Article
Plant Sciences
Zarko Kulic, Thomas Ritter, Birgit Roeck, Jens Elsaesser, Heike Schneider, Stefan Germer
Summary: The Ginkgo extract EGb 761, produced with leaves of Ginkgo biloba, is a clinically proven remedy for improving age-associated cognitive impairment and quality of life in patients with mild dementia. The study focused on the structural class of proanthocyanidins in EGb 761, showing that it contains delphinidin and cyanidin as main building blocks.
Article
Plant Sciences
Akida Alishir, Ki Hyun Kim
Summary: The study identified a new compound, ginkgopanoside, from Ginkgo biloba fruit with antioxidant activity, suggesting its potential for pharmaceutical and functional food applications.
Article
Plant Sciences
Marija Kovac Tomas, Iva Jurcevic, Dunja Samec
Summary: In this study, a HPLC-DAD method was developed to separate and determine five major biflavonoids in ginkgo. Tissue-specific profiling revealed that biflavonoids were not detected in plant parts not in direct contact with the environment. Leaves had the highest total biflavonoids content, with sciadopitysin being the predominant compound, while amentoflavone was the predominant biflavonoid in the bark.
Article
Biochemistry & Molecular Biology
Min Yu, Dan Aoki, Takuya Akita, Syunya Fujiyasu, Shunsuke Takada, Yasuyuki Matsushita, Masato Yoshida, Kazuhiko Fukushima
Summary: In this study, cryo-TOF-SIMS/SEM was used to investigate the distribution of lignans and lignan glucosides in Ginkgo biloba stems. The most abundant lignan glucoside, olivil DG, was found to be mainly distributed in the phloem, ray parenchyma cells, and pith of Ginkgo biloba. The comparative accumulation of olivil DG provided insights into its transport pathways and storage sites in Ginkgo biloba. These findings contribute to the understanding of the biological functions of lignans and lignan glucosides.
Article
Biochemistry & Molecular Biology
Agata Walkowiak, Kacper Wnuk, Michal Cyrankiewicz, Bogumila Kupcewicz
Summary: Ginkgo biloba leaf extract is often adulterated in herbal products. In this study, a method combining 2T2D COS and MPCA was developed to detect potential adulteration in G. biloba food supplements using UV-Vis spectral data. The approach successfully differentiated supplements adulterated with rutin or lacking Ginkgo leaf extract.
Article
Biochemistry & Molecular Biology
Shuang Su, Xue-Qiong Yang, Ya-Bin Yang, Zhong-Tao Ding
Summary: Five new terpenoids, including a polyketide-terpenoid hybrid paraphaone and four eremophilane sesquiterpenoids, were isolated from the endophytic fungus Paraphaeosphaeria sp. cultured with Ginkgo biloba extract. These compounds exhibited significant antifungal and antifeedant activities against various phytopathogens and entomopathogens. The culture of Paraphaeosphaeria sp. using Ginkgo biloba medium could be a potential source of agricultural antibiotics.
Article
Chemistry, Analytical
Yongyi Li, Zhirong Cui, Ying Li, Juanjuan Gao, Rong Tao, Jixin Li, Yi Li, Jun Luo
Summary: This study proposed a comprehensive MN strategy combining FBMN and dual ionization mode MS/MS to successfully distinguish 95 compounds from Ginkgo biloba leaf extract and Ginkgo biloba leaf, with 70 high-confidence molecules assigned as mainly consisting of flavonoid glycosides, ginkgo-lides, and lignan glycosides. The research provided a new and efficient strategy for component identification and visualization of herbal medicine.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Jing Zhang, Jintang Cheng, Liu Yan, Yuetong Yu, Chenyang Hao, Anyi Zhao, Sha Chen, An Liu
Summary: In this study, a global profile of characteristic ion and neutral loss recognition strategy was used to discover eight undescribed ginkgolides and eight known ginkgolides in Ginkgo biloba L. These compounds exhibited antiplatelet aggregation activities and enriched the known structural diversity of ginkgolides. The application of mass spectrometry in the global profiling of natural products present in Ginkgo biloba L. was extended, which could aid chemists in rapidly discovering unreported compounds from a complex matrix.
