期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 115, 期 15, 页码 E3388-E3397出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1722452115
关键词
aging; S-nitrosylation; GSNOR; mitochondria; mitophagy
资金
- Danish Cancer Society [KBVU R146-A9414, R146-A9364]
- Associazione Italiano per la Ricerca sul Cancro (AIRC) [IG20719, IG2017, 20464]
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) Grants MIUR/Fondo per gli Investimenti della Ricerca di Base (FIRB) [AUTOMED-RBAP11Z3YA, PRIN-20157ATSLF_009]
- NIH [P01HL075443, R01GM099921, R01HL126900, P01HL128192]
- Bjarne Saxhof Foundation
- NovoNordisk [22544]
- Fondazione Umberto Veronesi fellowship
S-nitrosylation, a prototypic redox-based posttranslational modification, is frequently dysregulated in disease. S-nitrosoglutathione reductase (GSNOR) regulates protein S-nitrosylation by functioning as a protein denitrosylase. Deficiency of GSNOR results in tumorigenesis and disrupts cellular homeostasis broadly, including metabolic, cardiovascular, and immune function. Here, we demonstrate that GSNOR expression decreases in primary cells undergoing senescence, as well as in mice and humans during their life span. In stark contrast, exceptionally long-lived individuals maintain GSNOR levels. We also show that GSNOR deficiency promotes mitochondrial nitrosative stress, including excessive S-nitrosylation of Drp1 and Parkin, thereby impairing mitochondria! dynamics and mitophagy. Our findings implicate GSNOR in mammalian longevity, suggest a molecular link between protein S-nitrosylation and mitochondria quality control in aging, and provide a redox-based perspective on aging with direct therapeutic implications.
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