Article
Multidisciplinary Sciences
Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa
Summary: Patients with multiple sclerosis showed elevated counts of total white blood cells, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Isabel Jaramillo, Marlene Karl, Luisa Bergunde, Judith T. Mack, Victoria Weise, Kerstin Weidner, Wei Gao, Susann Steudte-Schmiedgen, Susan Garthus-Niegel
Summary: This study investigated the association between negative childbirth experiences and long-term glucocorticoids, and found that a negative objective birth experience was associated with an increased HairF/HairE ratio, which may be a biomarker for identifying women at risk for developing postpartum depression (PPD). Subjective birth experience was not directly related to hair cortisol concentrations, but was a significant predictor for PPD symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Claudio Singh Solorzano, Bianca Serwinski, Caterina Grano, Andrew Steptoe
Summary: Hair cortisol is a reliable retrospective biomarker of basal and long-term cortisol secretion, with the strongest associations found for cortisol output during the day excluding the early morning period. There was no significant association between hair cortisol and cortisol output in the morning. These findings have implications for the use of hair cortisol as an outcome measure in intervention and treatment research.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
S. Steudte-Schmiedgen, S. Schaelicke, L. Bergunde, M. Karl, V. Weise, J. Junge-Hoffmeister, S. Schumacher, T. von Soest, K. Weidner, C. Kirschbaum, S. Garthus-Niegel
Summary: Childbirth-related posttraumatic stress disorder (CB-PTSD) is associated with maternal trauma history and long-term glucocorticoid (GC) levels, but these associations were not significant after correcting for multiple testing. Trauma history predicted higher CB-PTSD symptoms, but hair GC levels did not predict or mediate the relationship between trauma history and CB-PTSD symptoms. The subjective birth experience moderated the relationship between hair GC levels and CB-PTSD symptoms.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Biology
S. Begall, R. Nappe, L. Hohrenk, T. C. Schmidt, H. Burda, A. Sahm, K. Szafranski, P. Dammann, Y. Henning
Summary: Giant mole-rats are long-lived rodents that live in family groups, with recent studies showing that the social environment within the family affects stress levels and lifespan. Orphaned non-breeders have lower levels of stress and mortality rates compared to non-breeders living with both parents, indicating a potential link between intrafamilial stress and shorter lifespan.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Nan Li, Chenbing Liu, Qian Luo, Feng Zhang, Di Sheng, Zhong Liu
Summary: Metabolic syndrome (MetS) is a global health problem, and white blood cell (WBC), neutrophils, and neutrophil-to-lymphocyte ratio (NLR) are valid indicators involved in acute and chronic inflammation. This study analyzed the correlation and severity of these indicators with MetS and its components, and explored the diagnostic value of their combined tests.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Agriculture, Dairy & Animal Science
W. Otten, T. Bartels, S. Heimbuerge, A. Tuchscherer, E. Kanitz
Summary: The study found that exposure to artificial light reduces hair cortisol concentrations in pigs and cattle, with black hair showing higher cortisol levels. Furthermore, the influence of light exposure was greater on white hair, while melanin pigments in black hair absorbed radiation, reducing the effects of photodegradation.
Article
Cardiac & Cardiovascular Systems
Nicholas H. Adamstein, Jean G. MacFadyen, Lynda M. Rose, Robert J. Glynn, Amit K. Dey, Peter Libby, Ira A. Tabas, Nehal N. Mehta, Paul M. Ridker
Summary: The study demonstrates that the neutrophil-lymphocyte ratio (NLR) can predict cardiovascular events and mortality risk, and can be reduced by anti-inflammatory therapy with canakinumab.
EUROPEAN HEART JOURNAL
(2021)
Article
Endocrinology & Metabolism
Rachel Wurth, Megan Rescigno, Chelsi Flippo, Constantine A. Stratakis, Christina Tatsi
Summary: The study found that inflammatory biomarkers in patients with Cushing syndrome (CS) differed significantly from the control group, indicating substantial effects of hypercortisolemia on the immune system.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Egle Mazgelyte, Agne Valatkeviciute, Jurgita Songailiene, Algirdas Utkus, Neringa Burokiene, Dovile Karciauskaite
Summary: Increased hair glucocorticoid levels are associated with worse sleep quality among relatively healthy perimenopausal and postmenopausal women, possibly due to increased hypothalamic-pituitary-adrenal axis activity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Psychology, Biological
Somkene Igboanugo, Claire O'Connor, Osama A. Zitoun, Reza Ramezan, John G. Mielke
Summary: This study aimed to determine reference values for hair cortisol concentration (HCC) in healthy adults. A systematic review of relevant studies was conducted, and estimates were calculated for major test kit vendors. Future research should consider potential moderating factors such as age, sex, and ethnicity when determining reference values.
