou, Jie Chen
Summary: This study investigated the relationship between chest CT findings and clinical characteristics of COVID-19 patients, revealing that different CT features are associated with the severity and prognosis of patients with the disease.
ANNALS OF MEDICINE
(2021)
Article
Microbiology
Zhiqi Yang, Daiying Lin, Xiaofeng Chen, Jinming Qiu, Shengkai Li, Ruibin Huang, Zhijian Yang, Hongfu Sun, Yuting Liao, Jianning Xiao, Yanyan Tang, Xiangguang Chen, Sheng Zhang, Zhuozhi Dai
Summary: This study compared CT imaging and clinical features between COVID-19 and influenza pneumonia in the early stage, and found that they can be distinguished based on these features, with crazy-paving pattern and white blood cell count playing the most important role in the differential diagnosis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Shuyi Liu, Huanchu Yuan, Bin Zhang, Wei Li, Jingjing You, Jing Liu, Qingyang Zhong, Lu Zhang, Luyan Chen, Shaolin Li, Yujian Zou, Shuixing Zhang
Summary: Patients in the familial cluster group with COVID-19 pneumonia had a worse clinical course and outcome compared to those in the non-familial group, requiring close monitoring and follow-ups.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Andrej Romanov, Michael Bach, Shan Yang, Fabian C. Franzeck, Gregor Sommer, Constantin Anastasopoulos, Jens Bremerich, Bram Stieltjes, Thomas Weikert, Alexander Walter Sauter
Summary: The study demonstrated that imaging biomarkers derived from deep learning segmentation-based histogram and HU threshold analysis can effectively differentiate healthy lungs from lungs with viral pneumonia. The absolute high attenuation area [600-0 HU] showed the strongest correlation with disease severity.
Article
Critical Care Medicine
Sujith Cherian, Dhara Patel, Stephen Machnicki, David Naidich, Diane Stover, William D. Travis, Kevin K. Brown, Jason J. Naidich, Akhilesh Mahajan, Michael Esposito, Bushra Mina, Viera Lakticova, Stuart L. Cohen, Nestor L. Muller, Jenna Schulner, Rakesh Shah, Suhail Raoof
Summary: Organizing pneumonia is a lung disease characterized by the filling of alveoli and bronchioles with loose connective tissue. It can be caused by various factors, and its clinical and radiographic presentations are diverse. Histopathologic confirmation and exclusion of other causes may be necessary for diagnosis. Treatment usually involves long-term steroid use, but relapses are common.
Article
Mathematical & Computational Biology
Fudan Zheng, Liang Li, Xiang Zhang, Ying Song, Ziwang Huang, Yutian Chong, Zhiguang Chen, Huiling Zhu, Jiahao Wu, Weifeng Chen, Yutong Lu, Yuedong Yang, Yunfei Zha, Huiying Zhao, Jun Shen
Summary: Computed tomography (CT) is an efficient method for diagnosing COVID-19, but developing an automatic CT image diagnosis system is necessary for assisting doctors due to the time and concentration required in reading CT films. This study focused on distinguishing COVID-19 from typical viral pneumonia using a newly developed model combining ResNet50 and SE blocks, achieving high accuracy and performance in classification.
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinxin Yu, Shuai Zhang, Jingxu Xu, Yong Huang, Hao Luo, Chencui Huang, Pei Nie, Yan Deng, Ning Mao, Ran Zhang, Lin Gao, Sha Li, Bing Kang, Ximing Wang
Summary: A nomogram combining clinical variables and CT-based radiomics features was developed and validated to differentiate pneumonia-type IMA from pneumonia. The nomogram outperformed the clinical model and two cardiothoracic radiologists in terms of diagnostic performance. The findings support potential clinical use of the nomogram for diagnosing pneumonia-type IMA in patients with consolidation on chest CT.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Infectious Diseases
Moonsuk Bae, Yunseo Jeong, Seongman Bae, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jiwon Jung
Summary: The study found that in patients with uncomplicated Pseudomonas aeruginosa bloodstream infection, there was no significant difference in recurrence rates or 30-day mortality between short-course and prolonged-course antimicrobial therapy. Prolonged therapy did not significantly reduce the risk of P. aeruginosa infection recurrence within 180 days compared to short-course therapy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Review
Immunology
Sang Ho Choi, Antoni Cesar, Timothy Arthur Chandos Snow, Naveed Saleem, Nishkantha Arulkumaran, Mervyn Singer
Summary: This study found that the efficacy of doxycycline is comparable to macrolides or fluoroquinolones in adult patients with mild-to-moderate community-acquired pneumonia (CAP), suggesting that it is a viable treatment option. However, larger trials are needed to confirm these findings due to the lack of recent studies.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Haein Kim, Hyeonji Seo, Sunghee Park, Hyemin Chung, Heungsup Sung, Mi-Na Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Yong Pil Chong
Summary: The clinical significance of Clostridium tertium bacteremia remains uncertain. This study evaluated the incidence, clinical characteristics, and outcomes of C. tertium bacteremia in neutropenic and non-neutropenic patients. It was found that 10% of patients with Clostridium species bacteremia had C. tertium bacteremia, with a higher prevalence in patients with recent chemotherapy and neutropenia or hematologic malignancy.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Seongman Bae, Eun Sil Kim, Yun Woo Lee, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim
