Review
Biochemistry & Molecular Biology
E. M. Bruxel, C. R. Moreira-Maia, G. C. Akutagava-Martins, T. P. Quinn, M. Klein, B. Franke, M. Ribases, P. Rovira, C. Sanchez-Mora, D. B. Kappel, N. R. Mota, E. H. Grevet, C. H. D. Bau, M. Arcos-Burgos, L. A. Rohde, M. H. Hutz
Summary: This study conducted a meta-analysis to investigate the association between ADGRL3 gene variants and ADHD susceptibility in children and adults, finding significant correlation in children but not in adults. The results suggest that ADGRL3 gene is predominantly associated with childhood ADHD.
MOLECULAR PSYCHIATRY
(2021)
Article
Environmental Sciences
Chia-Huang Chang, Ching-Jung Yu, Jung-Chieh Du, Hsien-Chih Chiou, Jia-Woei Hou, Winnie Yang, Chian-Feng Chen, Hsin-Chang Chen, Ying-Sheue Chen, Betau Hwang, Mei-Lien Chen
Summary: This study reveals a potential link between organophosphate pesticide exposure and ADHD, related to oxidative stress and PON genetic polymorphisms. Children exposed to organophosphate pesticides may have higher levels of DMP and HNE-MA. The PON1 genetic polymorphism is associated with exposure levels and the risk of ADHD.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Luis M. Garcia-Marin, Adrian Campos, Gabriel Cuellar-Partida, Sarah E. Medland, Scott H. Kollins, Miguel E. Renteria
Summary: ADHD is a complex psychiatric and neurodevelopmental disorder that develops during childhood and spans into adulthood. Research findings indicate that genetic variants associated with iron deficiency anemia, obesity, type 2 diabetes, and other factors increase the risk of developing ADHD in children, while genetic factors related to social support and interactive activities have a protective effect against ADHD.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Ali Khorshidi, Marzieh Rostamkhani, Roya Farokhi, Abbas Abbasi-Ghahramanloo
Summary: Aging poses a major challenge to the development and growth of countries worldwide. This study identified subgroups of the elderly based on their quality of life, sleep quality, and common mental disorders, and examined the influence of demographic characteristics on subgroup membership. Three subgroups were identified: healthy, anxious with poor sleep quality, and unhealthy. Being female, living in urban areas, and illiteracy were found to increase the odds of belonging to certain subgroups. These results highlight the co-occurrence of health problems among a significant portion of the elderly population.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Ditte Demontis, G. Bragi Walters, Georgios Athanasiadis, Raymond Walters, Karen Therrien, Trine Tollerup Nielsen, Leila Farajzadeh, Georgios Voloudakis, Jaroslav Bendl, Biau Zeng, Wen Zhang, Jakob Grove, Thomas D. Als, Jinjie Duan, F. Kyle Satterstrom, Jonas Bybjerg-Grauholm, Marie Baekved-Hansen, Olafur O. Gudmundsson, Sigurdur H. Magnusson, Gisli Baldursson, Katrin Davidsdottir, Gyda S. Haraldsdottir, Esben Agerbo, Gabriel E. Hoffman, Soren Dalsgaard, Joanna Martin, Marta Ribases, Dorret Boomsma, Maria Soler Artigas, Nina Roth Mota, Daniel Howrigan, Sarah E. Medland, Tetyana Zayats, Veera M. Rajagopal, Merete Nordentoft, Ole Mors, David M. Hougaard, Preben Bo Mortensen, Mark J. Daly, Stephen Faraone, Hreinn Stefansson, Panos Roussos, Barbara Franke, Thomas Werge, Benjamin M. Neale, Kari Stefansson, Anders D. Borglum
Summary: This study conducted a meta-analysis of genome-wide association studies on ADHD and identified 27 significant genetic loci associated with ADHD. They also found that these loci were enriched with genes involved in early brain development. Moreover, they discovered an increased load of rare protein-truncating variants in ADHD, implicating SORCS3 as a potential gene involved in ADHD.