Article
Clinical Neurology
Wonsuk Choi, Hee-Ju Kang, Ju-Wan Kim, Hee Kyung Kim, Ho-Cheol Kang, Ju-Yeon Lee, Sung-Wan Kim, Robert Stewart, Jae-Min Kim
Summary: This study aimed to investigate the impact of serum cortisol levels and stress-related parameters on suicidal behavior in depressed patients. The results revealed that higher serum cortisol levels and perceived stress scores were significantly associated with increased suicidal severity and more fatal/non-fatal suicide attempts in depressed patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Guowei Zhou, Xiangmei Ren, Zhenwei Tang, Wang Li, Wenqiong Chen, Yi He, Benliang Wei, Hailun Zhang, Fangyu Ma, Xiang Chen, Guanxiong Zhang, Minxue Shen, Hong Liu
Summary: This study found that elevated levels of monocytes, neutrophils, and eosinophils are associated with an increased risk of psoriasis, particularly with eosinophils having a causal relationship with psoriasis. Additionally, the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and lymphocyte-monocyte ratio were also found to be associated with psoriasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Cheng-Shyuan Rau, Spencer Chia-Hao Kuo, Ching-Hua Tsai, Sheng-En Chou, Wei-Ti Su, Shiun-Yuan Hsu, Ching-Hua Hsieh
Summary: This study found a significant association between stress-induced hyperglycemia (SIH) and increased counts of monocytes, neutrophils, and lymphocytes in trauma patients. No such association was observed in patients with normal blood glucose levels or diabetic hyperglycemia.
Article
Biochemistry & Molecular Biology
Lucas Freire-Antunes, Uyla Ornellas-Garcia, Marcos Vinicius Rangel-Ferreira, Monica Lucas Ribeiro-Almeida, Carina Heusner Goncalves de Sousa, Leonardo Jose de Moura Carvalho, Claudio Tadeu Daniel-Ribeiro, Flavia Lima Ribeiro-Gomes
Summary: New data suggests that neutrophils may both aggravate and protect against malaria. The balance of these cells in the body could impact the development of the disease. This study examined the response of neutrophils and T cells in mice infected with Plasmodium berghei ANKA, and found increased levels of neutrophils and neutrophil-T cell ratios before the onset of cerebral malaria. These findings could help predict the development of cerebral malaria and advance our understanding of its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Michael Hoefler, John Venz, Sebastian Trautmann, Robert Miller
BMC MEDICAL RESEARCH METHODOLOGY
(2018)
Article
Endocrinology & Metabolism
Nina Alexander, Clemens Kirschbaum, Matthis Wankerl, Benjamin J. Stauch, Tobias Stalder, Susann Steudte-Schmiedgen, Markus Muehlhan, Robert Miller
PSYCHONEUROENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
Robert Miller, Jan-Georg Wojtyniak, Lisa J. Weckesser, Nina C. Alexander, Veronika Engert, Thorsten Lehr
PSYCHONEUROENDOCRINOLOGY
(2018)
Article
Behavioral Sciences
Magdalena Katharina Wekenborg, LaBarron K. Hill, Robert Miller, Tobias Stalder, Julian Francis Thayer, Marlene Sophie Penz, Clemens Kirschbaum
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2018)
Article
Endocrinology & Metabolism
Liesa Ilg, Clemens Kirschbaum, Shu-Chen Li, Franziska Rosenloecher, Robert Miller, Nina Alexander
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Article
Endocrinology & Metabolism
Robert Miller, Clemens Kirschbaum
PSYCHONEUROENDOCRINOLOGY
(2019)
Review
Psychiatry
Andreas Walther, Jonas Breidenstein, Robert Miller
Article
Multidisciplinary Sciences
Lisa J. Weckesser, Friedericke Dietz, Kornelius Schmidt, Juliane Grass, Clemens Kirschbaum, Robert Miller
SCIENTIFIC REPORTS
(2019)
Article
Orthopedics
Marie Schild, Ulrike Mueller, Ursula von Schenck, Sigurd Prieur, Robert Miller
Summary: A retrospective cohort analysis of German OA patients revealed that those with chronic pain have higher healthcare resource utilization and costs. Better prevention and treatment of OA are needed to reduce the disease burden experienced by patients.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Multidisciplinary Sciences
Ruth Mokgokong, Renate Schnabel, Henning Witt, Robert Miller, Theodore C. Lee
Summary: This study validated a predictive model for atrial fibrillation originally developed in a German population, using real-world primary healthcare databases from countries in Europe and Australia. The model showed high accuracy in detecting unidentified incident AF cases. Differences in disease conditions were observed between AF patients and controls in various countries, despite varying AF prevalence rates. Risk prediction algorithms offer targeted ways to improve screening effectiveness and cost-effectiveness for AF detection in clinical practice.
Article
Psychology, Developmental
Lisa Juliane Weckesser, Kornelius Schmidt, Marcus Moeschl, Clemens Kirschbaum, Soeren Enge, Robert Miller
Summary: The study indicates that set shifting is capable of modulating the body's physiological response to chronic stress exposure, whereas executive functions appear comparably robust against chronic stress exposure.
DEVELOPMENTAL PSYCHOLOGY
(2021)
Article
Psychology, Clinical
Kornelius Schmidt, Soren Enge, Robert Miller
PSYCHOLOGICAL ASSESSMENT
(2020)
Article
Psychology, Multidisciplinary
Monika Fleischhauer, Robert Miller, Magdalena Katharina Wekenborg, Marlene Penz, Clemens Kirschbaum, Soeren Enge
FRONTIERS IN PSYCHOLOGY
(2019)
Article
Psychology, Mathematical
R. Miller, K. Schmidt, C. Kirschbaum, S. Enge
BEHAVIOR RESEARCH METHODS
(2018)
Article
Social Sciences, Mathematical Methods
Robert Miller, Stefan Scherbaum, Daniel W. Heck, Thomas Goschke, Soeren Enge
APPLIED PSYCHOLOGICAL MEASUREMENT
(2018)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)