FBXW7 regulates a mitochondrial transcription program by modulating MITF

FBXW7 inactivation in a Braf V600E -driven mouse model leads to melanoma development

(2017) Iraz T. Aydin et al.   Pigment Cell & Melanoma Research

Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond

(2015) Nikos Kourtis et al.   CURRENT OPINION IN CELL BIOLOGY

The roles of microphthalmia-associated transcription factor and pigmentation in melanoma

(2014) Jennifer J. Hsiao et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities

(2014) Ryan J. Davis et al.   CANCER CELL

FBXW7 Mutations in Melanoma and a New Therapeutic Paradigm

(2014) Iraz T. Aydin et al.   JNCI-Journal of the National Cancer Institute

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

Elucidating Distinct Roles for NF1 in Melanomagenesis

(2012) Ophélia Maertens et al.   Cancer Discovery

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

SCFCdc4 acts antagonistically to the PGC-1  transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

(2008) B. L. Olson et al.   GENES & DEVELOPMENT

FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

(2008) Jian-Hua Mao et al.   SCIENCE