Article
Anatomy & Morphology
Brandon M. Sibbach, Helmet T. Karim, Daniel Lo, Nithya Kasibhatla, Tales Santini, Jessica C. Weber, Tamer S. Ibrahim, Layla Banihashemi
Summary: This study used ultra-high field MRI modalities to isolate subregions of the hypothalamus and bed nucleus of the stria terminalis, and generated probabilistic atlases, providing resources for further research on stress-related function and psychopathology.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Multidisciplinary Sciences
Shane B. Johnson, Ryan T. Lingg, Timothy D. Skog, Dalton C. Hinz, Sara A. Romig-Martin, Victor Viau, Nandakumar S. Narayanan, Jason J. Radley
Summary: This study explores the link between behavioral and biological features of stress responses in the brain. It identifies the involvement of the medial prefrontal cortex (mPFC) and midbrain dorsolateral periaqueductal gray (PAG) in active stress coping behaviors, while a different circuit involving the rostral mPFC and ventrolateral PAG limits passive behaviors. Furthermore, the activation of the caudal mPFC-dorsolateral PAG projection can attenuate the increase in stress hormone output and immobility associated with a passive coping response. These findings provide insights into how the brain coordinates different responses to stress and contributes to stress resilience.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Neurosciences
Xinxin Wang, Shenglin Ge, Chengxin Zhang
Summary: The bed nuclei of the stria terminalis (BST) play a crucial role in monitoring emotional valence and regulating anxiety-related behaviors. Recent research has used various techniques to study the dynamic activities and connectivity patterns of BST, uncovering the complex circuitry mechanisms underlying anxiety. This review focuses on the role of neuromodulators in anxiety within the BST and provides a comprehensive architecture of the anxiety network, highlighting the BST as a key hub in orchestrating anxiety-like behavior. These efforts will contribute to the development of effective treatments for anxiety disorders.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Behavioral Sciences
William J. Giardino, Matthew B. Pomrenze
Summary: The intricate relationship between sleep, emotional arousal, and neural circuits presents a significant challenge in understanding the impact of sleep quality on emotional responses. Investigating these interrelated factors can provide crucial insights into improving psychiatric treatments and global psychological wellbeing.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Song-Lin Ding
Summary: The bed nucleus of stria terminalis (BST) is an important structure that mediates sustained vigilant responses. Dysfunction of the BST may lead to excessive anxiety and hypervigilance. This study identifies a new BST subdivision, called BSTsc, which has unique inputs, cell morphology, and molecular signature compared to other BST subdivisions. The BSTsc appears to be a shortcut bridge linking spatial information to internal responses.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Behavioral Sciences
Matthew A. Cooper, Mackenzie K. Hooker, Conner J. Whitten, Jeff R. Kelly, Matthew S. Jenkins, Steve C. Mahometano, Maya C. Scarbrough
Summary: The medial amygdala controls social behavior and regulates responses to stress. Dominant animals showed higher neural activity in BNST-projecting MePD and MePV cells after winning or losing a social encounter. This pathway is associated with both aggression and stress coping responses.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Di Zhao, Dan Wang, Wentao Wang, Juanjuan Dai, Minghu Cui, Min Wu, Cuilan Liu, Jing Liu, Fantao Meng, Kaixin Wang, Fengai Hu, Dunjiang Liu, Changyun Qiu, Wei Li, Chen Li
Summary: The dysregulation of neuronal networks contributes to the etiology of psychiatric diseases, including anxiety. This study identified the paraventricular thalamus (PVT) as a crucial anxiety-regulating nucleus and the IC-PVT-BNST neural projection as an essential pathway affecting anxiety morbidity and treatment.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Marc Lanzillo, Manon Gervais, Sophie Croizier