Review
Pharmacology & Pharmacy
Zarko Kulic, Martin D. Lehner, Gunnar P. H. Dietz
Summary: The phytochemical composition of extracts derived from the same plant can vary significantly, affecting their pharmacokinetic and pharmacodynamic properties, and ultimately their clinical efficacy and safety. Regulating active constituent levels and reducing undesired substances is vital for ensuring the quality and consistency of herbal extracts. The heterogeneity of extracts should be carefully considered when evaluating the efficacy and safety of plant-derived remedies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Magdalena Sereda, Jun Xia, Polly Scutt, Malcolm P. Hilton, Amr El Refaie, Derek J. Hoare
Summary: This systematic review evaluated the effects of Ginkgo biloba for tinnitus in adults and children. The findings suggest that Ginkgo biloba may have little to no effect on reducing tinnitus symptoms compared to placebo. The evidence for other secondary outcomes was uncertain. The effectiveness and safety of Ginkgo biloba with concurrent interventions also remain unclear. Future research should use rigorous methodology and validated outcome measures.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Chemistry, Analytical
Jianmei Wang, Jinmin Zhang, Ngoc Thao Duyen Nguyen, Yu-An Chen, Jer-Tsong Hsieh, Xiaowei Dong
Summary: This study developed a new HPLC method to measure IR780 concentration in pharmaceutical formulations and a new LC-MS/MS method to measure IR780 concentration in tissue samples, particularly in liver and lung. These quantitative methods provide reliable measurements of IR780 in both formulations and biological samples, facilitating research on IR780 as a theranostic agent for cancer therapy and imaging.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Food Science & Technology
Lenka Ceslova, Katerina Pravcova, Miroslava Juricova, Jan Fischer
Summary: The study optimized rapid reversed-phase high performance liquid chromatography coupled to tandem mass spectrometry for the determination of phenolic compounds in mead. The most frequently occurred phenolic compounds in extracts included benzoic acid, caffeic acid, and salicylic acid. Some samples had low levels of phenolic compounds, with one sample showing a very high concentration of vanillin.
Article
Chemistry, Analytical
Laurent Nyssen, Marianne Fillet, Etienne Cavalier, Anne-Catherine Servais
Summary: This study compares the differences between 1-84 PTH standards from different manufacturers and the international standard, and proposes a quick and inexpensive quantitative method. The methods were fully validated and evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Laurent Nyssen, Marianne Fillet, Etienne Cavalier, Anne-Catherine Servais
Summary: The study aimed to compare 1-84 parathyroid hormone (PTH) standards from different manufacturers to the WHO international standard, while investigating CE and LC methods as quick and inexpensive quantitation methods. The research also revealed that some 1-84 PTH standards have content twice as high as indicated on the label.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemical Research Methods
Adal Mena-Garcia, Ana Isabel Ruiz-Matute, Ana Cristina Soria, Maria Luz Sanz
Summary: The study developed a new multi-analytical strategy using GC-MS and HPLC-UV-MS to evaluate the quality/authenticity of artichoke-based food supplements for obesity control. Various compounds were detected in the supplements, with some potentially related to heat treatment or added ingredients. The application of this multi-analytical strategy was found to be advantageous for detecting fraudulent practices and assessing the quality of the products.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Anesthesiology
Zsofia Engi, Ria Benko, Gyongyver Soos, Delia Szok, Melinda Csenki, Emese Csullog, Attila Balog, Dezso Csupor, Reka Viola, Peter Doro, Maria Matuz
Summary: This study analyzed the utilization of opioids in ambulatory care in Hungary from 2006 to 2020. The study found that the overall utilization of opioids increased during this period, driven by an increase in both weak and strong opioids. Tramadol was the most commonly used opioid, and oral administration was the dominant route of administration. The study also revealed an increase in opioid use for musculoskeletal pain and a significant decline in opioid use for cancer pain.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Plant Sciences
Balazs Kovacs, Nikoletta Szemeredi, Norbert Kusz, Tivadar Kiss, Boglarka Csupor-Loffler, Yu-Chi Tsai, Balint Racz, Gabriella Spengler, Dezso Csupor
Summary: In this study, sesquiterpene lactones were isolated from the aerial part of Ambrosia artemisiifolia and their cytotoxic and antiproliferative effects were investigated. The results showed that these compounds exhibited significant activity against tumor cell lines and demonstrated selectivity towards certain cell lines.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Barbara Toth, Andras Javorhazy, Peter Nyirady, Boglarka Csupor-Loffler, Peter Birinyi, George Zhanel, Kurt Naber, Reinhard Langer, Nora Vorhendi, Noemi Gede, Szilard Vancsa, Peter Hegyi, Dezso Csupor
Summary: This study aims to assess the safety and non-inferiority of bearberry as an alternative therapy for acute uncomplicated cystitis, compared with standard antibiotic therapy. The study will evaluate the efficacy and side effects of bearberry and monitor the recurrence rate and medication usage.
Review
Biochemistry & Molecular Biology
Fanni Adel Meznerics, Kata Illes, Fanni Dembrovszky, Peter Fehervari, Lajos Vince Kemeny, Kata Dorottya Kovacs, Norbert Miklos Wikonkal, Dezso Csupor, Peter Hegyi, Andras Banvolgyi
Summary: PRP is a promising steroid-free topical treatment for patchy alopecia areata, with similar efficacy to triamcinolone acetonide.
