Article
Medicine, General & Internal
Vera Maraspin, Petra Bogovic, Katarina Ogrinc, Tereza Rojko, Eva Ruzic-Sabljic, Andrej Kastrin, Klemen Strle, Gary P. Wormser, Franc Strle
Summary: The study compared US and European patients with early Lyme borreliosis, finding that US patients with a positive blood culture were less likely to recall a tick bite, more likely to have multiple EM lesions, regional lymphadenopathy, and other symptoms compared to European patients. These differences do not support the hypothesis that spirochetemia at the time of presentation is the reason for differences between US and European patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Marek Asman, Joanna Witecka, Jan Korbecki, Krzysztof Solarz
Summary: Ixodes ricinus is the main vector in Europe for Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum, and Babesia microti. A study conducted in Wolinski National Park showed a high potential human risk of exposure to tick-borne infection with Babesia microti, and low risks of infection with Borrelia garinii and Anaplasma phagocytophilum in the area.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Victor Eiferman, Guillaume Le Guenno, Nathalie Boiret-Dupre, Bertrand Barres, Lea Luciani, Pierre Edouard Fournier
Summary: We present a case of an atypical Borrelia garinii infection in an immunocompromised patient, initially suspected as a transformation of follicular lymphoma into high-grade lymphoma. Direct observation of spirochetes on a peripheral blood smear confirmed the diagnosis using molecular methods. The clinical presentation and diagnosis in this patient contrast with previously reported cases in immunocompromised individuals.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Annukka Pietikainen, Mia Astrand, Julia Cuellar, Otto Glader, Heli Elovaara, Meri Rouhiainen, Jemiina Salo, Tomomi Furihata, Tiina A. Salminen, Jukka Hytonen
Summary: This study found that the binding of Lyme borreliae to human brain microvascular endothelial cells is related to the pathogenesis of neuroborreliosis, suggesting that lysine residues in decorin binding proteins play a crucial role in this process.
MOLECULAR MICROBIOLOGY
(2021)
Article
Immunology
Natalie Rudenko, Maryna Golovchenko, Ales Horak, Libor Grubhoffer, Emmanuel F. Mongodin, Claire M. Fraser, Weigang Qiu, Benjamin J. Luft, Richard G. Morgan, Sherwood R. Casjens, Steven E. Schutzer
Summary: Lyme disease is primarily caused by Borrelia burgdorferi sensu lato, but a new strain called B. garinii has been found to cause Lyme disease in islands off the coast of Canada. We isolated and sequenced the whole genome of a B. garinii isolate from a cotton mouse in South Carolina, USA, and identified another B. garinii isolate from the same repository. Phylogenetic analysis showed that these isolates are not associated with the previously described B. garinii isolates from Canada.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
K. Ogrinc, V. Maraspin, L. Lusa, T. Cerar Kisek, E. Ruzic-Sabljic, F. Strle
Summary: Background information on patients with acrodermatitis chronica atrophicans (ACA) is limited. The study assessed clinical and microbiological characteristics of ACA patients at a single medical center, finding that the majority of patients had skin lesions on extremities, showing reddish-blue discoloration, swelling, and thinning of the skin. Most skin samples isolated Borreliae, with the majority being Borrelia afzelii.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Infectious Diseases
Nannet D. Fabri, Hans Heesterbeek, Joris P. G. M. Cromsigt, Frauke Ecke, Hein Sprong, Lonneke Nijhuis, Tim R. Hofmeester, Nienke Hartemink
Summary: In many parts of the northern hemisphere, different species of deer, small mammals, and birds coexist and their composition can strongly influence the outbreak potential of tick-borne pathogens. This study investigates how the abundance and composition of vertebrate communities affect the basic reproduction number R0 of tick-borne pathogens, and shows that species composition plays a substantial role in the outbreak potential of tick-borne diseases.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Multidisciplinary Sciences
Choon Mee Kim, So Young Park, Dong-Min Kim, Jung Wook Park, Jae Keun Chung
Summary: Lyme disease is a tick-borne infection caused by the Borrelia burgdorferi sensu lato complex, and the detection rate of Borrelia in wild rodents has been rarely studied. In South Korea, a study found the presence of Borrelia infection in wild rodents, with the highest rate in the heart and spleen. This study also suggests that besides B. garinii and B. afzelii, B. burgdorferi sensu stricto may also contribute to Lyme disease in South Korea.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Maryna Golovchenko, Jakub Opelka, Marie Vancova, Hana Sehadova, Veronika Kralikova, Martin Dobias, Milan Raska, Michal Krupka, Kristyna Sloupenska, Natalie Rudenko
Summary: Lyme disease spirochetes have the ability to invade immune-privileged sites in the host and employ diverse strategies to evade the host immune system and maintain chronic infection. A case of dual infection with two species of spirochetes in the brain tissue of a Lyme disease patient is reported, with different distribution patterns and atypical morphology observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Marta F. Silva, Ana L. Pereira, Maria J. Fraqueza, Goncalo Pereira, Luisa Mateus, Luis Lopes-da-Costa, Elisabete Silva
Summary: This study evaluated the virulence potential and biovar characteristics of Cfv isolates, revealing the absence of putative VF genes in 92% of isolates and the invalidation of parA gene for diagnostic purposes. Three novel MLST sequence types were identified. In addition, WGS identified antimicrobial resistance-related genes and segregated the Cfv and Cfvi strains into different clusters based on SNP and accessory protein families analysis.
