Article
Biochemistry & Molecular Biology
Uiju Cho, Yeoun-Eun Sung, Min-Sik Kim, Youn-Soo Lee
Summary: This study indicates that pretreatment PLR is an independent predictor of disease-specific survival (DSS) and progression-free survival (PFS) in oral squamous cell carcinoma (OSCC) patients, with a stronger predictive effect in male patients, stage III/IV patients, and patients with lymph node metastasis.
Article
Multidisciplinary Sciences
Li Kunshan, Liu Yuanhang, Sun Jieming, Qiu Junping, Wang Wenjing, Qiu Yongle
Summary: This study identified specific prognostic biomarkers for OSCC, including ENSTa and KIF19. ENSTa inhibits the progression of OSCC by regulating the KIF19 gene, and these two biomarkers could be suggested as novel biomarkers for OSCC.
Article
Oncology
Lorenzo Fernandes Moca Trevisani, Isabelle Fernandes Kulcsar, Marco Aurelio Vamondes Kulcsar, Rogerio Aparecido Dedivitis, Luiz Paulo Kowalski, Leandro Luongo Matos
Summary: Oral squamous cell carcinoma (OSCC) is a significant public health concern, but there is a lack of well-established indices that specifically relate to the patient and indicate a worse prognosis. This study assessed the prognostic impact of hematological indices in OSCC patients and found that the red cell distribution width (RDW) is a reliable parameter for assessing overall survival.
Article
Immunology
Marta Ruiz-Ranz, Paloma Lequerica-Fernandez, Tania Rodriguez-Santamarta, Faustino J. Suarez-Sanchez, Rosa M. Lopez-Pintor, Juana M. Garcia-Pedrero, Juan C. de Vicente
Summary: This study investigated the prognostic significance of preoperative inflammatory markers in patients with oral squamous cell carcinoma (OSCC) and their correlations with tumor microenvironment (TME) infiltrates. The results showed that preoperative NLR, SII, and LMR may serve as valuable systemic markers to predict OSCC patient survival, with NLR emerging as an independent predictor of poor overall survival. Strong correlations were also observed between systemic inflammatory markers and the local stromal infiltration of lymphocytes in the TME.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lei Yang, Qiqiong Zhang, Qiuye Yang
Summary: This study reveals the role of KDM3A in regulating proliferation and invasion of OSCC cells by eliminating H3K9me2 to upregulate DCLK1 expression levels.
Article
Biotechnology & Applied Microbiology
Liru Zhang, Huanju Li, Yongle Qiu, Yuanhang Liu, Xin Liu, Wenjing Wang
Summary: Novel prognostic biomarkers regulated by super enhancers in OSCC were identified, among which AHCY, KCMF1, and MANBAL were recognized as key markers regulated by TFDP1.
Article
Oncology
Qingkun Jiang, Danfeng Xue, Fanzhe Shi, Jiaxuan Qiu
Summary: By analyzing gene sequencing and clinicopathological data, this study identified autophagy-related lncRNAs in patients with OSCC/OPSCC and established a signature that can serve as an independent prognostic indicator, promoting research on targeted diagnosis and treatment for these patients.
Review
Dentistry, Oral Surgery & Medicine
Fernanda Weber Mello, Pedro Vitali Kammer, Carolina Amalia Barcellos Silva, Eric Kenneth Parkinson, Luis Monteiro, Saman Warnakulasuriya, Elena Riet Correa Rivero
Summary: Among the identified studies, there is evidence suggesting that PDPN expression may be associated with poorer survival rates in OSCC, particularly in relation to lymph node involvement, higher histopathological grade, and advanced clinical stages. Further exploration is needed to confirm the potential utility of PDPN as a prognostic marker for OSCC.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Review
Oncology
Jerry Polesel, Anna Menegaldo, Giancarlo Tirelli, Vittorio Giacomarra, Roberto Guerrieri, Lorena Baboci, Mariateresa Casarotto, Valentina Lupato, Giuseppe Fanetti, Paolo Boscolo-Rizzo, Elisabetta Fratta
Summary: The expression of PD-L1 in OPSCC is associated with improved survival, particularly benefiting HPV-positive OPSCC patients compared to their negative counterparts. PD-L1 may serve as a valuable biomarker to stratify prognosis in OPSCC alongside HPV status.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yajun Shen, Haoyue Xu, Lingyu Li, Yunping Lu, Min Zhang, Xin Huang, Xiaofei Tang
Summary: This study found that PRDX1 is the only highly expressed member of the PRDX family in OSCC that affects patient prognosis, and its expression is closely related to tumor characteristics. GSEA results showed that the high expression of PRDX1 is involved in multiple cancer-related functions and signaling pathways.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Takuya Yoshimura, Hajime Suzuki, Hirotaka Takayama, Shotaro Higashi, Yuka Hirano, Masahiro Tezuka, Takayuki Ishida, Kiyohide Ishihata, Marie Amitani, Haruka Amitani, Yasuhiro Nishi, Yasunori Nakamura, Yasushi Imamura, Etsuro Nozoe, Akio Inui, Norifumi Nakamura
Summary: Retrospective evaluation of multiple indicators in blood samples revealed that low PNI was associated with shorter overall survival and disease-free survival, while women were associated with shorter disease-free survival.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Linfeng Zhang, Mingfei Wang, Wenhao Ren, Shaoming Li, Keqian Zhi, Ling Gao, Jingjing Zheng
Summary: This systematic review comprehensively evaluates the clinicopathological and prognostic value of dysregulated expression of circRNAs in OSCC, and suggests that circRNAs may serve as candidate biomarkers for the prognosis and clinicopathology of OSCC.
