Article
Biotechnology & Applied Microbiology
Taner Sar, Murat Ozturk, Benjamin C. Stark, Meltem Yesilcimen Akbas
Summary: This study investigated improvements in desulfurization of DBT and DBTS by Paenibacillus strains through immobilization and nanoparticle coating, showing promising results for enhancing biodesulfurization efficiency.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
T. Sar, Y. Chen, Y. Bai, B. Liu, P. Agarwal, B. C. Stark, M. Y. Akbas
Summary: The enhancement of desulfurization activities of Paenibacillus strains 32O-W and 32O-Y was investigated using different sulfur sources, with the co-culture of strains showing the best growth under specific conditions.
LETTERS IN APPLIED MICROBIOLOGY
(2021)
Article
Environmental Sciences
Tae Yoon Kim, Sang-Hyo Lee, Seung-Yop Lee
Summary: The two isolated Haematococcus strains in this study showed morphological, genomic, and bioaccumulation characteristics related to the genus Haematococcus. They efficiently removed radioactive cesium in low-level contaminated water within 48 hours. This cesium-accumulation mechanism is associated with potassium replacement in thick cell walls and astaxanthin accumulation.
ENVIRONMENTAL RESEARCH
(2021)
Article
Chemistry, Physical
Chawan Saiwan Othman, Yousif Mustafa Salih, Luqman Omar Hamasalih, Hozan Jalal Saleem
Summary: The adsorption desulfurization of dibenzothiophene (DBT) in model oil was investigated using four different adsorbers: activated charcoal, activated charcoal loaded with monometallic manganese, activated charcoal loaded with monometallic copper, and activated charcoal loaded with bimetallic manganese and copper. The adsorber with bimetallic manganese and copper showed the highest desulfurization efficiency. In a fixed-bed system, this adsorber performed the best, with only a 34% decrease in efficiency after 300 minutes. The adsorption process of DBT on this adsorber followed Pseudo-Second-Order kinetics and the Langmuir adsorption isotherm model. When used to desulfurize high-sulfur commercial diesel fuel, DBT was completely removed and the total sulfur content decreased by 99% to 16 ppm.
REACTION KINETICS MECHANISMS AND CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Lin Li, Zhongpeng Zhao, Xiaolan Yang, Zhongyi Su, Wendong Li, Shaolong Chen, Lu Wang, Ting Sun, Chen Du, Ziyi Li, Zeqian Yang, Min Li, Tiecheng Wang, Ying Wang, Yubo Fan, Hui Wang, Jing Zhang
Summary: A linear B-cell epitope screening strategy was developed to identify a hotspot region in the Spike protein and a monomeric peptide vaccine (Epitope25) was developed. The vaccine induced specific and dose-dependent IgG antibody responses in mice and showed neutralizing activity against SARS-CoV-2.
Article
Plant Sciences
Jeong Hun Cho, Myoung Chong Song, Yonghee Lee, Seung-Taek Noh, Dae-Ok Kim, Chan-Su Rha
Summary: Korean Red Ginseng is a valuable source of bioactive substances. In the process of extracting saponins from red ginseng, previously unidentified molecules were discovered in the water-soluble component-rich fraction, and their efficacy was confirmed.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Chemistry, Applied
Krzysztof Buksa, Magdalena Kowalczyk, Jakub Boreczek
Summary: This study found that the use of exopolysaccharides (EPS) produced by newly isolated lactic acid bacteria strains can limit the formation of high molecular weight resistant starch in wheat starch pastes. These EPS can be efficiently produced in sourdough, improving the properties of sourdough bread.
Article
Plant Sciences
Olumayowa M. Olowe, Michael D. Asemoloye, Odunayo J. Olawuyi
Summary: This study focused on characterizing common Fusarium strains causing ear rot disease of maize and the potential control using arbuscular mycorrhiza. The most susceptible maize variety T2LCOMP4 showed better suppression of ear rot disease when treated with two arbuscular mycorrhizal fungi, with a higher control effect observed for Glomus clarum compared to G. deserticola.
