Review
Dentistry, Oral Surgery & Medicine
Falk Schwendicke, Joachim Krois
Summary: Precision dentistry refers to tailoring diagnostics and therapy to an individual, based on modeling, prediction, and rigorous testing. Most dental research focuses on showing associations rather than making predictions, and the datasets used are narrow. Utilizing diverse and broad data through advanced analytics can lead to more precise oral and dental care.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Oncology
Richard C. Wang, Zhixiang Wang
Summary: The concept of precision medicine, based on genomics, emerged after the Human Genome Project. Precision medicine allows tailored treatment for different patient subpopulations based on their susceptibility to specific diseases or responsiveness to specific therapies. This review examines the history, development, and future perspective of precision medicine and discusses its concepts, principles, tools, and applications.
Article
Agriculture, Multidisciplinary
H. Royer, J. L. Yengue, N. Bech
Summary: As cities expand, interest in urban culture (UA) is growing due to its ability to address city-specific issues, including nature conservation. However, the definition and forms of UA, as well as its biodiversity, are still not fully understood. UA exists in various forms, from traditional gardens to modern urban farms and green spaces. Research shows that UA can support significant biodiversity and contribute to nature conservation in cities, but further studies are needed to better understand its ecological implications. It is recommended to consider UA not only for its benefits to humans but also as a habitat for non-human beings.
AGRICULTURE ECOSYSTEMS & ENVIRONMENT
(2023)
Review
Medicine, General & Internal
Fieke E. M. Froeling, Raffaella Casolino, Antonio Pea, Andrew V. Biankin, David K. Chang
Summary: Significant progress has been made in understanding the molecular basis of cancer, providing new therapeutic targets for personalized medicine, but pancreatic cancer remains a deadly solid malignancy due to its molecular heterogeneity and trial design challenges. A new paradigm in drug development is needed to validate molecular subtypes and improve clinical outcomes for patients with pancreatic cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Bianca Tesi, Catherine Boileau, Kym M. Boycott, Guillaume Canaud, Mark Caulfield, Daniela Choukair, Sue Hill, Malte Spielmann, Anna Wedell, Valtteri Wirta, Ann Nordgren, Anna Lindstrand
Summary: Molecular diagnostics plays a crucial role in tailoring individual treatment and care based on molecular data. Genome sequencing (GS) is emerging as the primary method for precision diagnostics in rare diseases, due to its improved diagnostic yield and ability to detect a broad range of genetic aberrations. By integrating precision medicine into clinical practice, GS can accelerate targeted drug development and improve patient management in rare diseases.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Alina Nicheperovich, Andrea Townsend-Nicholson
Summary: This review suggests that detection of Smo variants through tumor profiling could lead to increased precision and improved outcomes of anti-cancer treatments.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Geriatrics & Gerontology
Mark Frasier, Brian K. Fiske, Todd B. Sherer
Summary: This article provides a current perspective on the potential and challenges of subtype identification and precision medicine approaches in Parkinson's disease. It highlights the importance of molecular characteristics and the potential for targeted interventions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
T. Joda, A. W. K. Yeung, K. Hung, N. U. Zitzmann, M. M. Bornstein
Summary: This essay discusses the impact of artificial intelligence on the field of dentistry, including electronic health data management, healthcare applications, and service operations. AI systems help strengthen personalized dental medicine workflows, optimizing treatment strategies and risk management.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Steven J. Staffa, Daniel S. Kohane, David Zurakowski
Summary: Synergy, a specific term in the field of nanoformulations, refers to the phenomenon where the combined effect of two or more drugs or therapeutic modalities is greater than the sum of their individual effects. It is important to understand and accurately demonstrate synergy in nanoscience research.
Article
Computer Science, Hardware & Architecture
Samuel Kounev, Nikolas Herbst, Cristina L. Abad, Alexandru Iosup, Ian Foster, Prashant Shenoy, Omer Rana, Andrew A. Chien
Summary: Full automation of IT infrastructure and efficient IT operations as billed services have long been goals of the computing industry. Serverless computing, a newcomer in the late 2010s, claims to have different features from established IT services, but there is still no consensus on its unique characteristics and how they differ from classical cloud computing.
COMMUNICATIONS OF THE ACM
(2023)
Review
Pharmacology & Pharmacy
Yeuan Ting Lee, Yi Jer Tan, Chern Ein Oon
Summary: Cancer is a major global cause of death and a continuing threat to human health. Drug resistance is a significant challenge in cancer treatment, and developing new drugs targeting malignant cells is a high priority. Benzimidazole and its derivatives have shown potential as anticancer therapeutics through various mechanisms, making them an important focus in medicinal chemistry and biology. This review provides updates on the mechanisms and structure-activity relationships of benzimidazole derivatives, from conventional anticancer treatments to precision healthcare. (c) 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Biochemistry & Molecular Biology
Bryan Oronsky, Scott Caroen, Tony Reid
Summary: Inflammation is an overused and vague term in medicine. Although it is often seen as a negative and out-of-control response, the importance of inflammation to health and survival is frequently overlooked. Defining inflammation precisely helps in better managing it.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Julie Smeyers, Elena-Gaia Banchi, Morwena Latouche
Summary: The non-coding repeat expansion in the C9ORF72 gene is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis. After a decade of research, it has been found that the toxic accumulation of gain-of-function products and the loss of function may both contribute to the disease.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
History & Philosophy Of Science
Liliana Albertazzi
Summary: Experimental phenomenology studies the appearances in subjective awareness, challenging various aspects of the current consciousness debate. The lack of a robust theoretical framework for understanding consciousness has led to ongoing debates on the observables to be measured and how to measure them accurately. This has resulted in many misunderstandings that obstruct a fair evaluation of the enlightening outcomes of experimental phenomenology.
Article
Genetics & Heredity
C. K. Nkera-Gutabara, R. Kerr, J. Scholefield, S. Hazelhurst, J. Naidoo
Summary: Limited access to disease monitoring technologies and poor understanding of biological and environmental factors are barriers to precision medicine efforts in low to middle income countries. The rich genetic diversity in Southern Africa necessitates alternative strategies for predicting disease risk. The human microbiome, which has an impact on health, should be included in precision medicine approaches.
FRONTIERS IN GENETICS
(2022)
