Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Anran Cai, Sylvie Remy, Virissa Lenters, Bianca Cox, Greet Schoeters, Adrian Covaci, Roel Vermeulen, Lutzen Portengen
Summary: Childhood exposure to endocrine-disrupting chemicals (EDCs) may affect metabolic outcomes. Our study found associations between certain chemicals and body mass index, abdominal obesity, total cholesterol, and triglycerides. Further investigation is needed for sex-specific effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Environmental Sciences
ZhiChao Dang, Maria Arena, Aude Kienzler
Summary: This study summarized and evaluated the effects of TDCs on fish thyroid sensitive endpoints, including thyroid hormones, gene expression, and other aspects. The findings suggest that changes in thyroid sensitive endpoints may be influenced by various factors, such as the balance of different processes and environmental factors.
ENVIRONMENTAL POLLUTION
(2021)
Article
Obstetrics & Gynecology
M. Istvan, R. Rahban, B. Dananche, A. Senn, E. Stettler, L. Multigner, S. Nef, R. Garlantezec
Summary: The study found an association between maternal occupational exposure to potential endocrine-disrupting chemicals and a decrease in semen quality of their sons. Further research is needed to confirm this link and to inform pregnant women of potential hazards to their child's fertility.
HUMAN REPRODUCTION
(2021)
Review
Environmental Sciences
ZhiChao Dang
Summary: Both AMA and LAGDA are used to detect thyroid-mediated modality and adversity based on morphological changes during thyroid hormone-dependent metamorphosis. The EU Guidance recommends their use for investigating the effects of thyroid hormone system disrupting chemicals. However, there is debate over the necessity of using LAGDA as a follow-up to positive AMA results. This study analyzes the similarities, differences, and sensitivity of these two assays in detecting TDCs.
ENVIRONMENTAL POLLUTION
(2022)
Review
Endocrinology & Metabolism
Wiwat Rodprasert, Jorma Toppari, Helena E. Virtanen
Summary: Endocrine disrupting chemicals, particularly antiandrogenic EDCs, may impact male reproductive health, especially when exposed during fetal development at the sensitive 'masculinization programming window'.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Immacolata Cristina Nettore, Fabiana Franchini, Giuseppe Palatucci, Paolo Emidio Macchia, Paola Ungaro
Summary: Research has shown a possible association between obesity and endocrine-disrupting chemicals, which can interfere with energy metabolism and adipose tissue structure regulation. Early exposure to these chemicals may induce epigenetic modifications, making individuals susceptible to obesity and other diseases.
Review
Endocrinology & Metabolism
Vasantha Padmanabhan, Wenhui Song, Muraly Puttabyatappa
Summary: Exposure to endocrine-disrupting chemicals (EDCs) in the environment can disrupt the maternal-fetal environment and lead to adverse pregnancy outcomes. Research focuses on the effects of EDCs, the role of environmental and lifestyle factors, related mechanisms, and future research directions.
Article
Environmental Sciences
Sherly Antony, Sham Antony, Sharrel Rebello, Sandhra George, Devika T. Biju, R. Reshmy, Aravind Madhavan, Parameswaran Binod, Ashok Pandey, Raveendran Sindhu, Mukesh Kumar Awasthi
Summary: Endocrine Disrupting Chemicals (EDCs) pose a serious threat to the health and future of humans and the ecosystem. This review provides an overview of various EDCs, their toxic effects, and both conventional and modern remediation methods. The use of sustainable approaches like bioremediation has shown positive impacts in controlling EDC pollution.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Viviana Ramirez, Yolanda Galvez-Ontiveros, Pablo Jose Gonzalez-Domenech, Miguel Angel Baca, Lourdes Rodrigo, Ana Rivas
Summary: The study aimed to review limited literature on the effects of postnatal exposure to EDC on child neurodevelopment and behavior. While some research suggests a relationship between postnatal EDC exposure and adverse neurobehavioral outcomes in children, the underlying mechanisms of action remain unclear.
ENVIRONMENTAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Yan Yan, Fengjun Guo, Kexin Liu, Rixin Ding, Yichao Wang
Summary: Endocrine-disrupting chemicals (EDCs) are naturally occurring or artificial substances released into the environment. Humans are exposed to EDCs through ingestion, inhalation, and skin contact, and they are found in everyday household items. EDCs have negative effects on health, including cancer, cardiovascular risk, and reproductive disorders, and the placenta is particularly sensitive to their impact. This review evaluates the effects of various EDCs on placental development and function, identifies knowledge gaps, and guides future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Leonardo Trasande, Robert M. Sargis
Summary: Rapidly advancing evidence indicates that synthetic chemicals in the environment contribute to disease and disability across the lifespan. Endocrine-disrupting chemicals (EDCs) have a substantial impact on chronic diseases in adulthood, especially metabolic, cardiovascular, and reproductive conditions. The mortality and economic costs of exposure to certain phthalates are significant. Low-income and minority populations are disproportionately affected by these exposures. Government action is necessary to limit hazardous exposures and screen new chemicals. Routine healthcare should include guidance to reduce EDC exposures.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Environmental Sciences
Hanane Omichessan, Vittorio Perduca, Silvia Polidoro, Marina Kvaskoff, Therese Truong, German Cano-Sancho, Jean-Philippe Antignac, Laura Baglietto, Francesca Romana Mancini, Gianluca Severi
Summary: This study found numerous alterations in DNA methylation related to exposure to BFRs. If these findings are replicated in independent studies, they provide insights into the biological and health effects of BFRs.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
V. L. Marlatt, S. Bayen, D. Castaneda-Cortes, G. Delbes, P. Grigorova, V. S. Langlois, C. J. Martyniuk, C. D. Metcalfe, L. Parent, A. Rwigemera, P. Thomson, G. Van der Kraak
Summary: This review summarizes the current knowledge of the impacts of EDCs on reproductive success in wildlife and humans, with a focus on retrospective assessment and laboratory-based experiments. The evidence suggests that anthropogenic chemicals negatively impact reproduction by altering endocrine system function, particularly in aquatic species. Similar effects are observed in mammalian wildlife and humans in epidemiological studies. Further research is needed on the implications of chemical exposures during development and the potential for long-term reproductive effects. Field-based observations and long-term population level studies are key to addressing knowledge gaps.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Arash Derakhshan, Huan Shu, Maarten A. C. Broeren, Andreas Kortenkamp, Christian H. Lindh, Barbara Demeneix, Robin P. Peeters, Carl-Gustaf Bornehag, Tim I. M. Korevaar
Summary: This study investigated the association between concentrations of endocrine disrupting chemicals (EDCs) in urine and blood during pregnancy and serum human chorionic gonadotropin (hCG) concentrations. The results showed that higher exposure to bisphenol A was associated with lower hCG concentrations, while higher triclosan exposure was associated with higher hCG concentrations. Higher exposure to certain phthalates and polychlorinated biphenyls (PCBs) was also associated with lower hCG concentrations. These findings suggest that EDC exposure may have negative effects on placental hCG production and secretion, warranting further experimental studies.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Elise M. Philips, Susana Santos, Eric A. P. Steegers, Alexandros G. Asimakopoulos, Kurunthachalam Kannan, Leonardo Trasande, Vincent W. V. Jaddoe
ENVIRONMENT INTERNATIONAL
(2020)
Article
Environmental Sciences
Charissa van Zwol-Janssens, Leonardo Trasande, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Elise M. Philips, Fernando Rivadeneira, Vincent W. V. Jaddoe, Susana Santos
ENVIRONMENTAL RESEARCH
(2020)
Article
Environmental Sciences
Yuyan Wang, Yinxiang Wu, Melanie H. Jacobson, Myeonggyun Lee, Peng Jin, Leonardo Trasande, Mengling Liu
ENVIRONMENTAL HEALTH
(2020)
Article
Environmental Sciences
Arash Derakhshan, Elise M. Philips, Akhgar Ghassabian, Susana Santos, Alexandros G. Asimakopoulos, Kurunthachalam Kannan, Andreas Kortenkamp, Vincent W. V. Jaddoe, Leonardo Trasande, Robin P. Peeters, Tim I. M. Korevaar
Summary: Exposure to bisphenols during pregnancy may interfere with maternal thyroid function and affect the thyroid system in offspring. There were associations between BPA and BPS concentrations with maternal thyroid function, with late pregnancy BPA exposure linked to higher TSH in female newborns and higher FT4 during childhood in males.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Carolina C. V. Silva, Vincent W. V. Jaddoe, Chalana M. Sol, Hanan El Marroun, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Leonardo Trasande, Susana Santos
Summary: The study found that higher levels of DNOP metabolites at 6 years old were associated with an increased risk of overweight and adverse cardiovascular profile at both 6 and 10 years. On the other hand, higher total bisphenols and bisphenol A concentrations were linked to a decrease in BMI from 6 to 10 years.
Article
Multidisciplinary Sciences
Anne L. Dunlop, Alicynne Glazier Essalmi, Lyndsay Alvalos, Carrie Breton, Carlos A. Camargo, Whitney J. Cowell, Dana Dabelea, Stephen R. Dager, Cristiane Duarte, Amy Elliott, Raina Fichorova, James Gern, Monique M. Hedderson, Elizabeth Hom Thepaksorn, Kathi Huddleston, Margaret R. Karagas, Ken Kleinman, Leslie Leve, Ximin Li, Yijun Li, Augusto Litonjua, Yunin LudenaRodriguez, Juliette C. Madan, Julio Mateus Nino, Cynthia McEvoy, Thomas G. O'Connor, Amy M. Padula, Nigel Paneth, Frederica Perera, Sheela Sathyanarayana, Rebecca J. Schmidt, Robert T. Schultz, Jessica Snowden, Joseph B. Stanford, Leonardo Trasande, Heather E. Volk, William Wheaton, Rosalind J. Wright, Monica McGrath
Summary: This study examined the impact of maternal education and neighborhood SES markers on gestational age at birth, finding that higher maternal education was associated with a decreased odds of preterm birth, while lower education levels were linked to an increased odds of early term birth. Variations in these associations were observed among different racial/ethnic groups and across different regions in the United States.