Article
Biotechnology & Applied Microbiology
Naeun Oh, Jaehoon Lee, Hyewon Kim, Mijin Kwon, Jeongmin Seo, Sangho Roh
Summary: This study identified three new strains of Lactobacillus plantarum and investigated the antiobesogenic and antidiabetic effects of their extracts. The results showed that one of the extracts (L14) significantly reduced adipogenic differentiation and insulin resistance in vitro, suggesting its potential therapeutic use for obesity-associated metabolic disorders.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Atala B. Jena, Rashmi R. Samal, Kanchan Kumari, Jyotsnarani Pradhan, Gagan B. N. Chainy, Umakanta Subudhi, Satyanarayan Pal, Jagnehswar Dandapat
Summary: This study reveals the inhibitory effect of para-benzoquinone on the structure and function of bovine liver catalase. The binding affinity between para-benzoquinone and BLC varies depending on the nature of buffers used. The altered secondary structure of BLC induced by para-benzoquinone results in compromised enzyme activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Rashmi R. Samal, Kanchan Kumari, Yashaswinee Sahoo, Sandip K. Mishra, Umakanta Subudhi
Summary: The study demonstrates the protective role of the anti-malarial drug Artemisinin (ART) on the activity of catalase enzyme in bovine liver. Molecular docking studies indicate specific binding of ART on the enzyme through the heme group interface. The findings suggest that ART may serve as a potential therapeutic drug for diseases associated with reduced catalase activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Bineeth Baral, Juhi Dutta, Umakanta Subudhi
Summary: Branched DNA (bDNA) nanostructures interact with circulating protein BSA and cellular enzyme BLC through hydrogen bonding and van der Waals interaction. The negative free energy observed in ITC indicates a spontaneous reaction for BLC-bDNA interaction, and the presence of bDNA does not affect the structural stability and secondary conformation of proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biology
Salwa Naushin, Viren Sardana, Rajat Ujjainiya, Nitin Bhatheja, Rintu Kutum, Akash Kumar Bhaskar, Shalini Pradhan, Satyartha Prakash, Raju Khan, Birendra Singh Rawat, Karthik Bharadwaj Tallapaka, Mahesh Anumalla, Giriraj Ratan Chandak, Amit Lahiri, Susanta Kar, Shrikant Ramesh Mulay, Madhav Nilakanth Mugale, Mrigank Srivastava, Shaziya Khan, Anjali Srivastava, Bhawana Tomar, Murugan Veerapandian, Ganesh Venkatachalam, Selvamani Raja Vijayakumar, Ajay Agarwal, Dinesh Gupta, Prakash M. Halami, Muthukumar Serva Peddha, Gopinath M. Sundaram, Ravindra P. Veeranna, Anirban Pal, Vinay Kumar Agarwal, Anil Ku Maurya, Ranvijay Kumar Singh, Ashok Kumar Raman, Suresh Kumar Anandasadagopan, Parimala Karuppanan, Subramanian Venkatesan, Harish Kumar Sardana, Anamika Kothari, Rishabh Jain, Anupama Thakur, Devendra Singh Parihar, Anas Saifi, Jasleen Kaur, Virendra Kumar, Avinash Mishra, Iranna Gogeri, Geethavani Rayasam, Praveen Singh, Rahul Chakraborty, Gaura Chaturvedi, Pinreddy Karunakar, Rohit Yadav, Sunanda Singhmar, Dayanidhi Singh, Sharmistha Sarkar, Purbasha Bhattacharya, Sundaram Acharya, Vandana Singh, Shweta Verma, Drishti Soni, Surabhi Seth, Sakshi Vashisht, Sarita Thakran, Firdaus Fatima, Akash Pratap Singh, Akanksha Sharma, Babita Sharma, Manikandan Subramanian, Yogendra S. Padwad, Vipin Hallan, Vikram Patial, Damanpreet Singh, Narendra Vijay Tripude, Partha Chakrabarti, Sujay Krishna Maity, Dipyaman Ganguly, Jit Sarkar, Sistla Ramakrishna, Balthu Narender Kumar, Kiran