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Medicine, Research & Experimental
Ying Gao, Jie Zhang, Jiexia Pan, Sanjun Ying, Bang Lou, Qingliang Yang, Weiyong Hong, Gensheng Yang
Summary: The aim of this study is to establish a FOF1-ATP synthase molecular motor biosensor for accurate identification of colon cancer miRNAs. The FOF1-ATP synthase molecular motor was extracted and connected to the colon cancer-specific miR-17 capture probe. Signal probes were designed for dual-signal characterization to increase detection accuracy. The FOF1-ATPase rotation rate decreases when the signaling and capture probes combine with the target miRNA, resulting in a decrease in ATP synthesis.
Review
Chemistry, Medicinal
Song Zhang, Zhujun Cheng, Yanan Wang, Tianyu Han
Summary: The progress of miRNA drugs in clinical trials is slow due to the characteristic of targeting multiple genes, leading to inevitable adverse effects.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Editorial Material
Biochemistry & Molecular Biology
James Chen, Damian C. Ekiert
Summary: This paragraph describes a drug for treating multidrug-resistant tuberculosis, which targets the key enzyme ATP synthase in cellular respiration. A recent study shows that this drug, along with another inhibitor, prevents the enzymatic function by inhibiting the necessary rotational motions.
Article
Biochemistry & Molecular Biology
Zhanchen Dong, Xuejun Yang, Tianming Qiu, Yu An, Genghua Zhang, Qiujuan Li, Liping Jiang, Guang Yang, Jun Cao, Xiance Sun, Xiaofang Liu, Dan Liu, Xiaofeng Yao
Summary: This study found that exosomes derived from CIT-treated hepatocytes induce mitochondrial calcium accumulation and activate HSC through miR-181a-2-3p-mediated inhibition of MICU1 expression, shedding new light on the mechanism of liver fibrosis and CIT hepatotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Plant Sciences
Yan Yan
Summary: This review assesses recent progress in the identification of new mobile sRNAs, discussing their functions in coordinating developmental, physiological, and defense-related processes in plants. The forms of mobile sRNAs and their trafficking mechanisms are also discussed. The authors highlight the importance of this field for future research.
Editorial Material
Endocrinology & Metabolism
Salvatore Nesci, Giovanni Romeo
Summary: A recent study by Ganetzky et al. has discovered a de novo heterozygous variant in the catalytic subunit of mitochondrial F1FO-ATPase, which is found to be the main cause of an autosomal dominant syndrome associated with defective ATP production. This article describes how the dysfunction of F1FO-ATPase in primary congenital hypothyroidism is caused by the 'rotor free-wheeling'.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
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Biochemical Research Methods
Kelkar Vipul Ganesh, Deepu Mathew, Rehna Augustine, K. B. Soni, Swapna Alex, M. R. Shylaja, Anita K. Cherian
Summary: This paper describes the development of YVMV resistant lines in okra using RNAi strategy, successfully introducing fiC1 ORF into the plants and conferring resistance to the Yellow vein mosaic virus.
JOURNAL OF VIROLOGICAL METHODS
(2022)
Article
Biochemistry & Molecular Biology
Sweta Khanal, Beatriz Schueng Zancanela, Jacob Oche Peter, Alex Sutton Flynt
Summary: This study provides a comprehensive analysis of small RNAs in annelids, revealing a large number of microRNAs and piRNAs. The study also identifies the expression patterns and pathway composition of miRNAs and piRNAs related to animal development and metamorphosis. Additionally, the study finds that the configuration of RNAi factors in annelids is similar to that of other annelids and mollusks, suggesting the presence of similar biology in a wider clade.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
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Agronomy
Farzad Bidari, Yaghoub Fathipour, Sassan Asgari, Mohammad Mehrabadi
Summary: This study characterized and analyzed the expression of miRNA core genes in B. tabaci and investigated the impact of their silencing on the insect's fitness. The results showed that silencing the miRNA core genes reduced miRNA levels and affected the fertility and survival of B. tabaci. The miRNA core genes could serve as attractive targets for developing an RNAi-based strategy against this insect pest.
PEST MANAGEMENT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Chen Zhu, Jia-Hui Liu, Jian-Hua Zhao, Ting Liu, Yun-Ya Chen, Chun-Han Wang, Zhong-Hui Zhang, Hui-Shan Guo, Cheng-Guo Duan
Summary: A study has found that the fungal pathogen Verticillium dahliae counters cross-kingdom antifungal RNA interference (RNAi) by secreting a protein called VdSSR1. This protein suppresses the movement of small RNAs (sRNAs) between the host plant and the fungus, increasing the virulence of the fungus in plants.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
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Fisheries
Thaneeya Nantapojd, Sakol Panyim, Chalermporn Ongvarrasopone
Summary: The study found that wsv-miR-9 plays an important role in early viral gene expression, leading to a delay in viral replication when its expression is inhibited. This highlights the potential for wsv-miR-9 as a target for controlling WSSV infection in shrimp.
