Molecular effect of an OPTN common variant associated to Paget's disease of bone

Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone

(2018) Iris A.L. Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

(2016) Karolina Slowicka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The TBK1-binding domain of optineurin promotes type I interferon responses

(2016) Netra Pal Meena et al.   FEBS LETTERS

Cellular Functions of Optineurin in Health and Disease

(2016) Karolina Slowicka et al.   TRENDS IN IMMUNOLOGY

Optimizing methodologies for PCR-based DNA methylation analysis

(2016) Hernán G. Hernández et al.   BIOTECHNIQUES

Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism

(2015) Wen-Chuan Shen et al.   Autophagy

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMEM25Is a Candidate Biomarker Methylated and Down-Regulated in Colorectal Cancer

(2013) Sonja Hrašovec et al.   DISEASE MARKERS

Optineurin Insufficiency Impairs IRF3 but Not NF- B Activation in Immune Cells

(2013) I. Munitic et al.   JOURNAL OF IMMUNOLOGY

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Toward an integrative view of Optineurin functions

(2012) David Kachaner et al.   CELL CYCLE

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons

(2011) K. Iwamoto et al.   GENOME RESEARCH

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β

(2011) Catherine E. Gleason et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optineurin in neurodegenerative diseases

(2011) Tenshi Osawa et al.   NEUROPATHOLOGY

DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing

(2011) Fabienne Brenet et al.   PLoS One

Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

(2011) Ananthamurthy Nagabhushana et al.   PLoS One

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Frequency and characteristics of familial aggregation of paget's disease of bone

(2010) A.A. Morales-Piga et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone

(2010) Omar M E Albagha et al.   NATURE GENETICS

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-κB by Human T-Lymphotropic Virus Type 1 Tax Protein

(2009) Chloé Journo et al.   PLoS Pathogens

Prevalence of Pelvic Paget's Disease of Bone in the United States

(2006) R. D. Altman et al.   JOURNAL OF BONE AND MINERAL RESEARCH