Article
Medicine, General & Internal
Nicolle Rakanidis Machado, Beatriz Oliveira Fagundes, Lorena Abreu Fernandes, Augusto Cesar Penalva de Oliveira, Youko Nukui, Jorge Casseb, Fernando Roberto Machado Cunha, Luiz Henrique da Silva Nali, Sabri Saeed Sanabani, Jefferson Russo Victor
Summary: This study found that IgG obtained from HAM/TSP and ATLL patients can differentially modulate the cytokine production by human T and B cells, and elicit distinct effects on target populations.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Soumitra Marathe, Bhavuk Dhamija, Sushant Kumar, Nikita Jain, Sarbari Ghosh, Jai Prakash Dharikar, Sumana Srinivasan, Sreya Das, Abhijeet Sawant, Saloni Desai, Farhat Khan, Abigail Syiemlieh, Manohar Munde, Chitra Nayak, Mayuri Gandhi, Ashutosh Kumar, Sanjeeva Srivastava, K. V. Venkatesh, Steven R. Barthel, Rahul Purwar
Summary: IL-9 plays a critical role in metabolic reprogramming and survival of human primary keratinocytes by disrupting the electron transport chain, reducing tricarboxylic acid cycle intermediates, promoting glucose consumption, and inhibiting apoptosis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Michael Brandon Ware, Maggie Phillips, Christopher McQuinn, Mohammad Y. Zaidi, Hannah M. Knochelmann, Emily Greene, Brian Robinson, Cameron J. Herting, Thomas A. Mace, Zhengjia Chen, Chao Zhang, Matthew R. Farren, Amanda N. Ruggieri, Jacob S. Bowers, Reena Shakya, Alton B. Farris, Gregory Young, William E. Carson III, Bassel El-Rayes, Chrystal M. Paulos, Gregory B. Lesinski
Summary: This study demonstrates that anti-IL-6 and anti-CTLA-4 antibodies can enhance antitumor immune responses to pancreatic cancer. Dual blockade of IL-6 and CTLA-4 inhibits tumor growth by inducing T cell infiltrations and secretion of IFN-gamma by CD4+ T cells. The efficacy of this combination therapy is dependent on the CXCR3 axis and the presence of both CD4+ and CD8+ T cells.
Article
Chemistry, Multidisciplinary
Sarah Thomas, Juliane E. E. Fiebig, Eva-Maria Kuhn, Dominik S. S. Mayer, Sebastian Filbeck, Werner Schmitz, Markus Krischke, Roswitha Gropp, Thomas D. D. Mueller
Summary: Interleukin-4 (IL-4) and Interleukin-13 (IL-13) play key roles in atopic diseases by coordinating T-helper cell differentiation and inducing immunoglobulin class switch. IL-4 antagonists, including Pitrakinra, have been evaluated as potential therapeutic alternatives to neutralizing antibodies for treating asthma. This study explores the use of glycoengineering and chemical attachment strategies to improve the effectiveness and proteolytic stability of IL-4 antagonists.
Article
Biology
Bilal Ahmad Wani, Faheem Shehjar, Sonaullah Shah, Ajaz Koul, Adfar Yusuf, Masqooba Murtaza, Rajni Singh, Fayez Althobaiti, Adil Aldhahrani, Dil Afroze
Summary: Studies show a significant association of IL-10 and IFN-gamma gene polymorphisms with extrapulmonary tuberculosis (ETB) in ethnic Kashmiri population.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Shanmuga Sundaram Mahalingam, Sangeetha Jayaraman, Adhvika Arunkumar, Holly M. Dudley, Donald D. Anthony, Carey L. Shive, Jeffrey M. Jacobson, Pushpa Pandiyan
Summary: Individuals aged >61 show intrinsic changes in T cell responses during SARS-CoV-2 infection, including reduced cytokine production capacity and increased PD-1(+) cells. These findings may provide insights into dysregulated immune responses in COVID-19 in the elderly.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Catarina M. Ferreira, Ana Margarida Barbosa, Palmira Barreira-Silva, Ricardo Silvestre, Cristina Cunha, Agostinho Carvalho, Fernando Rodrigues, Margarida Correia-Neves, Antonio G. Castro, Egidio Torrado
Summary: IL-10 acts on CD4(+) T cells during Mycobacterium tuberculosis infection, impairing their ability to migrate into the lung parenchyma and interact with infected phagocytic cells, thereby impeding the control of infection.