Review
Medicine, Research & Experimental
Kata Illes, Fanni Adel Meznerics, Fanni Dembrovszky, Peter Fehervari, Andras Banvolgyi, Dezso Csupor, Peter Hegyi, Tamas Horvath
Summary: This study evaluated the effectiveness of mastoid obliteration compared to the canal wall up (CWU) technique in cholesteatoma surgery through a systematic review and meta-analysis. The results showed that mastoid obliteration significantly reduced the proportion of residual and recurrent cholesteatoma, although the quality of the data was low.
Review
Chemistry, Medicinal
Eszter Bako, Peter Fehervari, Andras Garami, Fanni Dembrovszky, Emese Eszter Gunther, Peter Hegyi, Dezso Csupor, Andrea Boszormenyi
Summary: This study conducted a systematic review and meta-analysis to explore the effectiveness of topical essential oils in musculoskeletal disorders. The results showed that EO therapy had a positive impact on reducing pain and stiffness in these disorders.
Review
Otorhinolaryngology
Kata Illes, Dorottya Gergo, Zsuzsanna Keresztely, Fanni Dembrovszky, Peter Fehervari, Andras Banvoelgyi, Dezso Csupor, Peter Hegyi, Tamas Horvath
Summary: Based on a systematic review and meta-analysis, our study aimed to provide information about the factors that influence the success of tympanic membrane reconstruction. The factors including age, size of the perforation, opposite ear condition, and the surgeon's experience were found to have a significant effect on the success of tympanic membrane reconstruction.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Review
Geriatrics & Gerontology
Zsuzsanna Rago, Barbara Toth, Agnes Szalenko-Tokes, Zsolt Bella, Fanni Dembrovszky, Nelli Farkas, Szabolcs Kiss, Peter Hegyi, Maria Matuz, Noemi Toth, Imre Hegedus, Domokos Mathe, Dezso Csupor
Summary: Based on a meta-analysis of available clinical trials, we evaluated the efficacy of ivermectin in terms of time to viral clearance. The results showed that ivermectin treatment significantly reduced the time to viral clearance in mild to moderate COVID-19 cases compared to control groups. However, more studies are needed to improve the evidence of ivermectin use in COVID-19.
Review
Chemistry, Medicinal
Arash Salehi, Mustafa Ghanadian, Behzad Zolfaghari, Amir Reza Jassbi, Maryam Fattahian, Parham Reisi, Dezso Csupor, Ikhlas A. Khan, Zulfiqar Ali
Summary: This study provides a narrative review of diterpenoid alkaloids (DAs), a family of extremely important natural products found predominantly in some species of Aconitum and Delphinium (Ranunculaceae). DAs have long been a focus of research attention due to their numerous intricate structures and diverse biological activities, especially in the central nervous system (CNS). Although the role of tertiary nitrogen in ring A and the polycyclic complex structure are of great importance in drug-receptor affinity, recent advances in developing new drugs from DAs were insignificant due to their neurotoxicity.
Article
Food Science & Technology
Andrea Toth-Meszaros, Gantsetseg Garmaa, Peter Hegyi, Andras Banvolgyi, Bank Fenyves, Peter Fehervari, Andrea Harnos, Dorottya Gergo, Uyen Nguyen Do To, Dezso Csupor
Summary: Adaptogenic herbs can reduce stress by decreasing cortisol levels. In mentally stressed healthy adults, treatment with Withania somnifera for 56 or 60 days resulted in significant decreases in cortisol levels and perceived stress levels.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Meeting Abstract
Pharmacology & Pharmacy
M. A. Bahar, I. Y. Kusuma, M. Matuz, T. Ferenci, R. Benko, D. Csupor
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)
Meeting Abstract
Pharmacology & Pharmacy
R. Benko, M. Matuz, N. Nagy, D. Peter-Hederi, R. Ruzsa, Z. Engi, G. Bodo, L. Papp, D. Csupor, Z. Peto
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)
Meeting Abstract
Pharmacology & Pharmacy
A. Erszegi, M. Matuz, R. Benko, Z. Engi, G. Bodo, P. Doro, R. Viola, D. Csupor
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)
Meeting Abstract
Pharmacology & Pharmacy
H. Hambalek, R. Benko, R. Ruzsa, I. Y. Kusuma, G. Bodo, E. Hajdu, A. Visnyovszki, E. Papfalvi, Z. Peto, D. Csupor, M. Matuz
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)
Meeting Abstract
Pharmacology & Pharmacy
I. Horvath, R. Benko, M. Matuz, S. Sebok, D. Csupor, B. Hanko
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)