期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 115, 期 26, 页码 E5980-E5989出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1720564115
关键词
CD8(+) T cells; NKp30; innate; IL-15; anti-tumor
资金
- DKFZ Light Microscopy Facility
- German Federal Ministry of Research and Education (BMBF) [01ZX1307B]
- Deutsche Krebshilfe Grants [70112233, 110442]
CD8(+) T cells are considered prototypical cells of adaptive immunity. Here, we uncovered a distinct CD8(+) T cell population expressing the activating natural killer (NK) receptor NKp30 in the peripheral blood of healthy individuals. We revealed that IL-15 could de novo induce NKp30 expression in a population of CD8(+) T cells and drive their differentiation toward a broad innate transcriptional landscape. The adaptor Fc epsilon RI gamma was concomitantly induced and was shown to be crucial to enable NKp30 cell-surface expression and function in CD8(+) T cells. Fc epsilon RI gamma de novo expression required promoter demethylation and was accompanied by acquisition of the signaling molecule Syk and the innate transcription factor PLZF. IL-15-induced NKp30(+) CD8(+) T cells exhibited high NK-like antitumor activity in vitro and were able to synergize with T cell receptor signaling. Importantly, this population potently controlled tumor growth in a preclinical xenograft mouse model. Our study, while blurring the borders between innate and adaptive immunity, reveals a unique NKp30(+)Fc epsilon Rl gamma(+)CD8(+) T cell population with high antitumor therapeutic potential.
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