A. Kumar, Sumit G. Gandhi, Piyush Singh Jamwal, Rekha Chouhan, Vijay Lakshmi Jamwal, Nitika Kapoor, Debashish Ghosh, Ghanshyam Thakkar, Umakanta Subudhi, Pradip Sen, Saumya Ray Chaudhury, Rashmi Kumar, Pawan Gupta, Amit Tuli, Deepak Sharma, Rajesh P. Ringe, D. Amarnarayan, Mahesh Kulkarni, Dhansekaran Shanmugam, Mahesh S. Dharne, Sayed G. Dastager, Rakesh Joshi, Amita P. Patil, Sachin N. Mahajan, Abujunaid Habib Khan, Vasudev Wagh, Rakesh Kumar Yadav, Ajinkya Khilari, Mayuri Bhadange, Arvindkumar H. Chaurasiya, Shabda E. Kulsange, Krishna Khairnar, Shilpa Paranjape, Jatin Kalita, Narahari G. Sastry, Tridip Phukan, Prasenjit Manna, Wahengbam Romi, Pankaj Bharali, Dibyajyoti Ozah, Ravi Kumar Sahu, Elapavalooru Vssk Babu, Rajeev Sukumaran, Aiswarya R. Nair, Prajeesh Kooloth Valappil, Anoop Puthiyamadam, Adarsh Velayudhanpillai, Kalpana Chodankar, Samir Damare, Yennapu Madhavi, Ved Varun Aggarwal, Sumit Dahiya, Anurag Agrawal, Debasis Dash, Shantanu Sengupta
Summary: The Council of Scientific and Industrial Research in India conducted a serosurvey in August and September 2020 to understand the spread of SARS-CoV2 and found that some individuals may be infected with the virus even without symptoms. Personal factors such as high-exposure work, use of public transport, non-smoking, non-vegetarian diet, and blood type B are associated with higher odds of seropositivity.
Article
Biology
Prateek Singh, Rajat Ujjainiya, Satyartha Prakash, Salwa Naushin, Viren Sardana, Nitin Bhatheja, Ajay Pratap Singh, Joydeb Barman, Kartik Kumar, Saurabh Gayali, Raju Khan, Birendra Singh Rawat, Karthik Bharadwaj Tallapaka, Mahesh Anumalla, Amit Lahiri, Susanta Kar, Vivek Bhosale, Mrigank Srivastava, Madhav Nilakanth Mugale, C. P. Pandey, Shaziya Khan, Shivani Katiyar, Desh Raj, Sharmeen Ishteyaque, Sonu Khanka, Ankita Rani, Promila, Jyotsna Sharma, Anuradha Seth, Mukul Dutta, Nishant Saurabh, Murugan Veerapandian, Ganesh Venkatachalam, Deepak Bansal, Dinesh Gupta, Prakash M. Halami, Muthukumar Serva Peddha, Ravindra P. Veeranna, Anirban Pal, Ranvijay Kumar Singh, Suresh Kumar Anandasadagopan, Parimala Karuppanan, Syed Nasar Rahman, Gopika Selvakumar, Subramanian Venkatesan, Malay Kumar Karmakar, Harish Kumar Sardana, Anamika Kothari, Devendra Singh Parihar, Anupma Thakur, Anas Saifi, Naman Gupta, Yogita Singh, Ritu Reddu, Rizul Gautam, Anuj Mishra, Avinash Mishra, Iranna Gogeri, Geethavani Rayasam, Yogendra Padwad, Vikram Patial, Vipin Hallan, Damanpreet Singh, Narendra Tirpude, Partha Chakrabarti, Sujay Krishna Maity, Dipyaman Ganguly, Ramakrishna Sistla, Narender Kumar Balthu, Kiran A. Kumar, Siva Ranjith, B. Vijay Kumar, Piyush Singh Jamwal, Anshu Wali, Sajad Ahmed, Rekha Chouhan, Sumit G. Gandhi, Nancy Sharma, Garima Rai, Faisal Irshad, Vijay Lakshmi Jamwal, Masroor Ahmad Paddar, Sameer Ullah Khan, Fayaz Malik, Debashish Ghosh, Ghanshyam Thakkar, S. K. Barik, Prabhanshu Tripathi, Yatendra Kumar Satija, Sneha Mohanty, Md Tauseef Khan, Umakanta Subudhi, Pradip Sen, Rashmi Kumar, Anshu Bhardwaj, Pawan Gupta, Deepak Sharma, Amit Tuli, Saumya Ray Chaudhuri, Srinivasan Krishnamurthi, L. Prakash, Ch Rao, B. N. Singh, Arvindkumar Chaurasiya, Meera Chaurasiya, Mayuri Bhadange, Bhagyashree Likhitkar, Sharada Mohite, Yogita Patil, Mahesh Kulkarni, Rakesh Joshi, Vaibhav Pandya, Sachin Mahajan, Amita Patil, Rachel Samson, Tejas Vare, Mahesh Dharne, Ashok Giri, Sachin Mahajan, Shilpa Paranjape, G. Narahari Sastry, Jatin Kalita, Tridip Phukan, Prasenjit Manna, Wahengbam Romi, Pankaj Bharali, Dibyajyoti Ozah, RaviKumar Sahu, Prachurjya Dutta, Moirangthem Goutam Singh, Gayatri Gogoi, Yasmin Begam Tapadar, Elapavalooru V. S. S. K. Babu, Rajeev K. Sukumaran, Aishwarya R. Nair, Anoop Puthiyamadam, Prajeesh Kooloth Valappil, Adrash Velayudhan Pillai Prasannakumari, Kalpana Chodankar, Samir Damare, Ved Varun Agrawal, Kumardeep Chaudhary, Anurag Agrawal, Shantanu Sengupta, Debasis Dash