Article
Microbiology
Alejandra Wu-Chuang, Lourdes Mateos-Hernandez, Apolline Maitre, Ryan O. M. Rego, Radek Sima, Stefania Porcelli, Sabine Rakotobe, Angelique Foucault-Simonin, Sara Moutailler, Vaidas Palinauskas, Juste Azelyte, Ladislav Simo, Dasiel Obregon, Alejandro Cabezas-Cruz
Summary: Research has found that infection with Borrelia afzelii causes changes to the microbiota composition, diversity, and structure in ticks. Anti-microbiota vaccines can alter the tick microbiota's ability to be infected by Borrelia and decrease the pathogen's load. Network analysis is a suitable tool for identifying properties of the vector microbiota associated with infection-refractory states.
Article
Infectious Diseases
Tingting Li, Yuxian Xin, Dongxia Liu, Jingrong Sun, Jingwei Li, Ying Zhang, Jie Feng
Summary: Lyme disease is a tick-transmitted infection caused by bacteria that can develop resistance to antibiotics, making it important to find new pharmaceuticals for more effective treatments.
INFECTIOUS MICROBES & DISEASES
(2023)
Article
Entomology
Gilian van Duijvendijk, Inge Krijger, Marloes van Schaijk, Manoj Fonville, Gerrit Gort, Hein Sprong, Willem Takken
Summary: This study investigated the seasonal infection risk of Ixodes ricinus ticks and their rodent hosts, as well as the infection rates of Borrelia burgdorferi sensu lato and Borrelia miyamotoi. The results showed that the heterogeneity of environmental and host factors influenced the transmission of these two different Borrelia species, with a stronger effect on horizontally transmitted B. burgdorferi than on vertically transmitted B. miyamotoi.
EXPERIMENTAL AND APPLIED ACAROLOGY
(2022)
Article
Immunology
Yelena Losev, Mor Rubinstein, Israel Nissan, Paz Haviv, Yohi Barsky, Martha Volinsky, Gefen Bar-Giora, Tamara Zouher, Mazal Hamawi, Gal Zizelski Valenci, Ina Kutikov, Hasia Kaidar Shwartz, Zeev Dveyrin, Daniel Chemtob, Efrat Rorman
Summary: According to the World Health Organization, tuberculosis is the second leading cause of death from infectious disease globally. This study provides an overview of newly diagnosed tuberculosis patients in Israel in 2021, highlighting the need for ongoing surveillance and effective treatment strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Entomology
Seung-Ho Lee, Sung-Tae Chong, Heung-Chul Kim, Terry A. Klein, Kyungmin Park, Jingyeong Lee, Jeong-Ah Kim, Won-Keun Kim, Jin-Won Song
Summary: This study focused on detecting Borrelia species from ticks collected at U.S. Army Garrison Humphreys in South Korea and found that Ixodes nipponensis was the most commonly collected species. Molecular analysis revealed the prevalence and molecular characteristics of Borrelia species in the region, providing valuable insights into Lyme disease risk factors.
