Article
Nutrition & Dietetics
Frank E. E. van Boven, Nicolette J. T. Arends, Aline B. B. Sprikkelman, Joyce A. M. Emons, Astrid I. I. Hendriks, Marloes van Splunter, Marco W. J. Schreurs, Severina Terlouw, Roy Gerth van Wijk, Harry J. J. Wichers, Huub F. J. Savelkoul, R. J. Joost van Neerven, Kasper A. Hettinga, Nicolette W. W. de Jong
Summary: Accelerating tolerance induction to cow's milk can reduce the burden of cow's milk allergy. This study aimed to investigate the tolerance induction of a novel heated cow milk protein in children with cow's milk allergy. Results showed that 73% of children in the treatment group had a negative food challenge test, compared to 57% in the control group.
Article
Nutrition & Dietetics
Nicolette W. de Jong, Marloes E. van Splunter, Joyce A. M. Emons, Kasper A. Hettinga, Roy Gerth van Wijk, Harry J. Wichers, Huub F. J. Savelkoul, Aline B. Sprikkelman, R. J. Joost van Neerven, Liu Liu, Gerbrich van der Meulen, Irene Herpertz, Yvonne C. M. Duijvestijn, Mijke Breukels, Marianne I. Brouwer, Jaap Schilperoord, Olga van Doorn, Berber Vlieg-Boerstra, Jochum van den Berg, Linette Pellis, Severina Terlouw, Astrid I. Hendriks, Marco W. J. Schreurs, Frank E. van Boven, Nicolette J. T. Arends
Summary: The aim of this study was to evaluate the safety and tolerability of a new heated cow's milk protein product in cow's milk allergic children. The results showed that 72% of the children tolerated the product, while some experienced adverse events. Skin prick tests and specific IgE levels may predict the tolerability of the product.
Review
Nutrition & Dietetics
Laurien Ulfman, Angela Tsuang, Aline B. Sprikkelman, Anne Goh, R. J. Joost van Neerven
Summary: The incidence of food allergies has increased worldwide in the past 20 years. Early introduction of allergenic foods has been shown to reduce the risk of allergies, but less is known about the introduction of cow's milk. Recent studies suggest that early introduction of cow's-milk-based formulas with intact milk proteins can reduce the risk of cow's milk allergy, while very early introduction followed by discontinuation may increase the risk.
Article
Allergy
Sebastian A. Jensen, Alessandro Fiocchi, Ton Baars, Galateja Jordakieva, Anna Nowak-Wegrzyn, Isabella Pali-Scholl, Stefano Passanisi, Christina L. Pranger, Franziska Roth-Walter, Kristiina Takkinen, Amal H. Assa'ad, Carina Venter, Erika Jensen-Jarolim
Summary: The immunopathogenesis of cow's milk protein allergy is affected by industrial processing, leading to structural changes and increased allergenicity of milk allergens. Unprocessed fresh milk contains tolerogenic factors that are impaired by industrial processing.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Review
Pediatrics
Khaled Saad, Anas Elgenidy, Mostafa Atef, Mostafa K. Abdelsattar, Mahmoud Al-Ashwah, Emad M. Hammad, Faisal-Alkhateeb Ahmed, Amir Aboelgheet, Mohamed Shawky Elfarargy, Ahmad M. Ali, Amira H. El-Ashry, Hamad Ghaleb Dailah, Amira Elhoufey, Samaher F. Taha
Summary: This study assessed the ability of Cow's Milk-related Symptom Score (CoMiss) in screening cow's milk protein allergy (CMPA). The results showed that CoMiss may be a promising symptom score in CMPA awareness and a useful tool in monitoring the response to a cow's milk-free diet.
PEDIATRIC RESEARCH
(2023)
Review
Nutrition & Dietetics
Caoimhe Cronin, Yukta Ramesh, Carlo De Pieri, Roberto Velasco, Juan Trujillo
Summary: IgE-mediated cow's milk protein allergy (CMPA) is a common food allergy in early childhood. The management methods of avoidance, the milk ladder, and oral immunotherapy (OIT) are all effective in promoting tolerance, but further research is needed to compare their safety and effectiveness.
Review
Nutrition & Dietetics
Katerina Bajerova, Silvia Salvatore, Christophe Dupont, Philippe Eigenmann, Mikael Kuitunen, Rosan Meyer, Carmen Ribes-Koninckx, Raanan Shamir, Hania Szajewska, Yvan Vandenplas
Summary: This review summarizes the current evidence on the Cow's Milk-related Symptom Score (CoMiSS), which is a clinical tool used to assess symptoms possibly related to cow's milk intake. It found that CoMiSS can be used to predict the response to a cow's milk-free diet in infants and diagnose cow's milk allergy in children.
