Article
Medicine, General & Internal
Yuehui Su, Yiming Zhang, Mengjiao Zhou, Ruijin Zhang, Siang Chen, Lili Zhang, Hao Wang, Dongdong Zhang, Ting Zhang, Xinqiang Li, Chunyan Zhang, Bingjie Wang, Shuyu Yuan, Mengzhuo Zhang, Yingying Zhou, Lili Cao, Mengzhen Zhang, Jianjun Luo
Summary: Clear cell adenocarcinoma of the cervix (CCAC) is a rare type of cervical cancer that is not related to HPV. It is difficult to diagnose early and has a poor prognosis. This study analyzed the genetic alterations in patients with CCAC and identified CMTM5 as a shared mutated gene. The study also found that certain genes related to reproductive cancers had higher mutation rates in patients with CCAC. Pathway analysis showed that non-HPV cervical cancer has a weaker immune response compared to HPV-infected cervical cancer.
FRONTIERS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Dong Hyeok Kim, Hyunwoo Jin, Kyung Eun Lee
Summary: This study aimed to provide basic data on using urine samples for non-invasive cervical cancer screening. The results showed a high concordance of 93.3% between urine samples and cervical swabs, with a higher HPV infection rate in urine samples among young women. Therefore, urine samples are considered a valuable screening method for preventing cervical cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Marat Sultanov, Janine de Zeeuw, Jaap Koot, Jurjen van der Schans, Jogchum J. Beltman, Marlieke de Fouw, Marek Majdan, Martin Rusnak, Naheed Nazrul, Aminur Rahman, Carolyn Nakisige, Arathi P. Rao, Keerthana Prasad, Shyamala Guruvare, Regien Biesma, Marco Versluis, Geertruida H. de Bock, Jelle Stekelenburg
Summary: The PRESCRIP-TEC project aims to investigate the feasibility of using hrHPV self-testing as the primary screening method for cervical cancer in different settings. Through quantitative and qualitative research, the project aims to understand the impact of this screening method on uptake and coverage, as well as various determinants of successful implementation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yingjie Xv, Fajin Lv, Haoming Guo, Xiang Zhou, Hao Tan, Mingzhao Xiao, Yineng Zheng
Summary: Machine learning-based CT radiomics, combined with various feature selection algorithms, developed a model with promising predictive performance for differentiating between low- and high-nuclear grade of CCRCC. The combined model outperformed other models and provided effective noninvasive assessment for preoperative prediction of CCRCC nuclear grade.
INSIGHTS INTO IMAGING
(2021)
Article
Obstetrics & Gynecology
Neal M. Lonky, Lanfang Xu, Diane M. Da Silva, Juan C. Felix, Chun Chao
Summary: This study aimed to evaluate the risk of high-grade cervical lesion diagnosed through colposcopy in women with human papillomavirus vaccination compared to women without vaccination. The results showed that vaccination history did not significantly lower the odds of a cervical intraepithelial neoplasm grade 2+ diagnosis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Oncology
Fu Yin, Haijie Zhang, Anqi Qi, Zexuan Zhu, Liyang Yang, Ge Wen, Weixin Xie
Summary: By utilizing the differential network feature selection method and the maximum-entropy probability model, the study explored the feasibility of predicting the WHO/ISUP grade and PFS of ccRCC, finding that the NCP RFs model demonstrated good performance in the test set and could effectively predict the disease status.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Geeta S. Narayanan, M. S. Ganesh, Rishabh Kumar
Summary: This study aimed to compare the treatment response of cervical carcinoma patients infected with HPV 16 and HPV 18 under chemoradiation, showing that HPV 16 positivity leads to a higher complete response compared to HPV 18 positivity. Further HPV genotyping could potentially aid in stratifying cervical cancer patients for more effective therapeutic regimens.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Oncology
