XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent

Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes

(2016) Aris Polyzos et al.   HUMAN MOLECULAR GENETICS

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

(2016) Tanja Krainz et al.   ACS Central Science

Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice

(2015) Eloise Larson et al.   NEUROBIOLOGY OF DISEASE

Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats

(2015) Sabzali Javadov et al.   Oncotarget

Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s Disease

(2015) Helen Budworth et al.   PLoS Genetics

Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats

(2014) Nelson Escobales et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in vivo

(2013) Eugenia Trushina et al.   HUMAN MOLECULAR GENETICS

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

(2013) Luigi A. Nasto et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Knockout punch: cardiolipin oxidation in trauma

(2012) Robin B Chan et al.   NATURE NEUROSCIENCE

Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

(2012) Jing Ji et al.   NATURE NEUROSCIENCE

Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease

(2012) Zhiyin Xun et al.   Cell Reports

Unusual Structures Are Present in DNA Fragments Containing Super-Long Huntingtin CAG Repeats

(2011) Daniel Duzdevich et al.   PLoS One

Responses to Environmental Enrichment Differ with Sex and Genotype in a Transgenic Mouse Model of Huntington's Disease

(2010) Nigel I. Wood et al.   PLoS One

Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions☆

(2009) Valerian E. Kagan et al.   ADVANCED DRUG DELIVERY REVIEWS

Beyond the brain: widespread pathology in Huntington's disease

(2009) Jorien MM van der Burg et al.   LANCET NEUROLOGY

The metabolic profile of early Huntington's disease- a combined human and transgenic mouse study

(2008) Anna O.G. Goodman et al.   EXPERIMENTAL NEUROLOGY

Sex-dependent Effect of BAG1 in Ameliorating Motor Deficits of Huntington Disease Transgenic Mice

(2008) Adam L. Orr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice

(2008) A Jennifer Morton et al.   NEUROBIOLOGY OF DISEASE

CAG repeat lengths ≥335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse

(2008) I. Dragatsis et al.   NEUROBIOLOGY OF DISEASE