期刊
PLANT SCIENCE
卷 274, 期 -, 页码 146-152出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.plantsci.2018.05.009
关键词
Autophagy; Metabolomics; Nutrient recycling; Omics; Proteomics; Transcriptomics
资金
- National Natural Science Foundation of China [31770356]
- South China Agricultural University [4600-K15409]
- National Institutes of Health, National Institute of General Medical Science [R01-GM124452-01A1]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM124452, R01GM127892] Funding Source: NIH RePORTER
Autophagy is a highly conserved pathway in eukaryotes that promotes nutrient recycling and cellular home-ostasis through the degradation of excess or damaged cytoplasmic constituents. In plants, autophagy is increasingly recognized as a key contributor to development, reproduction, metabolism, leaf senescence, endosperm and grain development, pathogen defense, and tolerance to abiotic and biotic stresses. Characterizing the functional transcriptomic, proteomic, and metabolomic networks relating to autophagy in plants subjected to various extra- and intra-cellular stimuli may help to identify components associated with the pathway. As such, the integration of multi-omics approaches (i.e., transcriptomics, proteomics and metabolomics), along with cellular, genetic and functional analyses, could provide a global perspective regarding the effects of autophagy on plant metabolism, development and stress responses. In this mini-review, recent research progress in plant autophagy is discussed, highlighting the importance of high-throughput omics approaches for defining the underpinning molecular mechanisms of autophagy and understanding its associated regulatory network.
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