Summary: Data science has played a crucial role in the COVID-19 pandemic response, and this study demonstrates how a statistical and machine learning approach can be used to discriminate between SARS-CoV-2 infection and immune response to a whole virion vaccine. By analyzing serial antibody data and incorporating an ensemble ML model, the researchers were able to accurately classify potential infections and validate their findings through neutralization assays. This study highlights the importance of real-world vaccine effectiveness assessments for whole virion vaccines.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Physical
Indrani Mishra, Subrata Majumder, Shalik Ram Joshi, U. Subudhi, Shikha Varma
Summary: This study investigates the adsorption of DNA on SiOx and nanostructured-SiOx substrates to understand their binding behavior. Experimental results show that DNA binding on nanostructured-SiOx introduces chemical states like Si...O...N and Si...N, while only Si...O...N state is observed on SiOx surface. DFT results suggest that the linkage appears to occur via electrostatic interaction and charge transfer from the substrate to the nitrogen bases of DNA.
Article
Biochemistry & Molecular Biology
Madhabi M. Bhanjadeo, Partha S. Nial, Chakkarai Sathyaseelan, Ajit K. Singh, Juhi Dutta, Thenmalarchelvi Rathinavelan, Umakanta Subudhi
Summary: The transition from right-handed to left-handed DNA not only plays a controlling role in gene expression switching but also has importance in nanomechanical device design. This study demonstrates that LaCl3 can induce controlled and reversible B-Z transition in short repeat sequences, providing insights into the molecular mechanism of this transition. The binding of LaCl3 to the phosphate backbone of Z-DNA is strong, resulting in the irreversible thermal melting of LaCl3-induced Z-DNA. These findings suggest that LaCl3 can be used as an inducer of left-handed DNA in other short oligonucleotide sequences.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Atala B. Jena, Suvasmita Rath, Umakanta Subudhi, Jagneshwar Dandapat
Summary: This study investigates the structural and functional alterations of catalase induced by benzo-a-pyrene (BaP). The results show that BaP treatment leads to reduced catalase activity, changes in secondary conformation, and binding near the active site of catalase. These findings provide mechanistic insights into the compromised conformation and catalytic activity of catalase caused by BaP exposure.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Oncology
Avishek Kar, Kanchan Kumari, Sandip K. Mishra, Umakanta Subudhi
Summary: In this study, self-assembled branched DNA (bDNA) nanostructures containing oncogenic miRNAs were transfected to cells, resulting in the downregulation of tumor suppressor protein FOXO1 expression. The bDNA structures selectively bind to mRNA and inhibit translation, and also downregulate the downstream gene expression of FOXO1. This finding suggests the potential of using bDNA structures to downregulate tumor suppressor proteins and promote cell proliferation, which may help identify early-phase markers of cancer.