JOURNAL OF MEDICAL ENTOMOLOGY
(2022)
Article
Microbiology
Sebastien Bontemps-Gallo, Edwige Madec, Jean-Marie Lacroix
ENVIRONMENTAL MICROBIOLOGY
(2015)
Article
Immunology
Kevin Quintard, Amelie Dewitte, Angeline Reboul, Edwige Madec, Sebastien Bontemps-Gallo, Jacqueline Dondeyne, Michael Marceau, Michel Simonet, Jean-Marie Lacroix, Florent Sebbane
INFECTION AND IMMUNITY
(2015)
Review
Environmental Sciences
Sebastien Bontemps-Gallo, Jean-Marie Lacroix
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2015)
Article
Multidisciplinary Sciences
Sebastien Bontemps-Gallo, Edwige Madec, Catherine Robbe-Masselot, Erika Souche, Jacqueline Dondeyne, Jean-Marie Lacroix
SCIENTIFIC REPORTS
(2016)
Article
Microbiology
Sebastien Bontemps-Gallo, Kevin Lawrence, Frank C. Gherardini
Article
Biochemistry & Molecular Biology
Sebastien Bontemps-Gallo, Kevin A. Lawrence, Crystal L. Richards, Frank C. Gherardini
MOLECULAR MICROBIOLOGY
(2018)
Article
Microbiology
Sebastien Bontemps-Gallo, Charlotte Gaviard, Crystal L. Richards, Takfarinas Kentache, Sandra J. Raffel, Kevin A. Lawrence, Joseph C. Schindler, Joseph Lovelace, Daniel P. Dulebohn, Robert G. Cluss, Julie Hardouin, Frank C. Gherardini
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Microbiology
Marine Caby, Sebastien Bontemps-Gallo, Peggy Gruau, Brigitte Defrue, Edwige Madecl, Jean-Marie Lacroix
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Sebastien Bontemps-Gallo, Marion Fernandez, Amelie Dewitte, Etienne Raphael, Frank C. Gherardini, Pradel Elizabeth, Lionel Koch, Fabrice Biot, Angeline Reboul, Florent Sebbane
MOLECULAR MICROBIOLOGY
(2019)
Article
Immunology
Catherine Daniel, Amalie Dewitte, Sabine Poiret, Michael Marceau, Michel Simonet, Laure Marceau, Guillaume Descombes, Denise Boutillier, Nadia Bennaceur, Sebastian Bontemps-Gallo, Nadine Lemaitre, Florent Sebbane
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Ecology
Typhanie Bouvenot, Amelie Dewitte, Nadia Bennaceur, Elizabeth Pradel, Francois Pierre, Sebastien Bontemps-Gallo, Florent Sebbane
Summary: The study reveals the transmission pathway of Yersinia pestis in fleas and the role of lipoylation of metabolic enzymes. It also demonstrates that spatial and temporal factors determine the bacterium's strategies for utilizing lipoylation during an infection.
Review
Microbiology
Sebastien Bontemps-Gallo, Jean-Marie Lacroix, Florent Sebbane
Summary: Yersinia pestis, the plague agent, spreads mainly among mammalian hosts and fleas, perceiving and responding to cues in both environments, with osmolarity being a key parameter. The bacterium lives in a tightly regulated environment in mammalian hosts, while facing osmolarity fluctuations in flea guts. It has mechanisms to sense and adapt to these osmolarity changes.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Amelie Dewitte, Elisabeth Werkmeister, Francois Pierre, Florent Sebbane, Sebastien Bontemps-Gallo
Summary: The causative agent of plague, Yersinia pestis, circulates primarily among rodent populations and their fleas. By obstructing the flea's proventriculus, Y. pestis can maintain transmission to mammalian hosts. Consolidating a bacteria-entrapping mass within the proventriculus increases the likelihood of flea blockage and allows Y. pestis to persist in flea populations for a longer duration. Targeting bacterial mass consolidation could significantly reduce the transmission of Y. pestis by fleas.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Chemistry, Analytical
Blandine Rougemont, Sebastien Bontemps Gallo, Sophie Ayciriex, Romain Carriere, Hubert Hondermarck, Jean Marie Lacroix, J. C. Yves Le Blanc, Jerome Lemoine
ANALYTICAL CHEMISTRY
(2017)