Numerical investigation of particle deposition in a triple bifurcation airway due to gravitational sedimentation and inertial impaction

Focusing on the particle deposition due to gravitational sedimentation and inertial impaction, the transport and deposition of micron particles with various diameters (i.e.,1 to 7 mu m) have been simulated in a triple bifurcation airway at flow rates of 15 to 120 L/min. The airway configurations for generation 11 to generation 14 are determined by matching the Stokes number Stand the sedimentation parameter gamma (Particuology, 2016, 28:102-113). Air flow distributions, local deposition patterns, and deposition efficiencies are compared between simulations with and without gravity. The results suggest that minimum deposition efficiency exists for large particles indicating the change of dominant deposition mechanism between sedimentation and impaction. Sedimentation governed particle deposition is also observed for small particles. A revised correlation for predicting DE as a function of Stokes number and sedimentation parameter is proposed for 5.78 x 10(-4) <0.226 and 1.54 x 10(-4)<0.06. These findings could be utilized to design the drug particle property and inhalation waveform for the high-efficiency pulmonary drug delivery. (C) 2017 Elsevier B.V. All rights reserved.