Article
Oncology
Christian Doll, Carolin Bestendonk, Kilian Kreutzer, Konrad Neumann, Anne Pohrt, Irena Trzpis, Steffen Koerdt, Steffen Dommerich, Max Heiland, Jan-Dirk Raguse, Korinna Joehrens
Summary: Although ERa expression is rare in OSCC, it is associated with a dramatic decrease in overall survival in male patients. Further studies are needed to confirm these results and evaluate the exact mechanism underlying this observation. Therefore, ERa-positive OSCC patients might benefit from an ER-based therapeutic (adjuvant) approach in the future.
Article
Biochemistry & Molecular Biology
Leonor Delgado, Paula Brilhante-Simoes, Fernanda Garcez, Luis Monteiro, Isabel Pires, Justina Prada
Summary: p-mTOR and p-S6 proteins are commonly expressed in canine oral squamous cell carcinoma (OSCC), and p-S6 expression is correlated with poor cancer-specific survival (CSS) in dogs with OSCC.
Article
Biochemistry & Molecular Biology
Shi-Long Zhang, Lei Chen, Lin-Lin Bu, Zi-Li Yu, Si-Rui Ma
Summary: This study investigated the expression and clinical significance of SEC61G in oral squamous cell carcinoma (OSCC). The findings showed a significant correlation between SEC61G expression and clinicopathological characteristics, as well as a worse prognosis in OSCC patients. Moreover, SEC61G expression was also associated with decreased immune infiltration in OSCC patients.
Article
Otorhinolaryngology
Marcos Custodio, Bruno Tavares Sedassari, Albina Altemani, Maria Fernanda Setubal Destro Rodrigues, Fabio Daumas Nunes, Suzana Cantanhede Orsini Machado de Sousa
Summary: Secretory carcinoma of salivary gland origin (SCsg) exhibits distinct expression patterns for mTOR signaling molecules, with only eIF4E showing high expression. This suggests the existence of alternative signaling pathways beyond Akt and mTOR in this type of tumors.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Genetics & Heredity
Corina Lesseur, Aida Ferreiro-Iglesias, James D. McKay, Yohan Bosse, Mattias Johansson, Valerie Gaborieau, Maria Teresa Landi, David C. Christiani, Neil C. Caporaso, Stig E. Bojesen, Christopher I. Amos, Sanjay Shete, Geoffrey Liu, Gadi Rennert, Demetrios Albanes, Melinda C. Aldrich, Adonina Tardon, Chu Chen, Liloglou Triantafillos, John K. Field, Marion Dawn Teare, Lambertus A. Kiemeney, Brenda Diergaarde, Robert L. Ferris, Shanbeh Zienolddiny, Stephen Lam, Andrew F. Olshan, Mark C. Weissler, Martin Lacko, Angela Risch, Heike Bickeboller, Andy R. Ness, Steve Thomas, Loic Le Marchand, Matthew B. Schabath, Victor Wunsch-Filho, Eloiza H. Tajara, Angeline S. Andrew, Gary M. Clifford, Philip Lazarus, Kjell Grankvist, Mikael Johansson, Susanne Arnold, Olle Melander, Hans Brunnstrom, Stefania Boccia, Gabriella Cadoni, Wim Timens, Ma'en Obeidat, Xiangjun Xiao, Richard S. Houlston, Rayjean J. Hung, Paul Brennan
Summary: Squamous cell carcinomas (SqCC) of the aerodigestive tract share common etiological risk factors and genetic susceptibility. A meta-analysis of GWAS data identified novel and pleiotropic risk variants, highlighting the importance of cross-cancer analyses. Gene-based association and gene set enrichment revealed SqCC-related genes involved in DNA damage and epigenetic regulation pathways. The study suggests overlap in genetic factors influencing aerodigestive SqCC risk in European populations.