Hamideh Rashidian, Maryam Hadji, Mahin Gholipour, Ahmad Naghibzadeh-Tahami, Maryam Marzban, Elham Mohebbi, Roya Safari-Faramani, Mahdieh Bakhshi, Monireh Sadat Seyyedsalehi, Bayan Hosseini, Reza Alizadeh-Navaei, Habib Emami, Ali Akbar Haghdoost, Abbas Rezaianzadeh, Abdolvahab Moradi, Alireza Ansari-Moghaddam, Azim Nejatizadeh, Soodabeh ShahidSales, Alireza Rezvani, Mohammad Hasan Larizadeh, Farid Najafi, Hossein Poustchi, Mohammad Ali Mohagheghi, Paul Brennan, Elisabete Weiderpass, Joachim Schuz, Eero Pukkala, Neal D. Freedman, Paolo Boffetta, Reza Malekzadeh, Arash Etemadi, Afarin Rahimi-Movaghar, Farin Kamangar, Kazem Zendehdel
Summary: Opium use is strongly associated with an increased risk of lung cancer, particularly small cell carcinoma. Regular opium users have a 3.6-fold higher risk of developing lung cancer compared to non-users, with a dose-response relationship observed. Female opium users have a higher risk than male users. The risk is further increased for individuals who use both opium and tobacco.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Hilary A. Robbins, Karine Alcala, Elham Khodayari Moez, Florence Guida, Sera Thomas, Hana Zahed, Matthew T. Warkentin, Karl Smith-Byrne, Yonathan Brhane, David Muller, Xiaoshuang Feng, Demetrius Albanes, Melinda C. Aldrich, Alan A. Arslan, Julie Bassett, Christine D. Berg, Qiuyin Cai, Chu Chen, Michael P. A. Davies, Brenda Diergaarde, John K. Field, Neal D. Freedman, Wen-Yi Huang, Mikael Johansson, Michael Jones, Woon-Puay Koh, Stephen Lam, Qing Lan, Arnulf Langhammer, Linda M. Liao, Geoffrey Liu, Reza Malekzadeh, Roger L. Milne, Luis M. Montuenga, Thomas Rohan, Howard D. Sesso, Gianluca Severi, Mahdi Sheikh, Rashmi Sinha, Xiao-Ou Shu, Victoria L. Stevens, Martin C. Tammemaegi, Lesley F. Tinker, Kala Visvanathan, Ying Wang, Renwei Wang, Stephanie J. Weinstein, Emily White, David Wilson, Jian-Min Yuan, Xuehong Zhang, Wei Zheng, Christopher I. Amos, Paul Brennan, Mattias Johansson, Rayjean J. Hung
Summary: The INTEGRAL program aims to develop tools for optimizing LDCT lung cancer screening. It includes the Risk Biomarker and Nodule Malignancy projects, which investigate circulating protein markers for identifying individuals likely to benefit from screening and distinguishing benign versus malignant nodules. A total of 1161 and 1078 proteins were measured, and 21 proteins were selected for performance evaluation in the Risk Biomarker and Nodule Malignancy projects.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Oncology
Jian Yin, Neal D. Freedman, Yiwei Liu, Sanford M. M. Dawsey, Huan Yang, Philip R. R. Taylor, Liangyu Yin, Bin Liu, Jianfeng Cui, Jinhu Fan, Wen Chen, Youlin Qiao, Christian C. C. Abnet
Summary: This study found that serum insulin and HOMA-IR may be risk factors for the development of primary liver cancer (PLC) or chronic liver disease (CLD) death. In HBV-positive patients, glucose was also associated with an increased risk of these diseases.
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Jung Kim, Danielle M. Karyadi, Stephen W. Hartley, Bin Zhu, Mingyi Wang, Dongjing Wu, Lei Song, Gregory T. Armstrong, Smita Bhatia, Leslie L. Robison, Yutaka Yasui, Brian Carter, Joshua N. Sampson, Neal D. Freedman, Alisa M. Goldstein, Lisa Mirabello, Stephen J. Chanock, Lindsay M. Morton, Sharon A. Savage, Douglas R. Stewart
Summary: The use of publicly available sequencing datasets as controls in rare variant disease association studies can increase the risk of false-positive discoveries. This study systematically investigated the factors that contribute to false-positive discoveries using both public controls and datasets sequenced in their own laboratory. The results showed that using the same variant caller and filtering pipelines significantly reduced the inflation of test statistics. However, differences in library prep kits and sequencers as well as joint vs. separate variant-calling of cases and controls did not affect the false-positive rate. This highlights the risks associated with using public controls and suggests the potential of cloud-based computing to mitigate these issues.