Summary: This study utilized a DiI-based tracing approach to investigate the development of BNST projections to various hypothalamic areas, revealing that projections from the dorsomedial division of the anterior BNST are immature at birth but reach key hypothalamic nuclei at P10. The density of projections to the ARH increases significantly between P12 and P14, shedding light on the ontogeny of hypothalamic circuits and the role of developmental context in their formation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Anna Barbara Borges-Assis, Daniela Lescano Uliana, Sara Cristina Hott, Francisco Silveira Guimara, Sabrina Francesca Lisboa, Leonardo Barbosa Moraes Resstel
Summary: The endocannabinoid anandamide (AEA) can decrease the release of neurotransmitters by binding to presynaptic cannabinoid type 1 (CB1) receptors. AEA is hydrolyzed by the enzyme FAAH in the postsynaptic neuron. The present study investigated the role of AEA and CB1 receptors in the Bed Nucleus of the Stria Terminalis (BNST) in modulating anxiety-related behaviors. The findings suggest that eCB signaling in the BNST is recruited during aversive situations to counteract the stress effect.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Malini Suresh Nair, Nigel C. Dao, Daniela Lopez Melean, Keith R. Griffith, W. David Starnes, J. Brody Moyer, Avery R. Sicher, Dakota F. Brockway, Kathleen D. Meeks, Nicole A. Crowley
Summary: This study found that somatostatin neurons in the bed nucleus of the stria terminalis (BNST) can reduce binge alcohol consumption in female animals, but not in males. Activation of these neurons did not affect anxiety-like behavior. The findings suggest that somatostatin neurons in the BNST may be a potential target for modulating alcohol use disorder.
BRAIN RESEARCH BULLETIN
(2022)
Article
Endocrinology & Metabolism
Kuldeep Shrivastava, Thaarini Swaminathan, Alessandro Barlotta, Vikshar Athreya, Hassan Choudhry, Mark A. Rossi
Summary: Maternal overnutrition during gestation and lactation leads to increased body weight in offspring, which normalizes after weaning but predisposes them to diet-induced obesity in adulthood. This is associated with altered synaptic strength in an extended amygdala-lateral hypothalamic pathway, which is influenced by developmental growth rate.
MOLECULAR METABOLISM
(2023)
Article
Dentistry, Oral Surgery & Medicine
F. Xiao, A. Hu, B. Meng, Y. Zhang, W. Han, J. Su
Summary: A PVH-Peri5 circuit has been found to be involved in the stress response, through its associations with oromotor movements and anxiety-like behaviors.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Neurosciences
Arash Kamali, Mahdie Hosseini, Anusha Gandhi, John A. Lincoln, Khader M. Hasan
Summary: The hypothalamus and other limbic gray matter nuclei play essential roles in regulating various behaviors and activities in the human brain. However, the detailed anatomy of the connectivity between these regions and the occipital cortex is still unknown. This study aimed to use advanced techniques to map the connectivity pathways between the occipital cortex and central limbic gray matter nuclei in the human brain. The researchers successfully delineated and reconstructed the trajectory of these pathways in 30 healthy adult human brains for the first time.
Article
Pharmacology & Pharmacy
Si-Ting Huang, Zhi-Jing Song, Yu Liu, Wen-Chen Luo, Qian Yin, Yong-Mei Zhang
Summary: The study indicates that maternal separation may increase the firing frequency of CRF neurons in the PVN in adult mice, which can be reversed by injecting exogenous GABA into the PVN. GABAergic neurons projecting to PVN were mainly located in the anterior ventral region of the bed nucleus of the stria terminalis (BNST-AV), and the excitability of these neurons was decreased.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Luping Yin, Koichi Hashikawa, Yoshiko Hashikawa, Takuya Osakada, Julieta E. Lischinsky, Veronica Diaz, Dayu Lin
Summary: VMHvllCckar cells represent a key neural population that dynamically controls female sexual behaviors over the reproductive cycle.