Article
Behavioral Sciences
Aline Ribeiro Borcoi, Suzanny Oliveira Mendes, Ivana Alece Arantes Moreno, Joaquim Gasparini dos Santos, Flavia Vitorino Freitas, Julia Assis Pinheiro, Mayara Mota de Oliveira, Wagner Miranda Barbosa, Juliana Kruger Arpini, Anderson Barros Archanjo, Andre Willian Hollais, Cinthia Vidal Monteiro da Silva Couto, Camila Vieira Chagas David, Barbara Risse Quaioto, Bruna Pereira Sorroche, Iuri Drumond Louro, Lidia Maria Rebolho Batista Arantes, Adriana Madeira Alvares-da-Silva
Summary: This study aimed to investigate the relationship between socioeconomic stressors, epigenetic changes in the NR3C1-1F gene, and depressive symptoms, suggesting that FNiS may lead to depressive symptoms and that NR3C1-1F DNA methylation can act as a mediator in this relationship.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Article
Genetics & Heredity
Mark Gormley, James Yarmolinsky, Tom Dudding, Kimberley Burrows, Richard M. Martin, Steven Thomas, Jessica Tyrrell, Paul Brennan, Miranda Pring, Stefania Boccia, Andrew F. Olshan, Brenda Diergaarde, Rayjean J. Hung, Geoffrey Liu, Danny Legge, Eloiza H. Tajara, Patricia Severino, Martin Lacko, Andrew R. Ness, George Davey Smith, Emma E. Vincent, Rebecca C. Richmond
Summary: The study found limited evidence that genetically-proxied LDL-C lowering through certain drug targets had a significant effect on the risk of oral and oropharyngeal cancer. However, genetic inhibition of PCSK9 increased the risk of cancer, while genetic variants in LDLR reduced the risk. Further replication of these findings is required to fully understand the mechanisms behind these associations.
Article
Dentistry, Oral Surgery & Medicine
Maria Fernanda Setubal Destro Rodrigues, Flavia Calo Aquino Xavier, Carina Duarte Esteves, Rebeca Barros Nascimento, Juliana Stephan Nobile, Patricia Severino, Rafael de Cicco, Tatiana Natasha Toporcov, Eloiza Helena Tajara, Fabio Daumas Nunes
Summary: The study investigated DNA copy number and methylation profile of homeobox genes in oral squamous cell carcinoma. The results showed that some genes were regulated by amplification or methylation, but no correlation with clinicopathological parameters or survival was observed.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Mark Gormley, Tom Dudding, Linda Kachuri, Kimberley Burrows, Amanda H. W. Chong, Richard M. Martin, Steven J. Thomas, Jessica Tyrrell, Andrew R. Ness, Paul Brennan, Marcus R. Munafo, Miranda Pring, Stefania Boccia, Andrew F. Olshan, Brenda Diergaarde, Rayjean J. Hung, Geoffrey Liu, Eloiza H. Tajara, Patricia Severino, Tatiana N. Toporcov, Martin Lacko, Tim Waterboer, Nicole Brenner, George Davey Smith, Emma E. Vincent, Rebecca C. Richmond
Summary: Evidence from the study suggests that genetic variants related to sexual behavior traits may have correlated pleiotropy, highlighting the importance of multivariable approaches and evidence triangulation in Mendelian randomization studies of complex behavioral traits.
