Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes

Development and retention of a primordial moonlighting pathway of protein modification in the absence of selection presents a puzzle

(2018) Xinyun Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoic acid metabolism and mitochondrial redox regulation

(2017) Ashley Solmonson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

News and views

(2017) Sander M. Houten   JOURNAL OF INHERITED METABOLIC DISEASE

MoonProt 2.0: an expansion and update of the moonlighting proteins database

(2017) Chang Chen et al.   NUCLEIC ACIDS RESEARCH

Mis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell death

(2017) Emanuele Bernardinelli et al.   PLoS One

Expression and Activity of the BioH Esterase of Biotin Synthesis is Independent of Genome Context

(2017) Xinyun Cao et al.   Scientific Reports

MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder

(2016) Gali Heimer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus influenzae

(2016) Jie Shi et al.   BIOCHEMISTRY

Differential diagnosis of lipoic acid synthesis defects

(2016) Frederic Tort et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway

(2016) John E. Cronan   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Staphylococcus aureus Tissue Infection During Sepsis Is Supported by Differential Use of Bacterial or Host-Derived Lipoic Acid

(2016) Azul Zorzoli et al.   PLoS Pathogens

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

TheStreptomyces coelicolorLipoate-protein Ligase Is a Circularly Permuted Version of theEscherichia coliEnzyme Composed of Discrete Interacting Domains

(2015) Xinyun Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A series of medium and high copy number arabinose-inducible Escherichia coli expression vectors compatible with pBR322 and pACYC184

(2015) Vandana Chakravartty et al.   PLASMID

Why study moonlighting proteins?

(2015) Constance J. Jeffery   Frontiers in Genetics

Gene duplication and the evolution of moonlighting proteins

(2015) Adriana Espinosa-Cantú et al.   Frontiers in Genetics

An evolutionary perspective on protein moonlighting

(2014) Shelley D. Copley   BIOCHEMICAL SOCIETY TRANSACTIONS

Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy

(2014) Nor Azimah Abdul Azize et al.   JOURNAL OF HUMAN GENETICS

Lipoic acid biosynthesis defects

(2014) Johannes A. Mayr et al.   JOURNAL OF INHERITED METABOLIC DISEASE

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5

(2013) Peter R. Baker et al.   BRAIN

Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes

(2013) Frederic Tort et al.   HUMAN MOLECULAR GENETICS

Comprehensive Identification of Proteins from MALDI Imaging

(2013) Stefan K. Maier et al.   MOLECULAR & CELLULAR PROTEOMICS

Essential nontranslational functions of tRNA synthetases

(2013) Min Guo et al.   Nature Chemical Biology

Analysis Tool Web Services from the EMBL-EBI

(2013) Hamish McWilliam et al.   NUCLEIC ACIDS RESEARCH

Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase

(2013) Yohan Soreze et al.   Orphanet Journal of Rare Diseases

The role of theSaccharomyces cerevisiaelipoate protein ligase homologue, Lip3, in lipoic acid synthesis

(2013) Fatemah A. Hermes et al.   YEAST

Moonlighting is mainstream: Paradigm adjustment required

(2012) Shelley D. Copley   BIOESSAYS

Comparative Proteomic Analysis of Eleven Common Cell Lines Reveals Ubiquitous but Varying Expression of Most Proteins

(2012) Tamar Geiger et al.   MOLECULAR & CELLULAR PROTEOMICS

Compromised Mitochondrial Fatty Acid Synthesis in Transgenic Mice Results in Defective Protein Lipoylation and Energy Disequilibrium

(2012) Stuart Smith et al.   PLoS One

Lipoic Acid Synthetase Deficiency Causes Neonatal-Onset Epilepsy, Defective Mitochondrial Energy Metabolism, and Glycine Elevation

(2011) Johannes A. Mayr et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Toward a Systems Biology Perspective on Enzyme Evolution

(2011) Shelley D. Copley   JOURNAL OF BIOLOGICAL CHEMISTRY

A Complex Lipoate Utilization Pathway inListeria monocytogenes

(2011) Quin H. Christensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein-Protein Interactions in Assembly of Lipoic Acid on the 2-Oxoacid Dehydrogenases of Aerobic Metabolism

(2011) Bachar H. Hassan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian ACSF3 Protein Is a Malonyl-CoA Synthetase That Supplies the Chain Extender Units for Mitochondrial Fatty Acid Synthesis

(2011) Andrzej Witkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis

(2011) Quin H. Christensen et al.   MOLECULAR MICROBIOLOGY

A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis

(2011) Natalia Martin et al.   MOLECULAR MICROBIOLOGY

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Lipoic Acid Synthesis: A New Family of Octanoyltransferases Generally Annotated as Lipoate Protein Ligases

(2010) Quin H. Christensen et al.   BIOCHEMISTRY

Lipoic Acid Metabolism in Microbial Pathogens

(2010) M. D. Spalding et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Scavenging of Cytosolic Octanoic Acid by Mutant LplA Lipoate Ligases Allows Growth of Escherichia coli Strains Lacking the LipB Octanoyltransferase of Lipoic Acid Synthesis

(2009) F. A. M. Hermes et al.   JOURNAL OF BACTERIOLOGY

Down-regulation of Mitochondrial Acyl Carrier Protein in Mammalian Cells Compromises Protein Lipoylation and Respiratory Complex I and Results in Cell Death

(2009) Dejiang Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TheThermoplasma acidophilumLplA-LplB Complex Defines a New Class of Bipartite Lipoate-protein Ligases

(2009) Quin H. Christensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pfam protein families database

(2009) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Promiscuous protein biotinylation by Escherichia coli biotin protein ligase

(2004) Eunjoo Choi-Rhee et al.   PROTEIN SCIENCE