Article
Neurosciences
Peter A. Santi, Robair Aldaya, Alec Brown, Shane Johnson, Tyler Stromback, Sebahattin Cureoglu, Helge Rask-Andersen
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2016)
Article
Neurosciences
Rachel M. Anderson, Ryan M. Glanz, Shane B. Johnson, Mary M. Miller, Sara A. Romig-Martin, Jason J. Radley
JOURNAL OF COMPARATIVE NEUROLOGY
(2016)
Article
Neurosciences
Shane B. Johnson, Eric B. Emmons, Rachel M. Anderson, Ryan M. Glanz, Sara A. Romig-Martin, Nandakumar S. Narayanan, Ryan T. LaLumiere, Jason J. Radley
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Keiko Hirose, Jared J. Hartsock, Shane Johnson, Peter Santi, Alec N. Salt
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2014)
Article
Otorhinolaryngology
Heather M. Schmitz, Shane B. Johnson, Peter A. Santi
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2014)
Article
Neurosciences
Shane B. Johnson, Eric B. Emmons, Ryan T. Lingg, Rachel M. Anderson, Sara A. Romig-Martin, Ryan T. LaLumiere, Nandakumar S. Narayanan, Victor Viau, Jason J. Radley
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Rachel M. Anderson, Shane B. Johnson, Ryan T. Lingg, Dalton C. Hinz, Sara A. Romig-Martin, Jason J. Radley
Article
Multidisciplinary Sciences
Ryan T. Lingg, Shane B. Johnson, Eric B. Emmons, Rachel M. Anderson, Sara A. Romig-Martin, Nandakumar S. Narayanan, James L. McGaugh, Ryan T. LaLumiere, Jason J. Radley
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Editorial Material
Neurosciences
Shane Johnson, Conor Liston
Summary: Research shows that MeCP2 signaling in the hippocampus is crucial for sustaining antidepressant effects.
NATURE NEUROSCIENCE
(2021)
Review
Neurosciences
Puja K. Parekh, Shane B. Johnson, Conor Liston
Summary: Depression is characterized by mood state transitions with poorly understood neurobiological mechanisms. Antidepressants reverse the effects of stress and depression on synapse function, suggesting that synaptic remodeling plays a key role in depression pathophysiology and antidepressant function. Antidepressants initially act by facilitating plasticity and reconfiguring the brain state, with synaptogenesis sustaining these changes over time.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Article
Audiology & Speech-Language Pathology
Peter A. Santi, Shane Johnson, Julian Wuester, Matthew Griesbach, Alexander Claussen, Jonathon Kirk
Summary: Postmortem examination of the cochlea with a cochlear implant presents challenges due to the presence of wires and metal components that make sectioning difficult. Plastic embedded implanted cochleas have been successfully sectioned using specialized methods. An alternative non-destructive method is optical sectioning of a chemically cleared cochlea, but the presence of metal components results in artifacts in the 2D optical sections. Removal of the implant prior to imaging yields the best image quality.
Article
Multidisciplinary Sciences
Shane B. Johnson, Ryan T. Lingg, Timothy D. Skog, Dalton C. Hinz, Sara A. Romig-Martin, Victor Viau, Nandakumar S. Narayanan, Jason J. Radley
Summary: This study explores the link between behavioral and biological features of stress responses in the brain. It identifies the involvement of the medial prefrontal cortex (mPFC) and midbrain dorsolateral periaqueductal gray (PAG) in active stress coping behaviors, while a different circuit involving the rostral mPFC and ventrolateral PAG limits passive behaviors. Furthermore, the activation of the caudal mPFC-dorsolateral PAG projection can attenuate the increase in stress hormone output and immobility associated with a passive coping response. These findings provide insights into how the brain coordinates different responses to stress and contributes to stress resilience.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Peter A. Santi, Shane B. Johnson
Summary: Deafness is a common sensory impairment, particularly in the elderly population. However, studying the relationship between the structure and function of the inner ear has been challenging. To overcome this, researchers have developed a light-sheet microscope that can image and digitize the entire cochlea, enabling a better understanding of its structure and function. Using this technique, researchers were able to quantify the loss of hair cells and spiral ganglion neurons, as well as observe local reductions in spiral ganglion neurons within the cochlea.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Clinical Neurology
Shane B. Johnson, Sebahattin Cureoglu, Jennifer T. O'Malley, Peter A. Santi
OTOLOGY & NEUROTOLOGY
(2014)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)