Summary: This study evaluated the clinical characteristics of rifampicin-resistant Staphylococcus aureus (MRSA) infections and found a significant association between rifampicin resistance and infection recurrence.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Medicine, General & Internal
Jiyoung Lee, Euijin Chang, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang -Oh Lee, Sang -Ho Choi, Yang Soo Kim, Seongman Bae
Summary: This study evaluated the rate and composition of bacterial co-infection in COVID-19 patients and assessed the association between the use of empirical antibacterials and mortality. The results showed that bacterial co-infection was infrequent in the patients, and the co-infected organisms varied depending on the previous use of antibacterial drugs.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Virology
Sung-Woon Kang, Ji Yeun Kim, Heedo Park, So Yun Lim, Jeonghun Kim, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Man-Seong Park, Sung-Han Kim
Summary: Comparing transmission rates and viral shedding kinetics between Delta and Omicron variants in hospitalized patients, it was found that Omicron had a higher secondary attack rate and shorter shedding period.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Dermatology
Hyejin Park, Seongman Bae, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim, Jiwon Jung
Summary: This study retrospectively analyzed the clinical characteristics and outcomes of invasive and non-invasive fusariosis in South Korea. Invasive fusariosis mainly affected immunocompromised patients and was associated with a poor prognosis. Non-invasive fusariosis was common in patients with diabetes and solid cancer.
Article
Dermatology
Moonsuk Bae, Joon Seon Song, Ji Yeun Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Summary: This study investigated the molecular evidence of invasive mould pneumonia in lung tissues of patients diagnosed with organising pneumonia (OP) and suspected invasive mould pneumonia. The results showed that 6 out of 15 lung tissue samples (40%) exhibited molecular evidence of invasive mould infection.
Article
Microbiology
Hojun Lee, Hanhyeok Im, Seung-Ho Hwang, Duhyun Ko, Sang Ho Choi
Summary: In this study, independent component analysis (ICA) was used to analyze the transcriptome data of Vibrio vulnificus and identified two novel genes, cabH and brpN, which are regulated by BrpT and essential for biofilm and rugose colony formation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kum Ju Chae, Soyeoun Lim, Joon Beom Seo, Hye Jeon Hwang, Hyemi Choi, David Lynch, Gong Yong Jin
Summary: This study determined the prevalence and optimal threshold for detecting interstitial lung abnormalities (ILA) with lung cancer screening CT using deep learning-based texture analysis. ILAs were observed in 4% of the Korean lung cancer screening population, and a 1.8% lung area threshold showed high sensitivity and specificity for ILA detection.
Article
Chemistry, Analytical
Sang Ho Choi, Heenam Yoon
Summary: In this study, a deep learning framework was developed to estimate the respiration rate (RR) and heart rate (HR) in real time during sleep using contactless impulse radio ultrawide-band (IR-UWB) radar. The framework showed promising results with average mean absolute errors of 2.67 for RR and 4.78 for HR. This model has potential applications in health management through vital sign monitoring in home environments.
Review
Infectious Diseases
Sang -Ho Choi, Antoni Cesar, Timothy Arthur Chandos Snow, Naveed Saleem, Nishkantha Arulkumaran, Mervyn Singer
Summary: For hospitalized adults with mild-to-moderate community-acquired pneumonia (CAP), respiratory fluoroquinolone monotherapy or β-lactam plus macrolide combination therapy are suggested as first-line options according to guidelines. However, the efficacy of these regimens has not been adequately evaluated.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Medicine, General & Internal
Seong-Ho Choi, Ji Young Park, Oh Joo Kweon, Joung Ha Park, Min-Chul Kim, Yaeji Lim, Jin-Won Chung
Summary: Before the omicron era, health care workers in Korea were vaccinated with either a combination of ChAdOx1 nCoV-19 and BNT162b2 vaccines or two doses of BNT162b2 followed by a booster dose of BNT162b2. The cellular and humoral immune responses were lower in the group receiving the combination vaccine, leading to faster breakthrough infections compared to the group receiving only BNT162b2 vaccines.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Correction
Medicine, Research & Experimental
Jeongjae Lee, A. Reum Kim, Sung Woon Kang, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Jeongjae Lee, A. Reum Kim, Sung Woon Kang, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Summary: A study in Seoul, South Korea found that patients with moderate to severe immunocompromised conditions had a longer duration of SARS-CoV-2 pneumonia, longer viral clearance time, and higher COVID-19-related mortality compared to those without these conditions.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)