期刊
PLANT SCIENCE
卷 273, 期 -, 页码 84-91出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.plantsci.2018.03.012
关键词
Synthetic biology; Plant metabolism; Central carbon metabolism; Metabolic engineering; Bio-based economy
资金
- National Center for Complementary and Integrative Health (NCCIH) at the National Institutes of Health [1K99AT009573]
- U. S. Department of Energy, Office of Science, Office of Biological and Environmental Research [DE-AC02-05CH11231]
- Joint BioEnergy Institute
Humans have domesticated many plant species as indispensable sources of food, materials, and medicines. The dawning era of synthetic biology represents a means to further refine, redesign, and engineer crops to meet various societal and industrial needs. Current and future endeavors will utilize plants as the foundation of a bio-based economy through the photosynthetic production of carbohydrate feedstocks for the microbial fermentation of biofuels and bioproducts, with the end goal of decreasing our dependence on petrochemicals. As our technological capabilities improve, metabolic engineering efforts may expand the utility of plants beyond sugar feedstocks through the direct production of target compounds, including pharmaceuticals, renewable fuels, and commodity chemicals. However, relatively little work has been done to fully realize the potential in redirecting central carbon metabolism in plants for the engineering of novel bioproducts. Although our ability to rationally engineer and manipulate plant metabolism is in its infancy, I highlight some of the opportunities and challenges in applying synthetic biology towards engineering plant primary metabolism.
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