Article
Dentistry, Oral Surgery & Medicine
Lucyene Miguita, Juliana Cristina de Souza, Victor Coutinho Bastos, Nubia Braga Pereira, Raphaela Alvarenga Braga de Freitas, Leticia Martins Guimaraes, Gleide Fernandes de Avelar, Luciana Oliveira Andrade, Walderez Ornelas Dutra, Fabio Daumas Nunes, Wagner Henriques Castro, Julio Cesar Tanos de Lacerda, Amanda Maria Sena Reis, Vanessa Fatima Bernardes, Marina Goncalves Diniz, Ricardo Santiago Gomez, Carolina Cavalieri Gomes
Summary: The study evaluated the mutational status of mononuclear cells and giant cells in CGCG, as well as the osteogenic potential of stromal cells. The results confirm that the signature mutations are restricted to stromal cells in CGCG, and these cells have the capacity to differentiate into osteoblasts.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Juliana Prado Gusson-Zanetoni, Julliene Stephanie Guaraldi Monteiro da Silva, Thais Bravo Picao, Laila Toniol Cardin, Janesly Prates, Stefanie Oliveira Sousa, Tiago Henrique, Sonia Maria Oliani, Eloiza Helena Tajara, Marcio Luis Andrade E Silva, Nayanne Larissa Cunha, Ana Carolina da Silva Gomes, Rosangela Silva Laurentiz, Flavia Cristina Rodrigues-Lisoni
Summary: The study evaluates the effects of Piper cubeba extract and lignans on head and neck cancer cells, showing inhibitory effects on proliferation and migration, low cytotoxicity and genotoxicity, possibly through altering gene and protein expression related to inflammatory processes. Lignans cubebin and methylcubebin exhibit greater antiproliferative, antimigratory, and genotoxic effects, suggesting potential for new therapeutic developments in head and neck cancer treatment.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Surgery
Andre Lopes, Evandro Sobroza de Mello, Rossana Veronica Mendoza Lopez, Paulo Cesar Leonardi, Ulysses Ribeiro Jr
Summary: This study aimed to standardize the histopathological evaluation of pseudomyxoma peritonei and identify the clinicopathological factors associated with survival. The results showed that histologic grades are associated with disease-free survival when CC0-1 cytoreduction is achieved, and higher preoperative CA19-9 levels are associated with poor overall survival. CC0-1 cytoreduction is the main determinant of longer survival.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Environmental Sciences
Celso Muller Bandeira, Adriana Avila Almeida, Monica Ghislaine Oliveira Alves, Maria Beatriz Nogueira Pascoal, Jose Francisco Sales Chagas, Morun Bernardino Neto, Patricia Pimentel de Barros, Fabio Daumas Nunes, Celina Faig Lima Carta, Janete Dias Almeida
Summary: This study found that the evaluation method based on questionnaires and gene expression tests can be used to assess the risk of developing oral cancer and revealed the correlation between tobacco use and alcohol consumption with oral cancer. Furthermore, the study emphasizes the importance of raising individuals' awareness of their degree of dependence and encouraging them to participate in cessation programs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sofia Bevilaqua de Castro, Lucyene Miguita, Maria Fernanda Setubal Destro Rodrigues, Emilia Maria Gomes Aguiar, Juliana Mota Siqueira, Nataly Harumi de Morais Takano, Marcos Custodio Neto da Silva, Kristianne Porta Santos Fernandes, Ana Paula Ligeiro de Oliveira, Fabio Daumas Nunes
Summary: This study aimed to understand the mechanisms by which SCC cells modulate the immune response by analyzing the influence of conditioned medium derived from SCC cell lines on immune cells. The results showed that the products derived from squamous cell carcinoma can promote an immunosuppressed environment by reducing cell viability, changing cytokine expression, and altering the cell immunoprofile.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Carina Domaneschi, Vanessa Juliana Gomes Carvalho, Bruno Munhoz Marotta, Norberto Nobuo Sugaya, Fabio Daumas Nunes, Camila de Barros Gallo
Summary: Burning mouth syndrome (BMS) is a condition characterized by painful symptoms of the oral mucosa. This study evaluated the gene expression of voltage-gated sodium channels in BMS patients. The results showed no significant difference in the gene expression of these channels between BMS patients and healthy control patients, suggesting the need for further research to understand the functionality of these channels in BMS.
BRAZILIAN ORAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Luana Pereira Cardoso, Stefanie Oliveira de Sousa, Juliana Prado Gusson-Zanetoni, Laura Luciana de Melo Moreira de Melo Moreira Silva, Barbara Maria Frigieri, Tiago Henrique, Eloiza Helena Tajara, Sonia Maria Oliani, Flavia Cristina Rodrigues-Lisoni
Summary: This study aimed to investigate the antitumor effect of piperine on cervical cancer and whether this effect is modulated by the cyclooxygenase 2 (PTGS2) pathway. The results showed that piperine reduces neoplastic progression-associated parameters and induces apoptosis. This action is modulated by the downregulation of the PTGS2 pathway.
Article
Oncology
Sara Socorro Faria, Diana Giannarelli, Vladmir Claudio Cordeiro de Lima, Sumadi Luckman Anwar, Chiara Casadei, Ugo De Giorgi, Gabriele Madonna, Paolo Antonio Ascierto, Rossana Veronica Mendoza Lopez, Roger Chammas, Mariaelena Capone
Summary: Breast cancer-related inflammation plays a critical role in tumor development, cancer progression, and patient prognosis. In this study, a prognostic model was established and validated to predict disease-free survival in early-stage breast cancer patients based on readily available baseline clinicopathological prognostic factors and preoperative blood count-derived lymphocyte ratios.