Article
Multidisciplinary Sciences
Mitchell J. Machiela, Wen-Yi Huang, Wendy Wong, Sonja I. Berndt, Joshua Sampson, Jonas De Almeida, Mustapha Abubakar, Jada Hislop, Kai-Ling Chen, Casey Dagnall, Norma Diaz-Mayoral, Mary Ferrell, Michael Furr, Alex Gonzalez, Belynda Hicks, Aubrey K. Hubbard, Amy Hutchinson, Kevin Jiang, Kristine Jones, Jia Liu, Erikka Loftfield, Jennifer Loukissas, Jerome Mabie, Shannon Merkle, Eric Miller, Lori M. Minasian, Ellen Nordgren, Brian Park, Paul Pinsky, Thomas Riley, Lorena Sandoval, Neeraj Saxena, Aurelie Vogt, Jiahui Wang, Craig Williams, Patrick Wright, Meredith Yeager, Bin Zhu, Claire Zhu, Stephen J. Chanock, Montserrat Garcia-Closas, Neal D. Freedman
Summary: The PLCO Cancer Screening Trial is a prospective cohort study that developed the PLCO Atlas Project, a large resource for GWAS. Genotyping was performed on participants with available DNA, and GWAS were conducted using a custom pipeline. The PLCO Atlas GWAS Explorer website, with APIs and SDKs, allows for exploration, visualization, and open data access. It currently hosts association data for 90 traits and >78 million genomic markers, focusing on cancer-related phenotypes. The PLCO Atlas is a FAIR resource for cancer research and genetic epidemiology.
Article
Oncology
Arash Etemadi, Christian C. Abnet, Sanford M. Dawsey, Neal D. Freedman
Summary: Biomarkers can provide unique information about cancer risk factors by measuring the internal dose of carcinogens. Smoke-related biomarkers, including tobacco-specific biomarkers and those from exposure to tobacco and non-tobacco pollutants, are commonly studied in relation to cancer. Biomonitoring is superior to self-reported exposure assessment and will continue to be essential to cancer research.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Wayne R. Lawrence, Jasmine A. McDonald, Faustine Williams, Meredith S. Shiels, Neal D. Freedman, Ziqiang Lin, Jared W. Magnani
Summary: Chronic stress is hypothesized to be associated with breast cancer, but previous studies have shown mixed results. This study examined the association between self-reported stressful life events and incident breast cancer in postmenopausal women, taking into account estrogen receptor (ER) status and social support. The results showed that there was no relationship between stressful life events and ER-positive breast cancer, but there was an increased risk of ER-negative breast cancer in women with higher levels of stressful life events. This association was stronger in widowed women. Social support did not modify the relationship between stressful life events and ER-negative breast cancer.
