Article
Environmental Sciences
Li-Ping Tao, Xue Li, Ming-Zhu Zhao, Jing-Ru Shi, Si-Qi Ji, Wen-Yuan Jiang, Qiu-Ju Liang, Yu-Hang Lei, Yi-Yao Zhou, Rong Cheng, Zhe Shi, Wenhai Deng, Jiayin Zhu, Shu-Yun Zhang
Summary: Polycyclic aromatic hydrocarbons (PAHs), particularly chrysene, have toxic effects on the liver by increasing relative liver weight and elevated serum ALT levels; the hepatotoxicity of chrysene is dependent on the aryl hydrocarbon receptor (AhR), while Nrf2 plays a crucial role in protecting against oxidative liver injury induced by chrysene.
Article
Environmental Sciences
Katsutoshi Ito, Takeshi Hano, Mana Ito, Toshimitsu Onduka, Nobuyuki Ohkubo, Kazuhiko Mochida
Summary: This study focuses on bioremediation using marine benthic animals and finds that Thalassodrilides cf. briani can decompose polycyclic aromatic hydrocarbons in contaminated sediments. Transcriptomic and metabolomic analyses reveal that the organism adapts to the polluted environment by regulating its metabolism.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Immunology
Xiaoyu Xi, Qinbin Ye, Danping Fan, Xiaoxue Cao, Qiong Wang, Xing Wang, Mengxiao Zhang, Yuan Xu, Cheng Xiao
Summary: Several factors, including genetic, epigenetic, and environmental factors, play important roles in the pathogenesis of rheumatoid arthritis (RA), with polycyclic aromatic hydrocarbons (PAHs) being a recently highlighted environmental factor. This review summarizes the recent progress in understanding the mechanisms of PAHs and aryl hydrocarbon receptors (AHRs) in RA, and discusses the development of therapeutic drugs targeting AHRs. Challenges and prospects of AHR application in the future are also discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lisa Goedtke, Heike Sprenger, Ute Hofmann, Felix F. Schmidt, Helen S. Hammer, Ulrich M. Zanger, Oliver Poetz, Albrecht Seidel, Albert Braeuning, Stefanie Hessel-Pras
Summary: PAHs are environmental pollutants generated by incomplete combustion of organic matter, which can induce their own metabolism by activating AHR and CAR. Most PAHs activate AHR, while non-carcinogenic PAHs tend to activate CAR, leading to the expression of respective target genes. Additionally, an increased PAH ring number is associated with AHR activation and DNA double-strand breaks, while smaller PAHs activate CAR but do not cause DNA damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Thiloka Kariyawasam, Gregory S. Doran, Julia A. Howitt, Paul D. Prenzler
Summary: PAHs are harmful pollutants in the environment. Extraction and quantification are important steps to understand contamination and implement remediation. Traditional extraction methods have limitations and newer, more environmentally friendly methods are being explored.
Article
Pharmacology & Pharmacy
Kuo-Liang Wei, Guan-Lun Gao, Yu-Ting Chou, Chih-Yi Lin, Shan-Chun Chen, Yi-Ling Chen, Hui Qin Choi, Chi-Chia Cheng, Jyan-Gwo Joseph Su
Summary: This study demonstrates that sorafenib is a potent AhR antagonist, which can effectively suppress the growth of hepatocellular carcinoma and other cancers.
Article
Chemistry, Multidisciplinary
Erik B. Schiferle, Wenxu Ge, Bjorn M. Reinhard
Summary: Despite recycling efforts, plastic waste continues to accumulate in the oceans, leading to the production of micro-and nanoscale plastic particles that can transport carcinogens. The fate and potential threats associated with plastics are still largely unknown.
