Article
Immunology
Mingjun Li, Xiangwen Shi, Yipeng Wu, Baochuang Qi, Chaoqun Zhang, Bin Wang, Bihuan Zhang, Yongqing Xu
Summary: This study explores the mechanisms of BMSCs injury and osteogenic differentiation inhibition in osteomyelitis, and identifies a potential therapeutic target. The results show that knocking down the Pmepa1 gene can alleviate infection-induced cell injury and promote osteoblast differentiation. The findings are supported by results from a rat model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Materials Science, Biomaterials
Anil Sera Cakmak, Sumeyra Fuerkaiti, Dilara Karaguzel, Cagatay Karaaslan, Menemse Gumusderelioglu
Summary: This study demonstrates that the CRISPR/Cas9 mechanism can be used to knockout the Noggin gene, thereby increasing the activity of BMP-2 signaling and promoting osteogenic differentiation. The findings suggest that CRISPR/Cas9 has great potential as a tool for obtaining new cell sources for tissue engineering studies.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Cell Biology
Elia Bosch-Rue, Leire Diez-Tercero, Barbara Giordano-Kelhoffer, Luis M. Delgado, Begona M. Bosch, Mireia Hoyos-Nogues, Miguel Angel Mateos-Timoneda, Phong A. Tran, Francisco Javier Gil, Roman A. Perez
Summary: Bone is the most studied tissue in tissue regeneration field, with tissue engineering seeking to mimic successful regeneration pathways. The use of inorganic ions has therapeutic effects and lower biological risks, with biomaterials playing a key role in controlling their release.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Mingjun Li, Christoph Schlaich, Jianguang Zhang, Ievgen S. Donskyi, Karin Schwibbert, Frank Schreiber, Yi Xia, Jorg Radnik, Tanja Schwerdtle, Rainer Haag
Summary: This study successfully introduced antibacterial and osteogenic properties simultaneously in biomaterials by incorporating copper nanoparticles into a PCL membrane, leading to effective bactericidal activity against S. aureus, E. coli, and multidrug-resistant E. coli, as well as upregulation of osteoblast-related gene expressions and protein activity.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takehiro Yamamoto, Zhicheng Diao, Masaru Murakami, Fumie Shimokawa, Tohru Matsui, Masayuki Funaba
Summary: This study demonstrates the induction of UCP1 expression in C2C12 cells through treatment with BMP and certain hormones, providing basic information for the practical differentiation of myogenic cells to brown adipocytes.
Article
Biochemistry & Molecular Biology
Takehiro Yamamoto, Zhicheng Diao, Masaru Murakami, Fumie Shimokawa, Tohru Matsui, Masayuki Funaba
Summary: Treatment with rosiglitazone, GW501516, and BMP7 efficiently increased UCP1 expression in C2C12 cells, suggesting that inducing pluripotent stem cells to differentiate into brown adipocytes may become a therapeutic approach for obesity and metabolic diseases.
Article
Biochemistry & Molecular Biology
Dilara Yeniterzi, Zeynep Demirsoy, Aytul Saylam, Salih Ozcubukcu, Gulcihan Gulseren
Summary: Enzyme mimicry is a challenging field in biomaterials research, and the development of self-assembling multifunctional nanostructures has brought us closer to achieving enzymes with similar catalytic activity and biological functions.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Multidisciplinary Sciences
Sirikool Thamnium, Chavee Laomeephol, Prasit Pavasant, Thanaphum Osathanon, Yasuhiko Tabata, Chao Wang, Jittima A. Luckanagul
Summary: This study evaluated the osteogenic induction activity of AA derivatives in human periodontal ligament stem cells. The results showed that four compounds, 501, 502, 503, and 506, had different water solubility and toxicity. Compound 506 demonstrated a high potency in inducing osteogenic differentiation by upregulating BMP2 via the Erk signalling pathway. Therefore, the 506 molecule shows promise in bone tissue regeneration.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Yueqi Zhao, Lin Meng, Kai Zhang, Yuanqing Sun, Yue Zhao, Zhe Yang, Yangliu Lin, Xinrui Liu, Hongchen Sun, Bai Yang, Quan Lin
Summary: This study successfully synthesized fluorescent gold nanodots (Au NDs) as osteogenic induction reagents, and utilized oligopeptides with negative charges to enhance the differentiation of human bone morrow mesenchyme stem cells (hBMSCs) into skeletal tissues.
CHINESE CHEMICAL LETTERS
(2021)
Article
Endocrinology & Metabolism
Francesca Liuzzi, Marilena Taggi, Serena De Carlini, Antonio La Marca
Summary: This study provides evidence for the expression and functionality of AMHRII in HOb cells, suggesting that AMH may have stimulatory effects on osteoblasts and could be a potential candidate for treating osteoporosis.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Cell Biology
Huakun Huang, Qiuping Lu, Caihong Ye, Mengqi Wei, Chunmei Yang, Lulu Zhang, Yanran Huang, Xiaoji Luo, Jinyong Luo
Summary: TAZ promotes osteogenic differentiation induced by BMP9 through multiple signal pathways.