Article
Immunology
Madhuparna Nandi, Mitterrand Muamba Moyo, Sakina Orkhis, Jeanne Masunga Faida Mobulakani, Marc-Andre Limoges, Fjolla Rexhepi, Marian Mayhue, Anny Armas Cayarga, Gisela Cofino Marrero, Subburaj Ilangumaran, Alfredo Menendez, Sheela Ramanathan
Summary: Interleukin-15 (IL-15) regulates immune cell activity by forming a trimeric complex with IL-15Rα, but can also signal through the IL-15Rβγ(c) dimer. IL-15 deficiency results in the inability to control bacterial infections, while mice lacking IL-15Rα are able to effectively clear pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Wei-Jia Luo, Sung-Liang Yu, Chia-Ching Chang, Min-Hui Chien, Ya-Ling Chang, Keng-Mao Liao, Pei-Chun Lin, Kuei-Pin Chung, Ya-Hui Chuang, Jeremy J. W. Chen, Pan-Chyr Yang, Kang-Yi Su
Summary: HLJ1 knockout mice show reduced organ injury and mortality in lipopolysaccharide-induced endotoxic shock. HLJ1 deletion affects IFN-gamma-related gene signatures in distinct immune cell clusters. HLJ1 deficiency leads to reduced IL-12 levels, dampened IFN-gamma production in natural killer cells, and improved survival rate. HLJ1 converts misfolded IL-12p35 homodimers to monomers, maintaining bioactive IL-12p70 heterodimerization and secretion.
Article
Medicine, General & Internal
Taosheng Ye, Jiaohong Zhang, Xuan Zeng, Yuxiang Xu, Min Li
Summary: This study found that levels of IFN-gamma, IL-10, IL-12, and CCL1 in the serum of patients with pulmonary tuberculosis are significantly increased, indicating immune impairment. After treatment, these levels decreased and were found to be correlated with other inflammatory markers.
ACTA MEDICA MEDITERRANEA
(2021)
Article
Biochemistry & Molecular Biology
Mengdie Li, Fengrun Sun, Jinfeng Qian, Lanting Chen, Dajin Li, Songcun Wang, Meirong Du
Summary: Establishing maternal-fetal tolerance and successful placentation are crucial for a successful pregnancy, as disruption of immune balance and inadequate placental perfusion can lead to pregnancy-related complications. Extravillous trophoblasts play a key role in regulating decidual immune cells for fetal tolerance. Blocking Tim-3 and CTLA-4 pathways can lead to abnormal interaction between decidual immune cells and extravillous trophoblasts, resulting in poor placental development and increased fetal loss. IL-4 and IL-10 treatment may rescue the adverse effects of targeting Tim-3 and CTLA-4 on pregnancy outcomes, suggesting them as potential therapeutic strategies to prevent pregnancy loss induced by checkpoint inhibition.
Article
Cell Biology
Ryota Hashimoto, Hiroshi Koide, Youichi Katoh
Summary: Lipopolysaccharide (LPS) is an endotoxin that induces acute inflammatory response by activating macrophages to produce nitric oxide (NO) through the RAS-RAF-MEK-ERK signaling cascade. This study showed that the combination of LPS and MEK inhibitors enhanced NO production and mortality in mice with LPS-induced inflammation. The MEK inhibitor enhanced IL-12 expression and synergistically induced NO production with TNF-alpha, contributing to the increased mortality rate.
CELL DEATH DISCOVERY
(2023)
Article
Immunology
Junichi Ishikawa, Akira Suto, Kazuya Abe, Yuki Hayashi, Kensuke Suga, Shigeru Tanaka, Takahiro Kageyama, Arifumi Iwata, Kazumasa Suzuki, Kotaro Suzuki, Hiroshi Nakajima
Summary: Murine IL-17-producing γδT (γδT17) cells consist of natural γδT17 (nγδT17) cells and inducible γδT17 cells. IL-21 is dispensable for the fetal thymic development of nγδT17 cells, but required for the peripheral maintenance of Vδ4(+)nγδT17 cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zixi Wang, Di Guan, Jianxin Huo, Subhra K. Biswas, Yuhan Huang, Yuansheng Yang, Shengli Xu, Kong-Peng Lam
Summary: The study demonstrates that IL-10 upregulates both glycolysis and oxidative phosphorylation in human NK cells, crucial for their enhanced effector functions. Mechanistically, it is revealed that IL-10 activates the mammalian target of rapamycin complex 1 (mTORC1) to regulate metabolic reprogramming in human NK cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Selma Tuzlak, Anne S. Dejean, Matteo Iannacone, Francisco J. Quintana, Ari Waisman, Florent Ginhoux, Thomas Korn, Burkhard Becher
Summary: Three decades ago, the description of helper T cell polarization led to a dramatic growth in the T cell universe, with new subsets emerging. Categorizing T helper cells based on the help they provide offers a better understanding of their complexity and diversity.