Review
Food Science & Technology
Sabine Geiselhart, Aleksandra Podzhilkova, Karin Hoffmann-Sommergruber
Summary: Cow's milk is an essential part of our diet but can also trigger immune-mediated diseases. Allergens in cow's milk have been identified, but processing methods can impact their immunogenicity.
Article
Allergy
Rita Nocerino, Serena Coppola, Laura Carucci, Anna Fiorenza de Giovanni di Santa Severina, Franca Oglio, Roberta de Michele, Ilaria di Sessa, Antonio Masino, Giorgio Bedogni, Roberto Berni Canani
Summary: This study investigated the tolerability and immune tolerance acquisition rate in infants with cow's milk allergy (CMA) who were treated with amino acid-based formula (AAF) and then switched to EHCF + LGG, a formula containing the probiotic Lacticaseibacillus rhamnosus GG. The results showed that after 12 months of treatment, the immune tolerance acquisition rate to cow milk proteins was higher in the EHCF + LGG group compared to the AAF group.
Article
Food Science & Technology
Natalia Zofia Maryniak, Mette Halkjaer Stage, Anne-Sofie Ravn Ballegaard, Ana Isabel Sancho, Egon Bech Hansen, Katrine Lindholm Bogh
Summary: Currently, there are no specific recommendations for using any particular infant formula to prevent cow's milk allergy. There is increasing interest in alternative infant formulas made from milk proteins from animals other than cows, but their ability to prevent cow's milk allergy has not been studied.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pediatrics
Emilia Vassilopoulou, Colleen McMilin, Carina Venter
Summary: The process of reintroducing food allergens into a person's diet, known as a food allergen ladder, is increasingly used in clinical practice. This study aimed to develop a Mediterranean milk ladder based on the Mediterranean eating pattern, with specific recipes and protein content for each step. The accuracy of measuring milk protein concentrations was affected by the presence of other ingredients. The proposed Mediterranean milk ladder focuses on healthy eating and food acceptability across age groups.
Article
Allergy
Yvonne M. d'Art, Lisa Forristal, Aideen M. Byrne, John Fitzsimons, Ronald van Ree, Audrey DunnGalvin, Jonathan O'Brien Hourihane
Summary: The study shows that introducing baked milk after the diagnosis of cow's milk allergy can safely and effectively improve infants' tolerance to milk. Maternal anxiety is also found to be associated with infants' progress on the milk ladder.
Review
Pediatrics
Rohan Malik, Sanjeevani Kaul
Summary: Cow's milk allergy is an immunological reaction to milk protein, commonly occurring in infants under 1 year of age. The disease can be IgE or non-IgE mediated, with symptoms involving multiple organ systems. The gold standard for diagnosis is a double-blind placebo-controlled oral challenge. Treatment involves eliminating the allergen and using specialized formula.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Lucia Liotti, Annamaria Bianchi, Paolo Bottau, Silvia Caimmi, Giuseppe Crisafulli, Fabrizio Franceschini, Francesca Mori, Claudia Paglialunga, Francesca Saretta, Carlo Caffarelli
Summary: The COVID-19 pandemic is the most challenging global health crisis of our times, with vaccination playing a key role in controlling the current situation. While there is debate about the safety of COVID-19 vaccines for allergic patients, current data suggest that even patients with allergies to cow's milk or other foods should receive the vaccine in a setting with treatments for anaphylactic reactions and under medical supervision.
Review
Nutrition & Dietetics
Dafni Moriki, Maria Pilar Francino, Despoina Koumpagioti, Barbara Boutopoulou, Jose Angel Rufian-Henares, Kostas N. Priftis, Konstantinos Douros
Summary: Cow's milk allergy is the most common food allergy in infancy and early childhood, with recent increases in allergy rates possibly linked to limited microbial exposure and changes in gut microbiome composition. The gut microbiome plays a crucial role in the host's lifelong health.