CELL DEATH DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Jin Wook Hwang, Youn Ho Han
Summary: In this study, a promising peptide, BCP1, was identified as a potential alternative therapy for bone formation. The results showed that BCP1 promotes osteogenicity in C2C12 cells, indicating its potential importance in bone formation-related treatments.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2023)
Article
Plant Sciences
Umashankar Chandrasekaran, Siyeon Byeon, Kunhyo Kim, Seo Hyun Kim, Chan Oh Park, Ah Reum Han, Young-Sang Lee, Hyun Seok Kim
Summary: Climate change-related drought stress affects the physiology and biochemistry of eastern white pine, leading to changes in chlorophyll content, proline accumulation, antioxidant activity, root/shoot ratio, and synthesis of volatile organic compounds.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Carla Ferreira-Baptista, Andre Queiros, Rita Ferreira, Maria Helena Fernandes, Bruno Colaco, Pedro Sousa Gomes
Summary: Mesenchymal stromal cells (MSCs) from adipose tissue, especially from the falciform ligament (FL-ADSCs), show potential as a source for bone tissue regeneration. This study aimed to characterize the osteogenic functionality of FL-ADSCs compared to control ADSCs from a visceral region. The FL-derived populations expressed higher levels of osteogenic genes and markers, particularly with dexamethasone induction, while control ADSCs were more responsive to retinoic acid. FL-ADSCs were identified as a potential source for bone regenerative applications, and the selection of the most suitable osteogenic induction program is crucial.
BIOENGINEERING-BASEL
(2022)
Review
Cell Biology
Shogo Ehata, Kohei Miyazono
Summary: Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) family, are multifunctional cytokines that play a dual role in cancer, acting as both tumor promoters and suppressors. They regulate cancer cell proliferation, malignant phenotypes, and angiogenesis in the tumor microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biology
Palaniselvam Kuppusamy, Dahye Kim, Ilavenil Soundharrajan, Inho Hwang, Ki Choon Choi
Summary: Co-culture systems provide a novel platform for studying interactions between different cell types, playing a key role in understanding cell-cell communication and drug response analysis. These systems can influence therapeutic drug responses in a dose-dependent manner, reflecting clinical situations, and may mimic realistic environments with phenotypic and functional characteristics resembling in vivo conditions. The co-culture methods are shown to have wide applications in cell biology studies, particularly in investigating interactions between adipose and muscle tissue under various environments.
Article
Biochemistry & Molecular Biology
Palaniselvam Kuppusamy, Soundharrajan Ilavenil, In Ho Hwang, Dahye Kim, Ki Choon Choi
Summary: The study found that ferulic acid (FA) can significantly inhibit adipogenesis and lipid accumulation, enhance lipolysis by regulating key adipocyte factors and enzymes, and decrease adipocyte differentiation markers, showing potential as a potent molecule to prevent obesity and associated metabolic changes in the future.
Article
Multidisciplinary Sciences
R. Murugesan, K. Vasuki, B. Kaleeswaran, P. Santhanam, S. Ravikumar, Mona S. Alwahibi, Dina A. Soliman, Bandar Mohsen Ahmed Almunqedhi, Jawaher Alkahtani
Summary: The study demonstrates that Solanum torvum leaf extract shows good repellent and contact toxicity effects against Callosobruchus maculatus adult, suggesting its potential for integrated pest management as an alternative to chemical insecticides.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Environmental Sciences
Mysoon M. Al-Ansari, Hicham Benabdelkamel, Reem H. AlMalki, Anas M. Abdel Rahman, Eman Alnahmi, Afshan Masood, Soundharrajan Ilavenil, Ki Choon Choi
Summary: The study evaluated the potential of a biocatalyst strain for heavy metal removal and identified a bacterial strain suitable for such removal; it found that SBR could efficiently remove heavy metals from wastewater within 10 hours and also exhibited good removal efficacy for other pollutants in water.
ENVIRONMENTAL RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Ilavenil Soundharrajan, Hyung Soo Park, Sathya Rengasamy, Ravikumar Sivanesan, Ki Choon Choi
Summary: Ensiling is a key process for preserving high-nutrient fodder with microbiological quality. Adding potent starter cultures like lactic acid bacteria (LABs) can effectively control unwanted microbial growth and promote animal growth. Scientists are increasingly focusing on developing nutrient-rich animal feed from forages using LABs.