Article
Biochemistry & Molecular Biology
Atala B. Jena, Rashmi R. Samal, Jagneshwar Dandapat, Umakanta Subudhi
Summary: Biological macromolecules, such as proteins, nucleic acids, carbohydrates and lipids, are essential for biochemical and molecular processes. This study investigates the interaction between the benzene metabolite para-benzoquinone (BQ) and nucleic acids (B-DNA) and human serum albumin (HSA). The results show that BQ affects the binding ability and structure of HSA, potentially impacting plasma osmotic pressure and the binding of molecules. BQ also interacts with the GC region of B-DNA, potentially inducing mutagenicity and oxidative damage.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Rashmi R. Samal, Kajal Sundaray, Kiran D. Tulsiyan, Sumit Saha, Gagan B. N. Chainy, Umakanta Subudhi
Summary: This study explored the inhibitory effect of PTU on BLC activity and the protective role of CUR. The results showed that PTU reduced BLC activity by changing its conformation and zeta potential, while CUR restored the secondary conformation and protected BLC activity. CUR inhibited the time-induced reduction in BLC activity and its protection was concentration-dependent. The binding affinity between CUR and BLC was stronger than BLC-PTU complex. This study provides detailed insights into the molecular mechanism of PTU-induced reduction in BLC activity and its alleviation by CUR, suggesting the potential therapeutic applications of CUR.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Moumita Gourai, Ashok K. Nayak, Partha S. Nial, Bijaylaxmi Satpathy, Rajashree Bhuyan, Saroj K. Singh, Umakanta Subudhi
Summary: Anthropogenic activities contribute to fluoride contamination in groundwater, posing a threat to public health. This study focuses on the production of biochars from Moringa oleifera using thermal plasma processing and their effectiveness in adsorbing fluoride in synthetic and contaminated groundwater samples. The biochars exhibit high porosity, amorphous structure, and large exposed surface area, making them efficient for fluoride adsorption. The results demonstrate that Moringa oleifera biochars can effectively remove fluoride from groundwater samples, with a removal efficiency of over 85% using 1 g biochar for 100 mL water containing 4 ppm fluoride.
Article
Medicine, Research & Experimental
Bineeth Baral, Bijayananda Panigrahi, Avishek Kar, Kiran Tulsiyan, Uday Suryakant, Dindyal Mandal, Umakanta Subudhi
Summary: This study demonstrates the use of self-assembled linear peptides as delivery agents for functional bDNA nanomaterials in mammalian cells. The W4R4 peptides show excellent internalization of antisense bDNAs and significantly suppress the expression of VEGF.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Chemistry, Multidisciplinary
Kanchan Kumari, Avishek Kar, Ashok K. Nayak, Sandip K. Mishra, Umakanta Subudhi
Summary: Sulfatase enzymes catalyze sulfate ester hydrolysis, deficiency of which leads to biomolecule accumulation and various disorders. Posttranslational modification of estrone sulfatase is critical, with SUMF1 being the key factor. SUMF1 expression affects patient survival in breast cancer, potentially regulated by miRNAs, suggesting therapeutic potential in endocrine-related malignancies.
Review
Multidisciplinary Sciences
Kanchan Kumari, Gagan B. N. Chainy, Umakanta Subudhi