Correction
Biochemistry & Molecular Biology
Maria Soler Artigas, Cristina Sanchez-Mora, Paula Rovira, Vanesa Richarte, Iris Garcia-Martinez, Mireia Pagerols, Ditte Demontis, Sven Stringer, Jacqueline M. Vink, Anders D. Borglum, Benjamin M. Neale, Barbara Franke, Stephen V. Faraone, Miguel Casas, Josep Antoni Ramos-Quiroga, Marta Ribases
Summary: A correction to the paper has been published.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychology, Multidisciplinary
Morgan M. Grotewiel, Megan E. Crenshaw, Amelia Dorsey, Elizabeth Street
Summary: Hyperfocus and flow are intense concentration experiences associated with reduced perception of irrelevant stimuli and improved task performance. Hyperfocus has been historically seen as a symptom of ADHD, autism, or schizophrenia, while flow is regarded as an enjoyable experience in positive psychology. Recent studies suggest that hyperfocus and flow may be the same phenomenon viewed from different perspectives.
CURRENT PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Hsin-Yi Fan, Cheuk-Kwan Sun, Yu-Shian Cheng, Weilun Chung, Ruu-Fen Tzang, Hsien-Jane Chiu, Chun-Ning Ho, Kuo-Chuan Hung
Summary: This study provides a systematic review and analysis of the effectiveness of electroencephalogram-based neurofeedback (EEG-NF) in treating the core symptoms of attention-deficit hyperactivity disorder (ADHD) in adolescents/adults. The results suggest that EEG-NF can effectively improve inattention symptoms, but its effectiveness in reducing hyperactivity/impulsivity remains inconclusive.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Miguel Garcia-Argibay, Ebba du Rietz, Yi Lu, Joanna Martin, Elis Haan, Kelli Letho, Sarah E. Bergen, Paul Lichtenstein, Henrik Larsson, Isabell Brikell
Summary: Growing evidence suggests that ADHD is associated with poor somatic health in adulthood, but the mechanisms underlying these associations are poorly understood. This study found that ADHD polygenic risk scores (PRS) are associated with multiple somatic health problems in mid-to-late life, particularly in the cardiometabolic domain. These associations were observed in the general population and appear to be partially mediated by life-course risk factors.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Dara E. Babinski, Erika F. H. Saunders, Fan He, Duanping Liao, Amanda M. Pearl, Daniel A. Waschbusch
Summary: This study examined the diagnostic indicators, clinical characteristics, and functional impairment associated with adult ADHD using electronic medical records and self-report measures. The results showed a significant difference in prevalence of ADHD between self-report screening and medical records. ADHD was found to contribute to functional impairment even when controlling for other psychiatric comorbidities.
PSYCHIATRY RESEARCH
(2022)
Article
Biology
Raly James Perez Custodio, Mikyung Kim, Leandro Val Sayson, Hyun Jun Lee, Darlene Mae Ortiz, Bung-Nyun Kim, Hee Jin Kim, Jae Hoon Cheong
Summary: This study demonstrates that reduced levels of striatal triiodothyronine (T3) due to overexpression of thyroid hormone-responsive protein in mice can lead to inattention and memory impairment, suggesting a potential pathogenetic mechanism for ADHD. The overexpression of thyroid hormone-responsive protein in male mice replicates behavioral features of ADHD, which can serve as an animal model for the predominantly inattentive subtype of ADHD. Furthermore, TH replacement therapy in these mice rescued the inattention and memory impairment, supporting the involvement of the upregulated thyroid hormone-responsive protein gene in ADHD pathology.
COMMUNICATIONS BIOLOGY
(2021)
Article
Psychiatry
Ancha Baranova, Jun Wang, Hongbao Cao, Jiang-Huan Chen, Jiu Chen, Miao Chen, Sulin Ni, Xijia Xu, Xiaoyan Ke, Shiping Xie, Jing Sun, Fuquan Zhang
Summary: This study uncovers the genetic relationships between ADHD and ASD, as well as their connections with extraversion. It also identifies novel shared genetic loci for ADHD and ASD.