Review
Environmental Sciences
Durgesh Nandini Das, Nathan Ravi
Summary: The presence of polycyclic aromatic hydrocarbons (PAHs) in the air has become a global concern due to their ability to cause cancer and alter genetic material. Exposure to environmental chemicals can lead to epigenetic changes, and PAHs, in particular benzo[a]pyrene (B[a]P), have been classified as cancer-causing agents. Epigenetic alterations play a significant role in PAH-induced carcinogenesis, leading to changes in DNA adduct formation. Increasing evidence suggests that exposure to PAHs can lead to various diseases and increase susceptibility. Further research is needed to understand the mechanisms of epigenetic changes and identify potential targets and biomarkers for diseases caused by PAH exposure.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Zhichao Wang, Qianli Ma, Xuan Huang, Tian Zhang, Jiawei Shao, Xinglin Zhang, Qian Shen, Xiaochen Wang, Jinjun Shao
Summary: In this study, AnI-SQ and AnI-SeQ, two organic functional materials, were successfully designed and synthesized. Their properties were characterized by theoretical calculations and experiments. The potential application of these materials was demonstrated through the self-assembly of polymeric nanoparticles.
CHINESE CHEMICAL LETTERS
(2022)
Article
Environmental Sciences
Ulrika Eriksson, Ivan A. Titaley, Magnus Engwall, Maria Larsson
Summary: Tire granulates recovered from end-of-life tires contain a complex mixture of toxic polyaromatic compounds (PACs), which are only partially monitored. This study used chemical analysis and bioassays to determine PAC concentrations and activities in tire granulates, revealing the presence of unknown bioactive compounds that contribute significantly to the effects observed. Further investigations are needed to identify and apportion these toxicants.
Article
Environmental Sciences
Inna A. Nemirovskaya, Peter O. Zavialov, Anastasia V. Khramtsova
Summary: The study investigates the content and composition of aliphatic hydrocarbons and polycyclic aromatic hydrocarbons in the suspended particulate matter and surface layer of bottom sediments in the Kerch Strait. The findings indicate higher concentrations of aliphatic hydrocarbons in the western part of the strait and lower concentrations of polycyclic aromatic hydrocarbons in the surface sediments. The study also highlights the increase in hydrocarbon content in water and sediments due to pollutant entry into the marine environment.
MARINE POLLUTION BULLETIN
(2022)
Article
Engineering, Environmental
Philip Tanabe, Daniela M. Pampanin, Hiwot M. Tiruye, Kare B. Jorgensen, Rachel I. Hammond, Rama S. Gadepalli, John M. Rimoldi, Daniel Schlenk
Summary: Previous studies have shown that 2-hydroxychrysene (2-OHCHR) is more toxic than 6-hydroxychrysene (6-OHCHR), reflecting regioselective toxicity. Our hypothesis is that differences in metabolism may contribute to the regioselective toxicity. Our experiments on Japanese medaka embryos indicate that CYP-mediated activation, potentially to 1,2-CAT, may explain the developmental toxicity differences of 2-OHCHR.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Nan Sun, Shijie Yu, Zhenxing Cai, Jin Liu, Tianyi Wang, Bowei Qi, Zijian Wang, Siming Wang, Anpei Yang, Guanglei Zhu, Weichen Gao, Ying Zhang
Summary: This study investigated the contamination of polycyclic aromatic hydrocarbons (PAHs) in sediments in rice and crab coculture farming systems. Rice straw biochar was used to inhibit the release and migration of PAHs from sediments, reducing the bioavailability and biological effects of PAHs. The results provide theoretical and technical support for the utilization of straw waste and remediation of PAHs pollution.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Environmental Sciences
Prarthana Shankar, Daniel L. Villeneuve
Summary: This study reveals that activation of aryl hydrocarbon receptors (Ahrs) can cause developmental toxicity and early-life stage mortality through two pathways: SOX9-mediated craniofacial malformations and cardiovascular toxicity. Evidence was collected and evaluated for the reliability of these adverse outcome pathways (AOPs), suggesting that they apply to most vertebrates and many Ahr-activating chemicals.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
David E. Couch, Angie J. Zhang, Craig A. Taatjes, Nils Hansen
Summary: The study provides laboratory confirmation of radical-radical chain reactions of resonance-stabilized species in a controlled pyrolysis environment, which contribute to particle growth in flames, the interstellar medium, and industrial reactors under high temperature and low pressure conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)