Article
Environmental Sciences
Hongxiu Liu, Anna Maria Campana, Yuyan Wang, Kurunthachalam Kannan, Mengling Liu, Hongkai Zhu, Shilpi Mehta-Lee, Sara G. Brubaker, Linda G. Kahn, Leonardo Trasande, Akhgar Ghassabian
Summary: The study found that pregnant women in NYC had lower levels of OP pesticide metabolites than pregnant populations in Europe, Asia, and other regions in the U.S. Lower pre-pregnancy body mass index, being Asian, employed, and single were associated with higher DAP metabolite concentrations, while fruit and grain intakes were associated with higher Sigma DM, Sigma DE, and Sigma DAP levels.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Chalana M. Sol, Charissa Van Zwol-Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Leonardo Trasande, Susana Santos
Summary: Higher maternal bisphenol S urine concentrations, especially in the first trimester, seem to be associated with larger fetal head circumference, higher weight, and a lower risk of being small size for gestational age at birth. Other bisphenols were not consistently associated with fetal growth outcomes.
ENVIRONMENTAL HEALTH
(2021)
Article
Endocrinology & Metabolism
Melanie H. Jacobson, Cheryl R. Stein, Mengling Liu, Marra G. Ackerman, Jennifer K. Blakemore, Sara E. Long, Graziano Pinna, Raquel Romay-Tallon, Kurunthachalam Kannan, Hongkai Zhu, Leonardo Trasande
Summary: The study investigated the associations between urinary bisphenols and phthalates in early and midpregnancy with serum hormone concentrations and postpartum depression symptoms. The results suggested that certain phthalates were related to lower progesterone levels and increased odds of PPD, indicating a potential influence of endocrine disrupting chemicals on hormonal shifts during pregnancy and PPD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Environmental Sciences
Sara E. Long, Linda G. Kahn, Leonardo Trasande, Melanie H. Jacobson
Summary: This study investigated the association between phthalate metabolites and sex hormone concentrations in women, finding that DEHP was associated with lower estradiol and bioavailable testosterone concentrations in postmenopausal women, while DINCH was associated with higher free testosterone, bioavailable testosterone, and free androgen index. DEHTP was associated with a higher testosterone-to-estradiol ratio. Further research is needed to explore the safety of these chemicals.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Nutrition & Dietetics
Andrea L. Deierlein, Akhgar Ghassabian, Linda G. Kahn, Yelena Afanasyeva, Shilpi S. Mehta-Lee, Sara G. Brubaker, Leonardo Trasande
Summary: The study assessed the diet quality of pregnant women before and during pregnancy and found that Hispanic women had higher total HEI-2015 scores compared to non-Hispanic White women. Factors such as younger age, higher parity, single status, pre-pregnancy obesity, smoking, and other health behaviors were associated with lower total HEI-2015 scores. This highlights the need for continued nutritional counseling for preconception and prenatal care.
FRONTIERS IN NUTRITION
(2021)
Article
Environmental Sciences
Susana Santos, Chalana M. Sol, Charissa Van Zwol-Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Leonardo Trasande
Summary: Exposure to phthalates during pregnancy may lead to fetal growth restriction and preterm birth. Different trimester-specific exposures to phthalates may have varying effects on fetal growth and birth outcomes.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Melanie H. Jacobson, Yinxiang Wu, Mengling Liu, Kurunthachalam Kannan, Adela Jing Li, Morgan Robinson, Bradley A. Warady, Susan Furth, Howard Trachtman, Leonardo Trasande
Summary: The study found that urinary DAP metabolites were positively associated with renal injury biomarkers KIM-1 and 8-OHdG, as well as eGFR in children with CKD. These findings provide preliminary evidence that DAP metabolites in urine are related to subclinical kidney injury in children with CKD, which may indicate future clinical events.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Leonardo Trasande, Buyun Liu, Wei Bao
Summary: The study found that high-molecular weight phthalate metabolites, especially DEHP, were associated with increased mortality. Extrapolating to the 55-64 year old American population, the estimated attributable deaths related to phthalate exposure exceeded 90,000, with lost economic productivity in the billions of dollars.
ENVIRONMENTAL POLLUTION
(2022)
Article
Pediatrics
Sheryl L. Rifas-Shiman, L. Charles Bailey, Doug Lunsford, Matthew F. Daley, Ihuoma Eneli, Jonathan Finkelstein, William Heerman, Casie E. Horgan, Daniel S. Hsia, Melanie Jay, Goutham Rao, Juliane S. Reynolds, Jessica L. Sturtevant, Sengwee Toh, Leonardo Trasande, Jessica Young, Debby Lin, Christopher B. Forrest, Jason P. Block
Summary: The study found that antibiotic use before 24 months of age was associated with slightly higher BMI-z at 10 years old, but did not have a significant impact on the likelihood of overweight or obesity.
ACADEMIC PEDIATRICS
(2021)