Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure

PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts

(2017) Silja Meier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial InfarctionNovelty and Significance

(2016) Christiane Vettel et al.   CIRCULATION RESEARCH

Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness

(2016) Dan Li et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular Physiology of Membrane Guanylyl Cyclase Receptors

(2016) Michaela Kuhn   PHYSIOLOGICAL REVIEWS

Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth

(2016) Sandeep Dhayade et al.   Cell Reports

The Concise Guide to PHARMACOLOGY 2015/16: Overview

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

(2015) Anna Zoccarato et al.   CIRCULATION RESEARCH

A Molecular Screen Identifies Cardiac Myosin Binding Protein-C as a Protein Kinase G I Alpha Substrate

(2015) Robrecht Thoonen et al.   Circulation-Heart Failure

Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction

(2015) Mihai Gheorghiade et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

(2015) Dong I. Lee et al.   NATURE

Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis

(2014) R S Baliga et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Phosphodiesterase 2 Augments cGMP and cAMP Signaling to Ameliorate Pulmonary Hypertension

(2014) Kristen J. Bubb et al.   CIRCULATION

Endothelial C-type natriuretic peptide maintains vascular homeostasis

(2014) Amie J. Moyes et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium

(2014) Lise Román Moltzau et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

(2014) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis

(2014) E. Patrucco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological Ventricular Remodeling

(2013) Min Xie et al.   CIRCULATION

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction

(2013) Margaret M. Redfield et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Volume overload induces differential spatiotemporal regulation of myocardial soluble guanylyl cyclase in eccentric hypertrophy and heart failure

(2013) Yuchuan Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes

(2013) Hind Mehel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Protein Kinase G Iα Inhibits Pressure Overload–Induced Cardiac Remodeling and Is Required for the Cardioprotective Effect of Sildenafil In Vivo

(2013) Robert M. Blanton et al.   Journal of the American Heart Association

Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling

(2012) Manling Zhang et al.   CIRCULATION

cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes

(2011) Alessandra Stangherlin et al.   CIRCULATION RESEARCH

Pressure-Overload–Induced Subcellular Relocalization/Oxidation of Soluble Guanylyl Cyclase in the Heart Modulates Enzyme Stimulation

(2011) Emily J. Tsai et al.   CIRCULATION RESEARCH

Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I

(2011) Stefan Frantz et al.   EUROPEAN HEART JOURNAL

Sub-cellular targeting of constitutive NOS in health and disease

(2011) Yin Hua Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PDE5 Inhibition With Sildenafil Improves Left Ventricular Diastolic Function, Cardiac Geometry, and Clinical Status in Patients With Stable Systolic Heart Failure

(2010) Marco Guazzi et al.   Circulation-Heart Failure

Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

(2010) Viktor Lakics et al.   NEUROPHARMACOLOGY

Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II

(2010) Walid Mokni et al.   PLoS One

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes

(2010) R. Lukowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice

(2009) Peter Pokreisz et al.   CIRCULATION

Role of Ca 2+ /Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy

(2009) Clint L. Miller et al.   CIRCULATION RESEARCH

cGMP-dependent protein kinase II and aldosterone secretion

(2009) Beate Spießberger et al.   FEBS Journal

β-Adrenergic stimulation and myocardial function in the failing heart

(2009) Ali El-Armouche et al.   HEART FAILURE REVIEWS

Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation

(2009) Norimichi Koitabashi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

cGMP-Hydrolytic Activity and Its Inhibition by Sildenafil in Normal and Failing Human and Mouse Myocardium

(2009) F. Vandeput et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO• and beyond

(2009) Rebecca H. Ritchie et al.   PHARMACOLOGY & THERAPEUTICS

Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics

(2009) Emily J. Tsai et al.   PHARMACOLOGY & THERAPEUTICS

Sildenafil therapy in secondary pulmonary hypertension: Is there benefit in prolonged use?

(2009) T.H. Chapman et al.   VASCULAR PHARMACOLOGY

Pharmacologic Therapies Across the Continuum of Left Ventricular Dysfunction

(2008) William T. Abraham et al.   AMERICAN JOURNAL OF CARDIOLOGY

Gender-specific hypertension and responsiveness to nitric oxide in sGCα1 knockout mice

(2008) Emmanuel S. Buys et al.   CARDIOVASCULAR RESEARCH

Regulator of G-Protein Signaling Subtype 4 Mediates Antihypertrophic Effect of Locally Secreted Natriuretic Peptides in the Heart

(2008) Takeshi Tokudome et al.   CIRCULATION