Article
Biochemistry & Molecular Biology
Mostafa Dastani, Hamid Reza Rahimi, Vahid Reza Askari, Mahmoud Reza Jaafari, Lida Jarahi, Asal Yadollahi, Vafa Baradaran Rahimi
Summary: Nano-curcumin has a significant impact on cardiovascular risk factors in type 2 diabetic patients, reducing inflammation marker hs-CRP and lipoprotein levels, and potentially preventing atherosclerosis progression and cardiovascular events.
Article
Biochemistry & Molecular Biology
Farzad Kermani, Simin Nazarnezhad, Zahra Mollaei, Sahar Mollazadeh, Alireza Ebrahimzadeh-Bideskan, Vahid Reza Askari, Reza Kazemi Oskuee, Ali Moradi, Seyede Atefe Hosseini, Zoleikha Azari, Francesco Baino, Saeid Kargozar
Summary: Zn- and Cu-doped 13-93B3 borate mesoporous bioactive glasses (MBGs) were synthesized using nitrate precursors in the presence of Pluronic P123. The mineralization process of hydroxyapatite (HAp) on the glass surface was investigated by studying the changes in dynamic surface tension (SFT) of simulated body fluid (SBF). The doped MBGs showed changes in various properties and the SFT of SBF was found to be an important factor for predicting and confirming the HAp mineralization process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Vahid Reza Askari, Zohreh Najafi, Vafa Baradaran Rahimi, Mohammad Hossein Boskabady
Summary: This study aimed to investigate and compare the anti-inflammatory properties of visnagin and its methoxy derivative khellin on human lymphocytes. The results showed that khellin and visnagin significantly reduced cell proliferation, malondialdehyde (MDA), and nitric oxide (NO) levels, and increased glutathione (GSH) and interleukin (IL)-10 levels. Khellin had a more prominent anti-inflammatory effect compared to visnagin.
PHARMACOLOGICAL REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Legha Ansari, Habibeh Mashayekhi-Sardoo, Vafa Baradaran Rahimi, Roghayeh Yahyazadeh, Majid Ghayour-Mobarhan, Vahid Reza Askari
Summary: Despite its low solubility and bioavailability, CUR-incorporated nanoformulation enhances various wound healing processes. Different nanoformulations, including nanofibers, nanoparticles, nanoemulsion, and nanoliposome, have been extensively studied and described. These formulations ensure the sustained release of CUR and improve its presence during the entire healing period.
Article
Biochemistry & Molecular Biology
Vafa Baradaran Rahimi, Saeideh Saadat, Pouria Rahmanian Devin, Ali Jebalbarezy, Maryam Moqaddam, Mohammad Hossein Boskabady, Vahid Reza Askari
Summary: Crocetin, a natural compound derived from Crocus sativus, has immunoregulatory and anti-inflammatory properties, which allow it to modulate the immune response in human lymphocytes. It can decrease pro-inflammatory cytokines and increase anti-inflammatory cytokines, promoting a shift towards a Th1 and Treg dominant response.
Article
Infectious Diseases
Reza Javidi Dasht Bayaz, Vahid Reza Askari, Mohammad Tayyebi, Mostafa Ahmadi, Alireza Heidari-Bakavoli, Vafa Baradaran Rahimi
Summary: This study evaluated 120 hospitalized patients with severe COVID-19 and found that cardiac injury is associated with increased mortality. It suggests that early diagnosis of cardiac injury and prevention of high mortality can be achieved through the detection of troponin I (TPI).