PSYCHIATRY RESEARCH
(2022)
Article
Health Care Sciences & Services
Enrico Capuzzi, Martina Capellazzi, Alice Caldiroli, Francesca Cova, Anna Maria Auxilia, Paola Rubelli, Ilaria Tagliabue, Francesco Giuseppe Zanvit, Gianluca Peschi, Massimiliano Buoli, Massimo Clerici
Summary: This study investigated the prevalence of ADHD symptoms in male inmates and examined the relationship between ADHD symptoms and socio-demographic/clinical features. The results showed a high prevalence of ADHD symptoms among inmates, with childhood trauma, cocaine use disorder, prescription of mood stabilizers, and history of emotional abuse significantly associated with ADHD symptoms. Screening for ADHD and appropriate intervention strategies should be implemented.
Article
Psychiatry
Barbara D. Fontana, Florian Reichmann, Ceinwen A. Tilley, Perrine Lavlou, Alena Shkumatava, Nancy Alnassar, Courtney Hillman, Karl aegir Karlsson, William H. J. Norton, Matthew O. Parker
Summary: Externalizing disorders (ED) are a public health concern and have a high heritability. The ADGRL3 gene is strongly associated with EDs and affects various ED-related behaviors. This study found that adgrl3.1(-/-) zebrafish exhibited impulsive, risk-taking, attention deficits, and hyperactive behaviors, which could be rescued by atomoxetine. Transcriptomic analysis revealed potential functional pathways and targets for the treatment of ED.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Dermatology
Joy Wan, Nandita Mitra, Stephen R. Hooper, Ole J. Hoffstad, David J. Margolis
Summary: This cross-sectional study found that worse AD severity was associated with greater odds of reported LD, independent of socioeconomic characteristics, AD onset age, and other related disorders. Additional prospective and mechanistic studies are needed to clarify the association of AD with learning difficulties, and it is suggested that children with more severe AD should be screened for learning difficulties to initiate appropriate interventions.
Article
Clinical Neurology
Fang-fen Yuan, Xue Gu, Xin Huang, Yan Zhong, Jing Wu
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2017)
Article
Psychology, Developmental
Xin Huang, Qi Zhang, Xue Gu, Yuwei Hou, Min Wang, Xinzhen Chen, Jing Wu
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2019)
Review
Genetics & Heredity
Xin Huang, Min Wang, Qi Zhang, Xinzhen Chen, Jing Wu
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2019)
Article
Clinical Neurology
Min Wang, Xue Gu, Xin Huang, Qi Zhang, Xinzhen Chen, Jing Wu
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2019)
Article
Behavioral Sciences
Xin Huang, Qi Zhang, Xinzhen Chen, Xue Gu, Min Wang, Jing Wu
GENES BRAIN AND BEHAVIOR
(2019)
Review
Endocrinology & Metabolism
Xuejiao Chen, Wenfeng Hua, Xin Huang, Yuming Chen, Junguo Zhang, Guowei Li
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Genetics & Heredity
Junguo Zhang, Xin Huang, Xiaojie Wang, Yanhui Gao, Li Liu, Ziyi Li, Xuejiao Chen, Jie Zeng, Zebing Ye, Guowei Li
BMC MEDICAL GENOMICS
(2020)
Article
Environmental Sciences
Xiaojie Wang, Junzhang Tian, Ziyi Li, Jun Lai, Xin Huang, Yongcong He, Zebing Ye, Guowei Li
ENVIRONMENTAL HEALTH
(2020)
Review
Genetics & Heredity
Xin Huang, Yuhui Li, Junguo Zhang, Xiaojie Wang, Ziyi Li, Guowei Li
Review
Cardiac & Cardiovascular Systems
Xuejiao Chen, Guowei Li, Junguo Zhang, Xin Huang, Zebing Ye, Yahong Zhao
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)
Letter
Medicine, General & Internal
Guowei Li, Xiaojie Wang, Ziyi Li, Xin Huang, Cheng Li, Junzhang Tian
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Nutrition & Dietetics
Ziyi Li, Liangzhi Wu, Junguo Zhang, Xin Huang, Lehana Thabane, Guowei Li
Summary: The study found no significant effect of vitamin D supplementation on the risk of breast cancer or mammography density. It suggests that previous observational studies might have overestimated the protective effect of vitamin D on breast cancer risk.
FRONTIERS IN NUTRITION
(2021)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)