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Plant Sciences
Qi Li, Michel Canton, Hao Wu, Xudong Zhang, Janice Zale, Zhonglin Mou
Summary: Three new artificial microRNA vectors were constructed and evaluated, demonstrating high efficiency in silencing the citrus PHYTOENE DESATURASE gene.
PLANT CELL REPORTS
(2021)
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Biochemical Research Methods
Qingren Meng, Yanan Chu, Changjun Shao, Jing Chen, Jian Wang, Zhancheng Gao, Jun Yu, Yu Kang
Summary: This study reveals that human-adapted coronavirus strains have deleted some miRNA-targeted sites in human lungs compared to their close zoonic relatives, which may be a major driver of the host-jumping process. The data of SARS-CoV-2 and MERS-CoV strains suggest that stress from host miRNA environments continues even after epidemics in humans.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biotechnology & Applied Microbiology
Saurabh Verma, Priyanka, Yusuf Akhter, Sangeeta Saxena
Summary: This study proposes a novel protocol for targeting dicot infecting Begomoviruses' DNA-B using a simplified generic approach. By identifying siRNA producing regions and searching for suitable recombination-free regions, several promising hotspot regions have been found for producing specific and effective siRNAs. These hotspot regions derived from the nuclear shuttle protein (NSP)-encoding region show potential for long-term resistance against leaf curl-causing begomoviruses.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2022)
Article
Microbiology
Madelaine M. Usey, Diego Huet
Summary: Coiled-coil-helix-coiled-coil-helix (CHCH) domains play important roles in the biogenesis and function of mitochondria. Recent investigations found CHCH domain-containing subunits in the Toxoplasma gondii ATP synthase, but their function was unclear. This study demonstrates the essential role of two T. gondii ATP synthase subunits containing CHCH domains in parasite survival and ATP synthase stability and function. Knockdown of these subunits disrupts multiple aspects of mitochondrial morphology and mutation of key residues in the CHCH domains causes protein mis-localization.
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Plant Sciences
Monica Saifi, Nazima Nasrullah, Malik Mobeen Ahmad, Athar Ali, Jawaid A. Khan, M. Z. Abdin
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2015)
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Virology
Zainul A. Khan, Jawaid A. Khan
ARCHIVES OF VIROLOGY
(2017)
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Genetics & Heredity
Sameena Khatoon, Abhinav Kumar, Neera B. Sarin, Jawaid A. Khan
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Biotechnology & Applied Microbiology
Mohd. Akmal, Mirza S. Baig, Jawaid A. Khan
JOURNAL OF BIOTECHNOLOGY
(2017)
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Biotechnology & Applied Microbiology
Pravej Alam, Zainul Abdeen Khan, Malik Zainul Abdin, Jawaid A. Khan, Parvaiz Ahmad, Shereen F. Elkholy, Mahmoud A. Sharaf-Eldin
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Biotechnology & Applied Microbiology
Pravej Alam, Zainul Abdeen Khan, Malik Zainul Abdin, Jawaid A. Khan, Parvaiz Ahmad, Shereen F. Elkholy, Mahmoud A. Sharaf-Eldin
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Genetics & Heredity
Shweta, Yusuf Akhter, Jawaid Ahmad Khan
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Virology
Jitendra Kumar, Sudhir P. Singh, Abhinav Kumar, Jawaid A. Khan, Rakesh Tuli
ARCHIVES OF VIROLOGY
(2013)
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Genetics & Heredity
A. Kumar, J. Kumar, J. A. Khan
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Biotechnology & Applied Microbiology
Razia Qadir, Zainul A. Khan, Dilip Monga, Jawaid A. Khan
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Biotechnology & Applied Microbiology
Sadia Akhtar, Mohd Akmal, Jawaid A. Khan
INDIAN JOURNAL OF BIOTECHNOLOGY
(2017)
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Biotechnology & Applied Microbiology
G. Wamiq, S. Akhtar, Z. A. Khan, P. Alam, J. A. Khan
INDIAN JOURNAL OF BIOTECHNOLOGY
(2016)
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Biotechnology & Applied Microbiology
M. Sarwar Baig, Jawaid A. Khan
INDIAN JOURNAL OF BIOTECHNOLOGY
(2013)
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Biotechnology & Applied Microbiology
Javed Ahmad, Braj Raj Singh, Abdulaziz A. Al-Khedhairy, Saud Alarifi, Jawaid A. Khan, Javed Musarrat
AFRICAN JOURNAL OF BIOTECHNOLOGY
(2011)