期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 165, 期 -, 页码 9-13出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2017.12.006
关键词
Marble-burying behavior; Trifluoperazine; Obsessive-compulsive disorder
Trifluoperazine, a typical antipsychotic drug, not only antagonizes dopamine D-2 receptors but also enhances serotonin 5-HT2 receptor-mediated behavior. Moreover, trifluoperazine suppresses human purinergic receptor P2X7 responses and calmodulin. However, the effect of trifluoperazine on marble-burying behavior, which has been considered an animal model of obsessive compulsive disorder (OCD), has not been studied. Here, we examined the effect of trifluoperazine on marble-burying behavior in mice. Oral administration of paroxetine, a selective serotonin reuptake inhibitor, significantly reduced marble-burying behavior without affecting total locomotor activity. Similar results were obtained for trifluoperazine (3 mg/kg). The D-2 receptor agonist, quinpirole (0.03 mg/kg, intraperitoneal [i.p.]), and 5-HT2A receptor antagonist, ketanserin (0.3 mg/kg, i.p.), significantly counteracted this reduction of marble-burying behavior by trifluoperazine. These results show that trifluoperazine reduces marble-burying behavior via D-2 and 5-HT2A receptors, and may be a useful drug for the treatment of OCD.
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