CANCER PREVENTION RESEARCH
(2023)
Article
Oncology
Vicky C. C. Chang, Jongeun Rhee, Sonja I. I. Berndt, Steven C. C. Moore, Neal D. D. Freedman, Rena R. R. Jones, Debra T. T. Silverman, Gretchen L. L. Gierach, Jonathan N. N. Hofmann, Mark P. P. Purdue
Summary: In this nested case-control study, prediagnostic serum levels of PFOS and PFOA were found to be associated with breast cancer risk, particularly for hormone receptor-positive tumors, providing evidence of a possible positive association.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Anika T. Haque, Amy Berrington de Gonzalez, Yingxi Chen, Emily A. Haozous, Maki Inoue-Choi, Wayne R. Lawrence, Jennifer K. McGee-Avila, Anna M. Napoles, Eliseo J. Perez-Stable, Kekoa Taparra, Jacqueline B. Vo, Neal D. Freedman, Meredith S. Shiels
Summary: The study estimated cancer death rates among different racial and ethnic groups in the United States from 2018 to 2020. The results found significant disparities in cancer death rates, with the highest rates observed among Black individuals and Native Hawaiian and Pacific Islander (NHPI) individuals. Separating NHPI and Asian individuals revealed large differences in cancer mortality between the two groups that were previously combined in vital statistics data.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Xiaoshuang Feng, Wendy Yi-Ying Wu, Justina Ucheojor Onwuka, Zahra Haider, Karine Alcala, Karl Smith-Byrne, Hana Zahed, Florence Guida, Renwei Wang, Julie K. Bassett, Victoria Stevens, Ying Wang, Stephanie Weinstein, Neal D. Freedman, Chu Chen, Lesley Tinker, Therese Haugdahl Nost, Woon-Puay Koh, David Muller, Sandra M. Colorado-Yohar, Rosario Tumino, Rayjean J. Hung, Christopher Amos, Xihong Lin, Xuehong Zhang, Alan A. Arslan, Maria-Jose Sanchez, Elin Pettersen Sorgjerd, Gianluca Severi, Kristian Hveem, Paul Brennan, Arnulf Langhammer, Roger L. Milne, Jian-Min Yuan, Beatrice Melin, Mikael Johansson, Hilary A. Robbins, Mattias Johansson
Summary: This study aimed to develop a proteomics-based risk model for lung cancer and compare its performance with a smoking-based risk model and a commercially available autoantibody biomarker test. We conducted a case-control study in 6 prospective cohorts, involving 624 lung cancer participants and 624 smoking-matched cancer free participants. The protein-based risk model showed promise in predicting incident lung cancer and outperformed the standard risk prediction model and the commercialized EarlyCDT-Lung.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Biochemistry & Molecular Biology
Linda Kachuri, Thomas J. Hoffmann, Yu Jiang, Sonja I. Berndt, John P. Shelley, Kerry R. Schaffer, Mitchell J. Machiela, Neal D. Freedman, Wen-Yi Huang, Shengchao A. Li, Ryder Easterlin, Phyllis J. Goodman, Cathee Till, Ian Thompson, Hans Lilja, Stephen K. Van Den Eeden, Stephen J. Chanock, Christopher A. Haiman, David V. Conti, Robert J. Klein, Jonathan D. Mosley, Rebecca E. Graff, John S. Witte
Summary: Prostate-specific antigen (PSA) screening for prostate cancer remains controversial due to overdiagnosis and overtreatment. However, accounting for genetic determinants of PSA variation may improve screening accuracy.
Article
Oncology
Meredith S. Shiels, Stanley Lipkowitz, Nicole G. Campos, Mark Schiffman, John T. Schiller, Neal D. Freedman, Amy Berrington de Gonzalez
Summary: President Biden and First Lady Dr. Biden have reignited the Cancer Moonshot with the goal of reducing age-standardized cancer mortality rates by at least 50% in the United States over the next 25 years. From 2000 to 2019, overall cancer death rates declined, driven by significant decreases in lung, colorectal, and breast cancer mortality. However, progress for other cancer types was less promising, highlighting the need for new strategies. Achieving the Moonshot goal requires maintaining or accelerating progress in controlling lung, colorectal, and breast cancer deaths, and developing new approaches for prostate, liver, pancreatic, and other cancers.
Meeting Abstract
Oncology
Courtney D. Dill, Dontray Trump, Rebecca Landy, Li Cheung, Wen-Yi Huang, Sonja Berndt, Neal Freedman, Hormuzd Katki
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Oncology
Courtney D. Dill, Dontray Trump, Rebecca Landy, Li Cheung, Wen-Yi Huang, Sonja Berndt, Neal Freedman, Hormuzd Katki
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Oncology
Courtney D. Dill, Dontray Trump, Rebecca Landy, Li Cheung, Wen-Yi Huang, Sonja Berndt, Neal Freedman, Hormuzd Katki
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)