Review
Biochemistry & Molecular Biology
Pawel Bryniarski, Katarzyna Nazimek, Janusz Marcinkiewicz
Summary: This review article focuses on the immunomodulatory properties of angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) in hypertensive patients. ACEI and ARB can inhibit proinflammatory cytokine secretion, decrease expression of adhesion molecules, and normalize CRP concentration, thus exerting immune regulatory effects. This has significant importance in the treatment of patients with underlying chronic inflammatory responses and may also benefit those with comorbidities like metabolic syndrome, allergies, or autoimmune disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Martyna Cieslik, Katarzyna Nazimek, Krzysztof Bryniarski
Summary: The possibility of orally delivering extracellular vesicles (EVs) and their functional cargos has gained research attention. EVs from various sources have emerged as a platform for miRNA and drug delivery, inducing immune effects after oral administration. This review summarizes research findings on the biological/therapeutic activity of orally administered EVs and their role in cross-species and cross-kingdom signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Dominik Felkle, Mateusz Jarczynski, Konrad Kaleta, Katarzyna Zieba, Katarzyna Nazimek
Summary: Hypertension is the leading preventable risk factor for stroke and coronary artery disease. Despite the widespread usage of antihypertensive drugs, it is important to understand their effects on immune system function and the underlying mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Krzysztof Bryniarski, Katarzyna Nazimek
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Dominik Felkle, Katarzyna Zieba, Konrad Kaleta, Julia Czaja, Amanda Zyzdorf, Wiktoria Sobocinska, Mateusz Jarczynski, Krzysztof Bryniarski, Katarzyna Nazimek
Summary: Macrophage overactivation is considered the main cause of severe complications in COVID-19. Concerns have been raised about the safety of ACE inhibitors due to their increased expression of ACE2, but analysis of patients treated with ACE inhibitors does not support these concerns. Instead, ACE inhibitors have been found to have beneficial effects on macrophages, including anti-inflammatory activation and reducing the risk of severe disease and complications.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Martyna Cieslik, Krzysztof Bryniarski, Katarzyna Nazimek
Summary: Currently, extracellular vesicles (EVs) are considered promising for cell-free therapies, but their effectiveness is limited by rapid clearance by the mononuclear phagocyte system (MPS). Strategies to avoid EV elimination are necessary for their clinical application. On the other hand, dysfunctional MPS is associated with immune-related pathologies, which could potentially be reversed by EVs through modulating macrophage phenotype or regulating antigen presentation by dendritic cells. Targeting EVs to MPS macrophages for replication and repackaging of their molecules into new vesicle subtype can enable specific targeting to desired cells. Further research on MPS-EV interactions is needed for the therapeutic use of EVs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Martyna Cieslik, Krzysztof Bryniarski, Katarzyna Nazimek
Summary: This article discusses the presence of microRNAs (miRNAs) in common foods and their potential use as therapeutics. Oral administration of miRNAs is considered promising due to their protection from gastrointestinal enzymes and ability to affect gastric and intestinal cells. Additionally, miRNAs may have cross-species or cross-kingdom communication and can potentially treat various diseases.
AIMS ALLERGY AND IMMUNOLOGY
(2023)
Article
Immunology
Iwona Filipczak-Bryniarska, Katarzyna Nazimek, Bernadeta Nowak, Paulina Skalska, Martyna Cieslik, Angelika Fedor, Magdalena Gebicka, Gabriela Kruk, Joanna Pelka-Zakielarz, Michael Kozlowski, Krzysztof Bryniarski
Summary: This study investigated the immune effects induced by tramadol alone or in combination with acetaminophen or dexketoprofen in healthy mice. The results suggest that these drugs slightly reduce the inflammatory reaction of macrophages but do not impair their ability to activate adaptive immune responses. Some combinations also enhance humoral and cellular immune responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pawel Bryniarski, Katarzyna Nazimek, Janusz Marcinkiewicz
Summary: This study demonstrates the effects of diuretics and combination drugs on the function of macrophages. These drugs increase the production of ROS, reduce the formation of NO, and inhibit the secretion of IL-12. They also reduce the activity of contact hypersensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Immunology
Katarzyna Nazimek, Philip W. Askenase, Krzysztof Bryniarski
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
Katarzyna Nazimek, Pawel Bryniarski, Hanna Twardowska, Krzysztof Bryniarski
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Katarzyna Nazimek
Summary: Current efforts are focused on developing strategies to activate long-lasting antigen-specific immune tolerance in allergic and autoimmune diseases through genetic modulation of cell functions using miRNA-based treatments. The role of miR-150 in immune responses is of special interest due to its involvement in signaling cascades orchestrating both innate and adaptive immune mechanisms. MiR-150 is considered a master regulator of immunity in mammals and its potential therapeutic applications are being explored in the pathogenesis and complications of allergic and autoimmune disorders.
AIMS ALLERGY AND IMMUNOLOGY
(2021)