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Vafa Baradaran Rahimi, Pouria Rahmanian Devin, Vahid Reza Askari
Summary: This study aimed to investigate the effects of B. serrata pretreatment on LPS-induced cardiac damage in H9c2 cells. The results demonstrated that B. serrata might be a potential therapeutic agent against LPS and endotoxemia-induced cardiac injury, through its anti-inflammatory and antioxidant properties.
Article
Immunology
Hassan Rakhshandeh, Vafa Baradaran Rahimi, Bahman Dehghan-Naieri, Pouria Rahmanian-Devin, Ali Jebalbarezy, Maede Hasanpour, Mehrdad Iranshahi, Vahid Reza Askari
Summary: This study aimed to investigate the impacts of Glycyrrhiza glabra on the development of post-operative abdominal adhesion in a rat model. The results demonstrated that G. glabra could concentration-dependently mitigate adhesion formation through its anti-inflammatory, anti-fibrosis, and anti-oxidant properties. However, further clinical investigations are required to confirm G. glabra as a promising candidate against post-surgical adhesive complications.
INFLAMMOPHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Leila Bigdelu, Mahdi Hasanzadeh Daloee, Maryam Emadzadeh, Leila Parsa, Mahnaz Najafi, Vafa Baradaran Rahimi
Summary: Doppler echocardiography can be used to evaluate the characteristics of pulmonary embolism. Observing the early systolic notching (ESN) and AT/ET < 0.4 pattern can effectively predict massive and submassive pulmonary embolism. Doppler echocardiography may be a suitable noninvasive method for the diagnosis of pulmonary embolism.
HEALTH SCIENCE REPORTS
(2023)
Review
Pharmacology & Pharmacy
Shahnam Shamsabadi, Yazdan Nazer, Javad Ghasemi, Erfan Mahzoon, Vafa Baradaran Rahimi, Basiru O. Ajiboye, Vahid Reza Askari
Summary: In this study, the therapeutic and protective properties of zingerone were assessed against various chemical and natural toxins. Zingerone showed anti-inflammatory, antioxidant, and anti-apoptotic properties, and provided protection against radiation, chemicals, biological toxins, and oxidative stress. It also exhibited strong radioprotective properties. The authors hope that this review will inspire researchers to conduct further studies on the pharmaceutical applications and efficiency of zingerone in cancer treatment and drug adverse effects.
Article
Neurosciences
Vahid Reza Askari, Vafa Baradaran Rahimi, Reza Shafiee-Nick
Summary: This study investigated the protective effect of low doses of beta-Caryophyllene (BCP) on experimental autoimmune encephalomyelitis (EAE) mice, a chronic model of multiple sclerosis (MS). The results showed that BCP can reduce inflammation and improve pathological and clinical defects in EAE mice by modulating the immune system. BCP also increased the levels of anti-inflammatory cytokine IL-10 and decreased blood inflammatory cytokines. Therefore, low doses of BCP may be suggested as a therapeutic approach for MS with potent anti-inflammatory effects and possibly lower toxicity.
Article
Chemistry, Medicinal
Fahimeh Nourbakhsh, Seyed Hadi Mousavi, Pouria Rahmanian-Devin, Vafa Baradaran Rahimi, Hassan Rakhshandeh, Vahid Reza Askari
Summary: This study found that noscapine can significantly alleviate the inflammation symptoms of psoriasis, and it has a significant dose-dependent effect.
AVICENNA JOURNAL OF PHYTOMEDICINE
(2023)
Review
Immunology
Seyyed Mohammad Matin Alavi-Dana, Yazdan Gholami, Mohammadreza Meghdadi, Mohammad Saleh Fadaei, Vahid Reza Askari
Summary: This review discusses the pathogenesis of COVID-19 infection and the role of MSCs in suppressing inflammation and cytokine storm. Additionally, it reviews clinical trials and systematic reviews on the safety and efficacy of MSC therapy in the treatment of COVID-19 infection.
INFLAMMOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Pouria Rahmanian-Devin, Vahid Reza Askari, Zahra Sanei-Far, Vafa Baradaran Rahimi, Hossein Kamali, Mahmoud Reza Jaafari, Shiva Golmohammadzadeh
Summary: This study developed solid lipid nanoparticles (SLN) encapsulated noscapine (NOS) for the treatment of psoriasis. The SLN-NOS 1% formulation showed good stability, controlled release, and demonstrated significant improvements in clinical parameters and inflammatory levels.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.