APPLIED SCIENCES-BASEL
(2021)
Article
Public, Environmental & Occupational Health
Khaloud M. Alarjani, Abeer M. Almutairi, Fatmah S. AlQahtany, Ilavenil Soundharrajan
Summary: Neonatal infection is a serious issue that can lead to high mortality rates. The study found that Staphylococcus aureus and Klebsiella pneumoniae are the most common pathogens, with a high prevalence of multidrug-resistant strains. Therefore, more attention is needed in diagnosing and preventing neonatal sepsis.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Agricultural Engineering
Jeong Sung Jung, Balasubramani Ravindran, Ilavenil Soundharrajan, Mukesh Kumar Awasthi, Ki Choon Choi
Summary: The addition of LAB can improve fermentation characteristics, reduce pH values, increase lactic acid production, and decrease acetic acid and butyric acid concentrations in triticale silages. By enhancing the efficiency of fermentation and improving quality, LAB treatment shows the potential to increase the dominance of desirable Lactobacillus and inhibit the growth of undesirable microbes in silages.
BIORESOURCE TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Balamuralikrishnan Balasubramanian, Ilavenil Soundharrajan, Naif Abdullah Al-Dhabi, Ponnuswamy Vijayaraghavan, Kaleeswaran Balasubramanian, Mariadhas Valan Arasu, Ki Choon Choi
Summary: This study identified a potent lactic acid bacteria strain, L. salivarius AS22, from sheep dung, which showed high fermentation capability and antimicrobial activity, improving the quality of corn and foxtail millet silage. Results demonstrated that silage inoculated with L. salivarius AS22 significantly enhanced lactic acid production, decreased pH value, and reduced fungal colony counts.
APPLIED SCIENCES-BASEL
(2021)
Article
Public, Environmental & Occupational Health
Ganesan Govindarajan, Priya Mullick, Babu Arulmani Samuel Raj, Pachaiyappan Saravana Kumar, Mysoon M. Al-Ansari, Soundharrajan Ilavenil, Robinson David Jebakumar Solomon
Summary: This study isolated a diverse group of actinomycetes strains from unexplored regions of mangrove sediments, some of which exhibited strong antibacterial activity, particularly against MRSA and Gram-negative bacteria. Through 16S rRNA gene sequence analysis, it was confirmed that these strains shared high similarity with Streptomyces species.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
K. Ancy, M. R. Bindhu, Jeslin Sunitha Bai, Mansour K. Gatasheh, Ashraf Atef Hatamleh, S. Ilavenil
Summary: This study evaluated the successful synthesis of Al-F co-doped TiO2 nanoparticles for degrading organic synthetic dyes and textile dyeing waste water. The influence of co-dopants was examined in their optical, structural, compositional, morphological, and vibrational properties, showing improvement in the photocatalytic performance of TiO2.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kyung Dong Lee, Soundharrajan Ilavenil, Muthusamy Karnan, Chul-Ju Yang, Dahye Kim, Ki Choon Choi
Summary: This study investigates the role of cell-free metabolites from Bacillus ginsengihumi-RO6 in adipogenesis and lipogenesis, suggesting a potential novel probiotic for treating obesity and metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ilavenil Soundharrajan, Muthusamy Karnan, Jeong-Sung Jung, Kyung-Dong Lee, Jeong-Chae Lee, Thiyagarajan Ramesh, Dahye Kim, Ki-Choon Choi
Summary: This study investigated the effects of Lactiplantibacillus plantarum-KCC48 on fatty liver disease induced by a high-fat diet. Transcriptome analysis was used to evaluate the changes in hepatic mRNA transcripts in mice fed a high-fat diet and mice fed a high-fat diet with L. plantarum. The results showed that L. plantarum-KCC48 treatment significantly regulated the expression of genes involved in fatty liver disease caused by a high-fat diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jeong Sung Jung, Ilavenil Soundharrajan, Dahye Kim, Myunggi Baik, Seungmin Ha, Ki Choon Choi
Summary: The diversity and function of bacteria in the cattle gastrointestinal tracts can affect animal welfare. This study used next-generation sequencing to investigate the microbial diversity in the feces of Hanwoo steers reared under different grazing and housing systems. The results showed that grazing had a significant impact on the fecal microbiota and serum metabolic markers of the steers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Ilavenil Soundharrajan, Jeong Sung Jung, Karnan Muthusamy, Bae Hun Lee, Hyung Soo Park, Ravikumar Sivanesan, Ki Choon Choi
Summary: In this study, the anaerobic fermentation in triticale silage was improved by adding lactic acid bacteria (LAB). The LAB treatment resulted in a decrease in pH, an increase in lactic acid content, and a decrease in butyric acid content in the silage. Furthermore, the LAB treatment suppressed the growth of yeast and mold, enhancing the nutritional quality of the silage.
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.